The Journal of Institute of Experimental Pharmacology of Slovak Academy of Sciences

Interdisciplinary Toxicology

Interd. Toxicology ONL

<abstract xml:lang="en"><title style='display:none'>Editorial</title>Modern society is constantly increasing the volume of chemicals for everyday use, including drugs, additives, food stabilizers, cosmetics or ubiquitous by-products of the industry. More than 65,000 chemicals are in the U.S. Environmental Protection Agency's inventory of toxic chemicals and annually the Agency receives approximately 1,500 notices of intent to manufacture new substances. It is thus important to know what each of this compound can do to the living organism. Thanks to developmental toxicology, it has become evident that even small amounts of potentially toxic compounds introduced to the developing organism may be the cause of later morbidity. This phenomenon is known as developmental origins of health and diseases (DOHaD). It is therefore very important to understand the potential risks. Toxicology is interdisciplinary science utilizing methods and knowledge from a number of scientific fields like biology, pharmacology, biochemistry, pathophysiology, genetics, etc. Understanding the adverse effects of compounds in the environment may influence our everyday decisions and might shift the course of our life toward happiness.One of the goals of the Slovak Toxicology Society SETOX, together with the Institute of Experimental Pharmacology &amp; Toxicology SASc., Bratislava, is to impart scientific knowledge and experience to the public, and especially to the young generation. This group has definitely the greatest potential to materialize positive changes in our environment and to promote the protection of our planet. Every experience matters, every encounter, knowledge, situation or person might change our perspective. Thus to pass on knowledge and to educate the young generation is a matter of utmost importance.</abstract>

Editorial

Institute of Experimental Pharmacology & Toxicology, Dúbravská cesta Bratislava, Slovakia

<article-title>Editorial</article-title>

{"article-title":"Editorial"}

<abstract xml:lang="en"><title style='display:none'>Protective effects of manganese(II) chloride on hyaluronan degradation by oxidative system ascorbate <italic>plus</italic> cupric chloride</title>The degradation of several high-molar-mass hyaluronan samples was investigated in the presence of ascorbic acid itself and further by an oxidative system composed of ascorbic acid plus transition metal ions, i.e. Fe(II) or Cu(II) ions. The latter oxidative system imitates conditions in a joint synovial fluid during early phase of acute joint inflammation and can be used as a model for monitoring oxidative degradation of hyaluronan under pathophysiological conditions. The system Cu(II) <italic>plus</italic> ascorbate (the Weissberger oxidative system) resulted in a more significant decrease of hyaluronan molar mass compared to the oxidative system Fe(II) plus ascorbate. Addition of manganese(II) chloride was found to decrease the rate of the oxidative damage of hyaluronan initiated by ascorbate itself and by the Weissberger system.</abstract>

Protective effects of manganese(II) chloride on hyaluronan degradation by oxidative system ascorbate  cupric chloride

Institute of Experimental Pharmacology & Toxicology, Slovak Academy of Sciences, SK-84104 Bratislava, Slovakia

Institute of Chemistry, Center for Glycomics, Slovak Academy of Sciences, SK-84538 Bratislava, Slovakia

Directorate Health, Directorate General Research, European Commission, B-1049, Brussels, Belgium

Keywords

<article-title>Protective effects of manganese(II) chloride on hyaluronan degradation by oxidative system ascorbate <italic>plus</italic> cupric chloride</article-title>

<abstract xml:lang="en"><title style='display:none'>Pharmacokinetics of cytisine after single intravenous and oral administration in rabbits</title>The aim of this study is to develop a sensitive HPLC method for the quantitative determination of cytisine in serum and to characterize the pharmacokinetic behaviour of cytisine after oral and intravenous administration in rabbits. The pharmacokinetic behaviour of cytisine is studied in male and female New Zealand rabbits after oral and intravenous administration. Cytisine is administered orally (dose of 5 mg/kg b.w.) under fasting condition (12 hours) and intravenously (dose 1 mg/kg b.w.) in the marginal ear vein. Cytisine serum concentrations are measured using a highly selective and sensitive validated HPLC method with UV detection. Linearity of the method is in the range 12-2 400 μg/L; accuracy and precision are both within ± 10%, and the limit of detection is 4 μg/L. Selectivity and stability are also validated. Basic pharmacokinetic parameters of cytisine after single oral and intravenous administration are calculated using TOPFIT software. Pharmacokinetic analysis suggests a rapid but incomplete absorption of cytisine after oral administration.</abstract>

