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Figure 1:
Structure of the HLA-E, -F, and -G genes.
Figure 2:
HLA-E expressed on a tumour cell, interacting with immune cells. Note: CD8+ = T cytotoxic cell; NK = natural killer cell.
Figure 3:
HLA-F expressed on a tumour cell, interacting with NK and T cell receptors. Note: NK = natural killer cell; KIR3DL2 = Killer cell Immunoglobulin Like Receptor; ILT-2, -4 = inhibitory receptors Ig-like transcripts.
Figure 4:
HLA-G expressed on a tumour cell, interacting with immune cell receptors. Note: CD8+ = T cytotoxic cell; CD4+ = T helper cell; Treg = T regulatory cell; NK = natural killer cell; DC = dendritic cell; Neu = neutrophil; ILT-2, -4 = inhibitory receptors Ig-like transcripts; KIR2DL4 = killer cell Ig-like receptor.