<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Background</h3><p>Sialic acids are alpha-keto acids with nine carbons that are commonly present in the terminal sugars of glycans on glycoproteins and glycolipids on the cell surface. Sialic acids have a role in a variety of physiological and pathological processes by interacting with carbohydrates and proteins, communicating between cells, and acting as cell surface receptors for viruses and bacteria. Several studies have shown the aberrant pattern of sialic acids on cancer cells due to change in their glycosylation status. This pattern may be attributed to various physiological and pathological changes occurring in tumour cells. Hypersialylation in tumours, its involvement in tumour growth, immune evasion and escape from the apoptotic pathway, metastasis formation, and therapeutic resistance have all been fairly well investigated.</p></sec>
<sec><h3>Methods</h3><p>A PubMed search was conducted and published articles in different studies from 2000 to 2020 were included and reviewed. Here, we discuss current outcomes that emphasize the unfavourable effects of hypersialylation on multiple aspects of tumour genesis, immune evasion, metastasis and resistance to therapy.</p></sec>
<sec><h3>Conclusion</h3><p>These recent investigations have found that aberrant sialylation is an essential process for tumour cells to evade immune surveillance and maintain their malignancy. Together, these noteworthy views provide a solid platform for designing and developing therapeutic approaches that target hypersialylation of cancer cells.</p></sec>
</abstract>

BackgroundSialic acids are alpha-keto acids with nine carbons that are commonly present in the terminal sugars of glycans on glycoproteins and glycolipids on the cell surface. Sialic acids have a role in a variety of physiological and pathological processes by interacting with carbohydrates and proteins, communicating between cells, and acting as cell surface receptors for viruses and bacteria. Several studies have shown the aberrant pattern of sialic acids on cancer cells due to change in their glycosylation status. This pattern may be attributed to various physiological and pathological changes occurring in tumour cells. Hypersialylation in tumours, its involvement in tumour growth, immune evasion and escape from the apoptotic pathway, metastasis formation, and therapeutic resistance have all been fairly well investigated.
MethodsA PubMed search was conducted and published articles in different studies from 2000 to 2020 were included and reviewed. Here, we discuss current outcomes that emphasize the unfavourable effects of hypersialylation on multiple aspects of tumour genesis, immune evasion, metastasis and resistance to therapy.
ConclusionThese recent investigations have found that aberrant sialylation is an essential process for tumour cells to evade immune surveillance and maintain their malignancy. Together, these noteworthy views provide a solid platform for designing and developing therapeutic approaches that target hypersialylation of cancer cells.

Sialic acids: An Avenue to Target Cancer Progression, Metastasis, and Resistance to Therapy

SDM Research Institute for Biomedical Sciences

A Constituent unit of Shri Dharmasthala Manjunatheshwara University

Department of Biotechnology, Basaveshwar Engineering College

Forum of Clinical Oncology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

BackgroundSialic acids are alpha-keto acids with nine carbons that are commonly present in the terminal sugars of glycans on glycoproteins and glycolipids on...

Sialic acids: An Avenue to Target Cancer Progression, Metastasis, and Resistance to Therapy

Article Category: Review

Publicado en línea: 19 abr 2022

Páginas: 40 - 48

Recibido: 09 jul 2021

Aceptado: 15 sept 2021

DOI: https://doi.org/10.2478/fco-2021-0006

Palabras clave
chemoresistance, immune evasion, metastasis, sialic acids, tumorigenesis

© 2021 Mallikarjun Goni et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1

Sialic acids: An Avenue to Target Cancer Progression, Metastasis, and Resistance to Therapy

Article Category: Review

Publicado en línea: 19 abr 2022

Páginas: 40 - 48

Recibido: 09 jul 2021

Aceptado: 15 sept 2021

DOI: https://doi.org/10.2478/fco-2021-0006

Palabras clavechemoresistance, immune evasion, metastasis, sialic acids, tumorigenesis

© 2021 Mallikarjun Goni et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1

Palabras clave
chemoresistance, immune evasion, metastasis, sialic acids, tumorigenesis