[1. Heymsfield SB, Gonzalez MC, Shen W, Redman L, Thomas D. Weight loss composition is one-fourth fat-free mass: a critical review and critique of this widely cited rule. Obes Rev. 2014;15:310-21.10.1111/obr.12143397020924447775]Search in Google Scholar
[2. Hall JE, da Silva AA, do Carmo JM, Dubinion J, Hamza S, Munusamy S, et al. Obesity-induced hypertension: role of sympathetic nervous system, leptin, and melanocortins. J Biol Chem. 2010;285: 17271-6.10.1074/jbc.R110.113175287848920348094]Search in Google Scholar
[3. Lаzаr M. Hоw obеsіty cаusеs dіаbеtеs: nоt а tаll tаlе. Scіеncе. 2005; 307:373-5.]Search in Google Scholar
[4. Shаrmа А. Оbеsіty аnd cаrdіоvаsculаr rіsk. Grоwth Hоrmоnе & ІGF Rеsеаrch. 2003;13:107.]Search in Google Scholar
[5. K. Wоlіn, K. Cаrsоn, G. Cоldіtz. Оbеsіty аnd Cаncеr. Thе Оncоlоgіst. 2009;6:556-65.]Search in Google Scholar
[6. Farag YMK, Gaballa MR. Diabesity: an overview of a rising epidemic. Nephrol Dial Transplant. 2011;26:28-35.10.1093/ndt/gfq57621045078]Search in Google Scholar
[7. Xіu-Huа Shеn, Qіng-Yа Tаng, Juаn Huаng, Wеі Cаі. Vіtаmіn Е rеgulаtеs аdіpоcytоkіnееxprеssіоn іn а rаt mоdеl оf dіеtаry-іnducеd оbеsіty. Еxp Bіоl Mеd. 2010;235:47-51.]Search in Google Scholar
[8. Grodsky GM. The importance of rapid insulin secretion: revisited. Diabetes Technol Ther. 1999;1:259-60.10.1089/15209159931716111475271]Search in Google Scholar
[9. Dedoussis GV, Kaliora AC, Panagiotakos DB. Genes, diet and type 2 diabetes mellitus: a review. Rev Diabet Stud. 2007;4:13-24.10.1900/RDS.2007.4.13189252317565412]Search in Google Scholar
[10. Ferrannini E, Camastra S, Gastaldelli A, Sironi MA, Natali A, Muscelli E, et al. Beta-cell function in obesity: effects of weight loss. Diabetes. 2004;53(Suppl 3):S26-S33.10.2337/diabetes.53.suppl_3.S2615561918]Search in Google Scholar
[11. Maddux BA, See W, Lawrence JC, Goldfine AL, Goldfine ID, Evans JL. Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by mircomolar concentrations of alpha-lipoic acid. Diabetes. 2001;50:404-10.10.2337/diabetes.50.2.40411272154]Search in Google Scholar
[12. Bashan N, Kovsan J, Kachko I, Ovadia H, Rudich A. Physiol Rev. 2009;89:27-71.]Search in Google Scholar
[13. Kern L, Mittenbühler MJ, Vesting AJ, Ostermann AL, Wunderlich CM, Wunderlich FT. Obesity-induced TNFα and IL-6 signaling: the missing link between obesity and inflammation – driven liver and colorectal cancers. Cancers (Basel). 2019;11(1):24.10.3390/cancers11010024635622630591653]Search in Google Scholar
[14. Bryan S, Baregzay B, Spicer D, Singal PK, Khaper N. Redox-inflammatory synergy in the metabolic syndrome. Can J Physiol Pharmacol. 2013;91:22-30.10.1139/cjpp-2012-029523368637]Search in Google Scholar
[15. Dobrian AD, Davies MJ, Prewitt RL, Lauterio TJ. Development of hypertension in a rat model of diet-induced obesity. Hypertension. 2000;35:1009-15.10.1161/01.HYP.35.4.100910775577]Search in Google Scholar
[16. Yin H, Xu L,Porter NA. Free radical lipid peroxidation: mechanisms and analysis. Chem Rev. 2011;10:5944-72.10.1021/cr200084z]Search in Google Scholar
