Doctoral School of Medicine and Pharmacy, I.O.S.U.D., George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu MuresRomania
Doctoral School of Medicine and Pharmacy, I.O.S.U.D., George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu MuresRomania
Department of Infectious Disease, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu MuresRomania
This work is licensed under the Creative Commons Attribution 4.0 International License.
Dhar SK, K V, Damodar S, Gujar S, Das M. IL-6 and IL-10 as predictors of disease severity in COVID-19 patients: results from meta-analysis and regression. Heliyon. 2021;7(2):e06155.DharSKKVDamodarSGujarSDasMIL-6 and IL-10 as predictors of disease severity in COVID-19 patients: results from meta-analysis and regressionHeliyon202172e06155Search in Google Scholar
Worldometer. Coronavirus statistics. Available from: https://www.worldometers.info/coronavirus/ [Accessed 31 August 2022]WorldometerCoronavirus statisticsAvailable from: https://www.worldometers.info/coronavirus/ [Accessed 31 August 2022]Search in Google Scholar
Sabaka P, Koščálová A, Straka I, et al. Role of interleukin 6 as a predictive factor for a severe course of Covid-19: retrospective data analysis of patients from a long-term care facility during Covid-19 outbreak. BMC Infect Dis. 2021;21(1):308.SabakaPKoščálováAStrakaIRole of interleukin 6 as a predictive factor for a severe course of Covid-19: retrospective data analysis of patients from a long-term care facility during Covid-19 outbreakBMC Infect Dis2021211308Search in Google Scholar
Santa Cruz A, Mendes-Frias A, Oliveira AI, et al. Interleukin-6 Is a Biomarker for the Development of Fatal Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia. Front Immunol. 2021;12.613422.Santa CruzAMendes-FriasAOliveiraAIInterleukin-6 Is a Biomarker for the Development of Fatal Severe Acute Respiratory Syndrome Coronavirus 2 PneumoniaFront Immunol202112613422Search in Google Scholar
Oi Y, Ogawa F, Yamashiro T, et al. Prediction of prognosis in patients with severe COVID-19 pneumonia using CT score by emergency physicians: a single-center retrospective study. Sci Rep. 2023;13(1):4045.OiYOgawaFYamashiroTPrediction of prognosis in patients with severe COVID-19 pneumonia using CT score by emergency physicians: a single-center retrospective studySci Rep20231314045Search in Google Scholar
Pons MJ, Ymaña B, Mayanga-Herrera A, Sáenz Y, Alvarez-Erviti L, Tapia-Rojas S, et al. Cytokine Profiles Associated With Worse Prognosis in a Hospitalized Peruvian COVID-19 Cohort. Front Immunol. 2021;12:700921.PonsMJYmañaBMayanga-HerreraASáenzYAlvarez-ErvitiLTapia-RojasSCytokine Profiles Associated With Worse Prognosis in a Hospitalized Peruvian COVID-19 CohortFront Immunol202112700921Search in Google Scholar
Lu L, Zhang H, Dauphars DJ, He YW. A Potential Role of Interleukin 10 in COVID-19 Pathogenesis. Trends in Immunology. 2021;42:3–5.LuLZhangHDaupharsDJHeYWA Potential Role of Interleukin 10 in COVID-19 PathogenesisTrends in Immunology20214235Search in Google Scholar
Montazersaheb S, Hosseiniyan Khatibi SM, Hejazi MS, et al. COVID-19 infection: an overview on cytokine storm and related interventions. Virol J. 2022;19(1):92.MontazersahebSHosseiniyan KhatibiSMHejaziMSCOVID-19 infection: an overview on cytokine storm and related interventionsVirol J202219192Search in Google Scholar
Basheer M, Saad E, Assy N. The Cytokine Storm in COVID-19: The Strongest Link to Morbidity and Mortality in the Current Epidemic. COVID. 2022;2(5):540–52.BasheerMSaadEAssyNThe Cytokine Storm in COVID-19: The Strongest Link to Morbidity and Mortality in the Current EpidemicCOVID20222554052Search in Google Scholar
Bonnet B, Cosme J, Dupuis C, et al. Severe COVID-19 is characterized by the co-occurrence of moderate cytokine inflammation and severe monocyte dysregulation. EBioMedicine. 2021;73:103622.BonnetBCosmeJDupuisCSevere COVID-19 is characterized by the co-occurrence of moderate cytokine inflammation and severe monocyte dysregulationEBioMedicine202173103622Search in Google Scholar
