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Expression of the Non-classical HLA-E, -F, -G Molecules in the Tumour Microenvironment

Anastasia Ormandjieva

Anastasia Ormandjieva

Department of Clinical Immunology, Medical Faculty, Medical University — Sofia, University Hospital AlexandrovskaSofia, Bulgaria
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Ormandjieva, Anastasia
  
Aug 03, 2023
Expression of the Non-classical HLA-E, -F, -G Molecules in the Tumour Microenvironment's Cover Image
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Article Category: Research Article
Published Online: Aug 03, 2023
Page range: 53 - 62
Received: Sep 20, 2022
Accepted: Jan 09, 2023
DOI: https://doi.org/10.2478/fco-2022-0008
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© 2022 Anastasia Ormandjieva, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1:

Structure of the HLA-E, -F, and -G genes.
Structure of the HLA-E, -F, and -G genes.

Figure 2:

HLA-E expressed on a tumour cell, interacting with immune cells. Note: CD8+ = T cytotoxic cell; NK = natural killer cell.
HLA-E expressed on a tumour cell, interacting with immune cells. Note: CD8+ = T cytotoxic cell; NK = natural killer cell.

Figure 3:

HLA-F expressed on a tumour cell, interacting with NK and T cell receptors. Note: NK = natural killer cell; KIR3DL2 = Killer cell Immunoglobulin Like Receptor; ILT-2, -4 = inhibitory receptors Ig-like transcripts.
HLA-F expressed on a tumour cell, interacting with NK and T cell receptors. Note: NK = natural killer cell; KIR3DL2 = Killer cell Immunoglobulin Like Receptor; ILT-2, -4 = inhibitory receptors Ig-like transcripts.

Figure 4:

HLA-G expressed on a tumour cell, interacting with immune cell receptors. Note: CD8+ = T cytotoxic cell; CD4+ = T helper cell; Treg = T regulatory cell; NK = natural killer cell; DC = dendritic cell; Neu = neutrophil; ILT-2, -4 = inhibitory receptors Ig-like transcripts; KIR2DL4 = killer cell Ig-like receptor.
HLA-G expressed on a tumour cell, interacting with immune cell receptors. Note: CD8+ = T cytotoxic cell; CD4+ = T helper cell; Treg = T regulatory cell; NK = natural killer cell; DC = dendritic cell; Neu = neutrophil; ILT-2, -4 = inhibitory receptors Ig-like transcripts; KIR2DL4 = killer cell Ig-like receptor.

Alleles and proteins of HLA class I molecules[8]_

HLA-Ia molecules
Gene A B C E F G
Alleles 7,562 9,000 7,513 311 56 104
Proteins 4,399 5,414 4,157 121 11 35
Nulls 392 312 324 8 0 5
Language:
English
Publication timeframe:
2 times per year
Journal Subjects:
Medicine, Clinical Medicine, Internal Medicine, Haematology, Oncology
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