[17. Ayala A, Muñoz MF, Argüelles S. Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-Hydroxy-2-Nonenal. Oxid Med Cell Longev. 2014;360438.10.1155/2014/360438]Search in Google Scholar
[18. Kumar A, Ilavarasan R, Jayachandran T, Decaraman M, Aravindan P, Padmanabhan N, et al. Anti-diabetic activity of Syzygium cumini and its isolated compound against streptozotocin-induced diabetic rats. J Med Plant Res. 2008;2:246-9.]Search in Google Scholar
[19. Bedekar A, Shah K, Koffas M, Allen IL, Sima S, Geoffrey MG. Chapter 2 natural products for type II diabetes treatment. Adv Appl Microbiol. 2010;71:21-73.10.1016/S0065-2164(10)71002-9]Search in Google Scholar
[20. Gandhi GR, Ignacimuthu S, Paulraj MG, Sasikumar P. Antihyperglycemic activity and antidiabetic effect of methyl caffeate isolated from Solanum torvum Swartz. Fruit in streptozotocin induced diabetic rats. Eur J Pharm. 2011;670:23-31.]Search in Google Scholar
[21. Gupta S, Sidhu MC, Ahluwalia AS. Plant-based remedies for the management of diabetes. Curr Botany. 2017;8:34-40.10.19071/cb.2017.v8.3169]Search in Google Scholar
[22. Vronskaya LV. Standardization of dry extract of bean pods on the content of flavonoids. Med Clin Chem. 2018;20(1):123-9. Article in Russian]Search in Google Scholar
[23. Lee ER, Kang YJ, Choi HY, Kang GH, Kim JH, Kim BW, et al. Induction of apoptotic cell death by synthetic naringenin derivatives in human lung epithelial carcinoma a549 cells. Biol Pharm Bull. 2007;30:2394-8.10.1248/bpb.30.2394]Search in Google Scholar
[24. Jayaprakasam B, Olson LK, Schutzki RE, Tai MH, Nair MG. Amelioration of obesity and glucose intolerance in high-fat-fed c57bl/6 mice by anthocyanins and ursolic acid in cornelian cherry (Cornus mas). J Agric Food Chem. 2006;54:243-8.10.1021/jf0520342]Search in Google Scholar
[25. Prasain J, Carlson S, Wyss J. Flavonoids and age-related disease: Risk, benefits and critical windows. Maturitas. 2010; 66:163-71.10.1016/j.maturitas.2010.01.010]Search in Google Scholar
[26. Lee ER, Kang GH, Cho SG. Effect of flavonoids on human health: Old subjects but new challenges. Recent Pat Biotechnol. 2007;1:139-50.10.2174/187220807780809445]Search in Google Scholar
[27. Chen CK, Pace-Asciak CR. Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta. General Pharmacol. 1996; 2:363-6.10.1016/0306-3623(95)02001-2]Search in Google Scholar
[28. Konopelnyuk VV, Karpovets TP, Ostapchenko LI. Rat serum amino acid content under conditions of obesity caused by separate and combined consumption of high-calorie diet and 10% fructose solution. Res J Phar Bio Chem Sci. 2015;6(3):457-64.]Search in Google Scholar
[29. Hubert JW, Feinleib M, McNamara PM. Obesity as an independent risk factor for cardiovascular disease: a 26-year followup of participant in the Framingham. Heart Study. Circulation. 1983;67: 968-77.10.1161/01.CIR.67.5.9686219830]Search in Google Scholar
[30. Braz J. Effect of an aqueous extract of Phaseolus vulgaris on the properties of tail tendon collagen of rats with streptozotocin-induced diabetes. Med Biol Res. 2003;36(7):861-70.10.1590/S0100-879X2003000700006]Search in Google Scholar