Kuri-Cervantes L, Pampena MB, Meng W, et al. Comprehensive mapping of immune perturbations associated with severe COVID-19. Sci Immunol. 2020;5(49).eabd7114.Kuri-CervantesLPampenaMBMengWComprehensive mapping of immune perturbations associated with severe COVID-19Sci Immunol2020549eabd7114Search in Google Scholar
Schulte-Schrepping J, Reusch N, Paclik D, et al. Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment. Cell. 2020;182(6):1419–40.Schulte-SchreppingJReuschNPaclikDSevere COVID-19 Is Marked by a Dysregulated Myeloid Cell CompartmentCell20201826141940Search in Google Scholar
Li J, Rong L, Cui R, et al. Dynamic changes in serum IL-6, IL-8, and IL-10 predict the outcome of ICU patients with severe COVID-19. Ann Palliat Med. 2021;10(4):3706–14.LiJRongLCuiRDynamic changes in serum IL-6, IL-8, and IL-10 predict the outcome of ICU patients with severe COVID-19Ann Palliat Med2021104370614Search in Google Scholar
Pons MJ, Ymaña B, Mayanga-Herrera A, et al. Cytokine Profiles Associated With Worse Prognosis in a Hospitalized Peruvian COVID-19 Cohort. Front Immunol. 2021;12:700921.PonsMJYmañaBMayanga-HerreraACytokine Profiles Associated With Worse Prognosis in a Hospitalized Peruvian COVID-19 CohortFront Immunol202112700921Search in Google Scholar
del Valle-Mendoza J, Tarazona-Castro Y, Merino-Luna A, et al. Comparison of cytokines levels among COVID-19 patients living at sea level and high altitude. BMC Infect Dis. 2022;22:96.del Valle-MendozaJTarazona-CastroYMerino-LunaAComparison of cytokines levels among COVID-19 patients living at sea level and high altitudeBMC Infect Dis20222296Search in Google Scholar
Ramasamy S, Subbian S. Critical Determinants of Cytokine Storm and Type I Interferon Response in COVID-19 Pathogenesis. Clin Microbiol Rev. 2021;34(3):e00299–20.RamasamySSubbianSCritical Determinants of Cytokine Storm and Type I Interferon Response in COVID-19 PathogenesisClin Microbiol Rev2021343e0029920Search in Google Scholar
Shekhawat J, Gauba K, Gupta S, et al. Interleukin-6 Perpetrator of the COVID-19 Cytokine Storm. Indian J Clin Biochem. 2021;36(4):440–50.ShekhawatJGaubaKGuptaSInterleukin-6 Perpetrator of the COVID-19 Cytokine StormIndian J Clin Biochem202136444050Search in Google Scholar
Mazaheri T, Ranasinghe R, Al-Hasani W, et al. A cytokine panel and procalcitonin in COVID-19, a comparison between intensive care and non-intensive care patients. PLoS One. 2022;17(5):e0266652.MazaheriTRanasingheRAl-HasaniWA cytokine panel and procalcitonin in COVID-19, a comparison between intensive care and non-intensive care patientsPLoS One2022175e0266652Search in Google Scholar
Lampart M, Zellweger N, Bassetti S, et al. Clinical utility of inflammatory biomarkers in COVID-19 in direct comparison to other respiratory infections—A prospective cohort study. PLoS One. 2022;17(5):e0269005.LampartMZellwegerNBassettiSClinical utility of inflammatory biomarkers in COVID-19 in direct comparison to other respiratory infections—A prospective cohort studyPLoS One2022175e0269005Search in Google Scholar
Rahayu R, Winarto W, Nasihun T. Interleukin-6 and C-reactive Protein on Admission as Predictor of Mortality in Severe COVID-19 Patients: A Retrospective Cohort Study. Open Access Maced J Med Sci. 2022;10(B):227–31.RahayuRWinartoWNasihunTInterleukin-6 and C-reactive Protein on Admission as Predictor of Mortality in Severe COVID-19 Patients: A Retrospective Cohort StudyOpen Access Maced J Med Sci202210B22731Search in Google Scholar
Brennan K, Zheng J. Interleukin 8. In Enna SJ, Bylund DB (eds): xPharm: The Comprehensive Pharmacology Reference. Amsterdam: Elsevier. 2007, p. 1–4.BrennanKZhengJInterleukin 8InEnnaSJBylundDB(eds):xPharm: The Comprehensive Pharmacology ReferenceAmsterdamElsevier200714Search in Google Scholar
