Yingjuan et al. (2007) | Ethanol concentrationExtracting timeExtracting powerRatio of liquid to propolis | Flavones | Response Surface Methodology (RSM) |
Wang et al. (2009) | Ethanol concentrationRatio of liquidThe holding time of pressurePressure to propolis | Flavones | RSM |
Kim et al. (2009) | Ethanol concentrationExtraction time | Total polyphenol content (TPC)Total flavonoid content (TFC) | RSM |
Li et al. (2012) | Microwave treatment timeMicrowave powerEthanol concentrationTemperatureTimeSolvent-to-solid | Total flavonoid yield | RSM |
Yuan et al. (2013) | Ratio of lipid to drugRatio of soybean phospholipid to cholesterolSpeed of injection | Propolis flavonoids liposome (PFL) | RSM |
Zhao et al. (2012) | Extraction timeEthanol concentrationSolid-liquid ratioDistilling frequencyDistilling temperature | Extraction ratio TFC | RSM |
Oldoni et al. (2015) | Ethanol ratioTemperature Time | TPCDPPH | 23 factorial design |
Nichitoi et al. (2019) | Particle sizeSolvent type (ethanolic aqueous)Extraction duration | TPCTFCAntioxidant capacity | Partial Least Squares Regression |
Our study | Ethanol contentExtraction time | TPC (Single objective)FRAP activities (Single objective)TPC and FRAP (Multi-objective) | ANN and MFO |