[31. Glycosylated hemoglobin. Pliva-Lachema Diagnostica. 2008; 10003258.]Search in Google Scholar
[32. Crowther JR. The ELISA Guidebook. New Jersey: Humana Press Inc; 2001;436.10.1385/1592590497]Search in Google Scholar
[33. Orekhovich VN. Modern methods in biochemistry. Medicine. 1977; 392. Article in Russian]Search in Google Scholar
[34. Halenova T, Raksha N, Vovk T, Savchuk O, Ostapchenko L, Prylutskyy Y, et al. Effect of C60 fullerene nanoparticles on the diet-induced obesity in rats. Int J Obes (Lond). 2018;42(12):1987-98.10.1038/s41366-018-0016-2]Search in Google Scholar
[35. Kostyuk VA. Spectrophotometric determination of diene conjugates. Quest Med Chem. 1984;4:125-7. Article in Russian10.1002/abio.370040207]Search in Google Scholar
[36. Halenova T, Savchuk O, Ostapchenko L, Chursov A, Fridlyand N, Komissarov AB, et al. P62 plasmid can alleviate diet-induced obesity and metabolic dysfunctions. Oncotarget. 2017;8(34):56030-40.10.18632/oncotarget.19840]Search in Google Scholar
[37. Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys. 1959;82(1):70-7.10.1016/0003-9861(59)90090-6]Search in Google Scholar
[38. Dubinina EE. Oxidative modification of human serum proteins, method for its determining. Quest Med Chem. 1995;1:24-6. Article in Russian]Search in Google Scholar
[39. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analyt Biochem. 1976;72:248-54.10.1016/0003-2697(76)90527-3]Search in Google Scholar
[40. Kyznetsova M, Halenova T, Dovgusha O, Savchuk O. Effect of an aqueous extract of Phaseolus vulgaris pods on blood glucose and body weight in diabetic rats. Probl Regul Physiol Functions. 2015; 1(18):52.]Search in Google Scholar
[41. Santimone M, Koukiekolo R, Moreau Y, Le Berre V, Rouge P, Marchis-Mouren G, et al. Porcine pancreatic alpha-amylase inhibition by the kidney bean (Phaseolus vulgaris) inhibitor (Alpha-AII) and structural changes in the alphaamylase inhibitor complex. Biochim Biophys Acta. 2004;1696:181-90.10.1016/j.bbapap.2003.11.00114871659]Search in Google Scholar
[42. Xiangming Wu, Xiaofeng Xu, Jianguo Shen, Nicholas VР. Enhanced weight loss from a dietary supplement containing standardized Phaseolus vulgaris extract in Overweight Men and Women. J App Res. 2010;10(2):73-9.]Search in Google Scholar
[43. Helmstädter AJ. Beans and diabetes: Phaseolus vulgaris preparations as antihyperglycemic agents. J Med Food. 2010;13(2):251-4.10.1089/jmf.2009.000220132042]Search in Google Scholar
[44. Pari L, Venkateswaran S. Effect of an aqueous extract of Phaseolus vulgaris on plasma insulin and hepatic key enzymes of glucose metabolism in experimental diabetes. Braz J Med Biol Res. 2003;36(7):861-870.10.1590/S0100-879X2003000700006]Search in Google Scholar
[45. Mudi SR, Akhter M, Biswas SK, Muttalib MA, Choudhury S, Rokeya B, et al. Effect of aqueous extract of Aegle marmelos fruit and leaf on glycemic, insulinemic and lipidemic status of type 2 diabetic model rats. J Complement Integrat Med. 2017;14(2):86-92.10.1515/jcim-2016-0111]Search in Google Scholar