Li L, Li J, Gao M, et al. Interleukin-8 as a Biomarker for Disease Prognosis of Coronavirus Disease-2019 Patients. Front Immunol. 2021;11:602395.LiLLiJGaoMInterleukin-8 as a Biomarker for Disease Prognosis of Coronavirus Disease-2019 PatientsFront Immunol202111602395Search in Google Scholar
Cesta MC, Zippoli M, Marsiglia C, et al. The Role of Interleukin-8 in Lung Inflammation and Injury: Implications for the Management of COVID-19 and Hyperinflammatory Acute Respiratory Distress Syndrome. Front Pharmacol. 2022;12:808797.CestaMCZippoliMMarsigliaCThe Role of Interleukin-8 in Lung Inflammation and Injury: Implications for the Management of COVID-19 and Hyperinflammatory Acute Respiratory Distress SyndromeFront Pharmacol202212808797Search in Google Scholar
Barnes BJ, Adrover JM, Baxter-Stoltzfus A, et al. Targeting potential drivers of COVID-19: Neutrophil extracellular traps. J Exp Med. 2020;217(6):e20200652.BarnesBJAdroverJMBaxter-StoltzfusATargeting potential drivers of COVID-19: Neutrophil extracellular trapsJ Exp Med20202176e20200652Search in Google Scholar
Islam H, Chamberlain TC, Mui AL, Little JP. Elevated Interleukin-10 Levels in COVID-19: Potentiation of Pro-Inflammatory Responses or Impaired Anti-Inflammatory Action? Front Immunol. 2021;12:677008.IslamHChamberlainTCMuiALLittleJPElevated Interleukin-10 Levels in COVID-19: Potentiation of Pro-Inflammatory Responses or Impaired Anti-Inflammatory Action?Front Immunol202112677008Search in Google Scholar
Diao B, Wang C, Tan Y, et al. Reduction and Functional Exhaustion of T Cells in Patients with Coronavirus Disease 2019 (COVID-19). Front Immunol. 2020;11:827.DiaoBWangCTanYReduction and Functional Exhaustion of T Cells in Patients with Coronavirus Disease 2019 (COVID-19)Front Immunol202011827Search in Google Scholar
Hasanvand A. COVID-19 and the role of cytokines in this disease. Inflammopharmacology. 2022;30(3):789–98.HasanvandACOVID-19 and the role of cytokines in this diseaseInflammopharmacology202230378998Search in Google Scholar
Han H, Ma Q, Li C, et al. Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors. Emerg Microbes Infect. 2020;9(1):1123–30.HanHMaQLiCProfiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictorsEmerg Microbes Infect202091112330Search in Google Scholar
Nagant C, Ponthieux F, Smet J, et al. A score combining early detection of cytokines accurately predicts COVID-19 severity and intensive care unit transfer. Int J Infect Dis. 2020;101:342–5.NagantCPonthieuxFSmetJA score combining early detection of cytokines accurately predicts COVID-19 severity and intensive care unit transferInt J Infect Dis20201013425Search in Google Scholar
Gotluru C, Roach A, Cherry SH, Runowicz CD. Sex, Hormones, Immune Functions, and Susceptibility to Coronavirus Disease 2019 (COVID-19)-Related Morbidity. Obstet Gynecol. 2021;137(3):423–9.GotluruCRoachACherrySHRunowiczCDSex, Hormones, Immune Functions, and Susceptibility to Coronavirus Disease 2019 (COVID-19)-Related MorbidityObstet Gynecol202113734239Search in Google Scholar
Bigdelou B, Sepand MR, Najafikhoshnoo S, et al. COVID-19 and Preexisting Comorbidities: Risks, Synergies, and Clinical Outcomes. Front Immunol. 2022;13:890517.BigdelouBSepandMRNajafikhoshnooSCOVID-19 and Preexisting Comorbidities: Risks, Synergies, and Clinical OutcomesFront Immunol202213890517Search in Google Scholar
Qin L, Li X, Shi J, et al. Gendered effects on inflammation reaction and outcome of COVID-19 patients in Wuhan. J Med Virol. 2020;92(11):2684–92.QinLLiXShiJGendered effects on inflammation reaction and outcome of COVID-19 patients in WuhanJ Med Virol20209211268492Search in Google Scholar
Queiroz MAF, Neves PFM das, Lima SS, et al. Cytokine Profiles Associated With Acute COVID-19 and Long COVID-19 Syndrome. Front Cell Infect Microbiol. 2022;12:922422.QueirozMAFNevesPFM dasLimaSSCytokine Profiles Associated With Acute COVID-19 and Long COVID-19 SyndromeFront Cell Infect Microbiol202212922422Search in Google Scholar
Bajaj V, Gadi N, Spihlman AP, Wu SC, Choi CH, Moulton VR. Aging, Immunity, and COVID-19: How Age Influences the Host Immune Response to Coronavirus Infections? Front Physiol. 2021;11:571416.BajajVGadiNSpihlmanAPWuSCChoiCHMoultonVRAging, Immunity, and COVID-19: How Age Influences the Host Immune Response to Coronavirus Infections?Front Physiol202111571416Search in Google Scholar
Dhurandhar NV, Bailey D, Thomas D. Interaction of obesity and infections. Obesity Reviews. 2015;16(12):1017–29.DhurandharNVBaileyDThomasDInteraction of obesity and infectionsObesity Reviews20151612101729Search in Google Scholar
Kim J, Bajaj M. Normal Adipose Tissue Biology: Adipocytokines and Inflammation. In McManus LM, Mitchell R (eds): Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms. Amsterdam: Elsevier. 2014, p. 488–97.KimJBajajMNormal Adipose Tissue Biology: Adipocytokines and InflammationInMcManusLMMitchellR(eds):Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease MechanismsAmsterdamElsevier201448897Search in Google Scholar
Guo J, Wang S, Xia H, et al. Cytokine Signature Associated With Disease Severity in COVID-19. Front Immunol. 2021;12:681516.GuoJWangSXiaHCytokine Signature Associated With Disease Severity in COVID-19Front Immunol202112681516Search in Google Scholar
Liu QQ, Cheng A, Wang Y, et al. Cytokines and their relationship with the severity and prognosis of coronavirus disease 2019 (COVID-19): a retrospective cohort study. BMJ Open. 2020;10(11):e041471.LiuQQChengAWangYCytokines and their relationship with the severity and prognosis of coronavirus disease 2019 (COVID-19): a retrospective cohort studyBMJ Open20201011e041471Search in Google Scholar
Hadjadj J, Yatim N, Barnabei L, et al. Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients. Science. 2020;369(6504):718–24.HadjadjJYatimNBarnabeiLImpaired type I interferon activity and inflammatory responses in severe COVID-19 patientsScience2020369650471824Search in Google Scholar
Ragab D, Salah Eldin H, Taeimah M, Khattab R, Salem R. The COVID-19 Cytokine Storm; What We Know So Far. Front Immunol. 2020;11:1446.RagabDSalah EldinHTaeimahMKhattabRSalemRThe COVID-19 Cytokine Storm; What We Know So FarFront Immunol2020111446Search in Google Scholar
Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020;395(10229):1033–4.MehtaPMcAuleyDFBrownMSanchezETattersallRSMansonJJCOVID-19: consider cytokine storm syndromes and immunosuppressionLancet20203951022910334Search in Google Scholar
Cifaldi L, Prencipe G, Caiello I, et al. Inhibition of natural killer cell cytotoxicity by interleukin-6: Implications for the pathogenesis of macrophage activation syndrome. Arthritis Rheumatol. 2015;67(11):3037–46.CifaldiLPrencipeGCaielloIInhibition of natural killer cell cytotoxicity by interleukin-6: Implications for the pathogenesis of macrophage activation syndromeArthritis Rheumatol20156711303746Search in Google Scholar
Isabel García-Laorden M, Lorente JA, Flores C, Slutsky AS, Villar J. Biomarkers for the acute respiratory distress syndrome: how to make the diagnosis more precise. Ann Transl Med. 2017;5(14):283.Isabel García-LaordenMLorenteJAFloresCSlutskyASVillarJBiomarkers for the acute respiratory distress syndrome: how to make the diagnosis more preciseAnn Transl Med2017514283Search in Google Scholar
Li H, Liu L, Zhang D, et al. SARS-CoV-2 and viral sepsis: observations and hypotheses. Lancet. 2020;395(10235):1517–20.LiHLiuLZhangDSARS-CoV-2 and viral sepsis: observations and hypothesesLancet202039510235151720Search in Google Scholar
Zhou J, He W, Liang J, et al. Association of Interleukin-6 Levels with Morbidity and Mortality in Patients with Coronavirus Disease 2019 (COVID-19). Jpn J Infect Dis 2021;74(4):293–8.ZhouJHeWLiangJAssociation of Interleukin-6 Levels with Morbidity and Mortality in Patients with Coronavirus Disease 2019 (COVID-19)Jpn J Infect Dis20217442938Search in Google Scholar