[46. Rоbеrtsоn RP, Harmon J, Tаnаkа Y, Tran PO, Poitout V. Glucоsе tоxіcіty оf thе β-cеll: cеllulаr аnd mоlеculаr mеchаnіsms. Dіаbеtеs Mеllіtus. 2000;8:129-39.]Search in Google Scholar
[47. Bоdеn G. Rоlе оf fаtty аcіds іn thе pаthоgеnеsіs оf іnsulіn rеsіstаncе аnd NІDDM. Dіаbеtеs. 1997;46(3):3-10.]Search in Google Scholar
[48. Chakravarthy BK, Gupta S, Gode KD. Functional beta cell regeneration in the islets of pancreas in alloxan induced diabetic rats by (-)-epicatechin. Life Sci. 1982;31:2693-7.10.1016/0024-3205(82)90713-5]Search in Google Scholar
[49. Sabitha K, Venugopal B, Rafi MD, Ramana KV. Role of antioxidant enzymes in glucose and lipid metabolism in association with obesity and Type 2 Diabetes. Am J Med Sci Med. 2014;2(1):21-4.]Search in Google Scholar
[50. Dobrian AD, Davies MJ, Prewitt RL, Lauterio TJ. Development of hypertension in a rat model of dietinduced obesity. Hypertension. 2000;35:100915.10.1161/01.HYP.35.4.1009]Search in Google Scholar
[51. Reed TT. Lipid peroxidation and neurodegenerative disease. Free Radic Biol Med. 2011;51(7):1302-19.10.1016/j.freeradbiomed.2011.06.02721782935]Search in Google Scholar
[52. Vázquez-Torres A. Redox active thiol sensors of oxidative and nitrosative stress. Antioxid Redox Signal. 2012;17:1201-14.10.1089/ars.2012.4522343047922257022]Search in Google Scholar
[53. Yurchenko A, Krenytska D, Tymoshenko M. The rat blood glutathione system under obesity development with the compatible consumption of the kidney bean (Phaseolus vulgaris) pods extract. Visnyk Taras Shevchenko National University of Kyiv. 2018;76(2):37-42.10.17721/1728_2748.2018.76.37-42]Search in Google Scholar
[54. Hertog MG, Hollman PC. Potential health effects of the dietary flavonol quercetin. Eur J Clin Nutr. 1996;50:63-71.]Search in Google Scholar
[55. Zhang Y, Liu D. Flavonol kaempferol improves chronic hyperglycemia-impaired pancreatic beta-cell viability and insulin secretory function. Eur J Pharmacol. 2011;670:32532.10.1016/j.ejphar.2011.08.01121914439]Search in Google Scholar
[56. Byun MR, Jeong H, Bae SJ, Kim AR, Hwang ES, Hong JH. TAZ is required for the osteogenic and anti-adipogenic activities of kaempferol. Bone. 2011;50(1):364-72.10.1016/j.bone.2011.10.03522108137]Search in Google Scholar
[57. Zhang Z, Ding Y, Dai X, Wang J, Li Y. Epigallocatechin-3-gallate protects pro-inflammatory cytokine induced injuries in insulin-producing cells through the mitochondrial pathway. Eur J Pharmacol. 2011;670:311-6.10.1016/j.ejphar.2011.08.03321925162]Search in Google Scholar
[58. Román-Ramos R, Flores-Sáenz JL, Partida-Hernández G, Lara-Lemus A, Alarcón-Aguilar F. Experimental study of the hypoglycemic effect of some antidiabetic plants. Arch Invest Med (Mex). 1991;22(1):87-93.]Search in Google Scholar
[59. Kyznetsova M, Makieieva O, Lavrovska D, Tymoshenko M, Sheverova D, Halenova T, et al. Effect of Aqueous Extract from Phaseolus vulgaris Pods on Lipid Peroxidation and Antioxidant Enzymes Activity in the Liver and Kidney of Diabetic Rats. J Appl Pharm Scie. 2015;5(05):001-6.10.7324/JAPS.2015.50501]Search in Google Scholar