Pharmacokinetics of cytisine after single intravenous and oral administration in rabbits

Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University, Sofia, Bulgaria

Central Laboratory of Therapeutic Drug Monitoring and Clinical Pharmacology, Faculty of Medicine, Alexander University Hospital, Medical University, Sofia, Bulgaria

<article-title>Pharmacokinetics of cytisine after single intravenous and oral administration in rabbits</article-title>

<abstract xml:lang="en"><title style='display:none'>Different experimental approaches in modelling cataractogenesis</title>Cataract, the opacification of eye lens, is the leading cause of blindness worldwide. At present, the only remedy is surgical removal of the cataractous lens and substitution with a lens made of synthetic polymers. However, besides significant costs of operation and possible complications, an artificial lens just does not have the overall optical qualities of a normal one. Hence it remains a significant public health problem, and biochemical solutions or pharmacological interventions that will maintain the transparency of the lens are highly required. Naturally, there is a persistent demand for suitable biological models. The ocular lens would appear to be an ideal organ for maintaining culture conditions because of lacking blood vessels and nerves. The lens <italic>in vivo</italic> obtains its nutrients and eliminates waste products via diffusion with the surrounding fluids. Lens opacification observed <italic>in vivo</italic> can be mimicked <italic>in vitro</italic> by addition of the cataractogenic agent sodium selenite (Na2SeO3) to the culture medium. Moreover, since an overdose of sodium selenite induces also cataract in young rats, it became an extremely rapid and convenient model of nuclear cataract <italic>in vivo</italic>. The main focus of this review will be on selenium (Se) and its salt sodium selenite, their toxicological characteristics and safety data in relevance of modelling cataractogenesis, either under <italic>in vivo</italic> or <italic>in vitro</italic> conditions. The studies revealing the mechanisms of lens opacification induced by selenite are highlighted, the representatives from screening for potential anti-cataract agents are listed.</abstract>

Different experimental approaches in modelling cataractogenesis

<article-title>Different experimental approaches in modelling cataractogenesis</article-title>

{"article-title":"Different experimental approaches in modelling cataractogenesis"}

<abstract xml:lang="en"><title style='display:none'>Investigation of <italic>in vitro</italic> effects of ethephon and chlorpyrifos, either alone or in combination, on rat intestinal muscle contraction</title>A range of pesticides is widely used in pest management and the chances of exposure to multiple organophosphorus (OP) compounds simultaneously are high, especially from dietary and other sources. Although health hazards of individual OP insecticides have been relatively well characterized, there is lesser information on the interactive toxicity of multiple OP insecticides. The aim of this study is to elicit the possible interactions in case combined exposure of an OP pesticide chlorpyrifos (CPF) and a plant growth regulator ethephon (ETF) which are used worldwide. The ileum segments of 3 months old Wistar Albino male rats were used in isolated organ bath containing Tyrode solution. ETF and CPF were incubated (10-7 M concentration) separately or in combination with each other to ileum and their effects on acetylcholine-induced contractions were studied. The data obtained from this study show that, single and combined exposure to the agents caused agonistic interactions with regard to potency of ACh whereas they caused a decrease on Emax value of ACh. These findings suggest that exposure to these agents which have direct and indirect cholinergic effects, may cause developing clinical responses with small doses and earlier but the extent of toxicity will be lower.</abstract>

Investigation of  effects of ethephon and chlorpyrifos, either alone or in combination, on rat intestinal muscle contraction

National Food Reference Laboratory, Turkish Ministry of Agriculture and Rural Affairs, Fatih Sultan Mehmet Bulvari, Yenimahalle, Ankara, Turkey

Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ankara, Diskapi, Ankara, Turkey

<article-title>Investigation of <italic>in vitro</italic> effects of ethephon and chlorpyrifos, either alone or in combination, on rat intestinal muscle contraction</article-title>

<abstract xml:lang="en"><title style='display:none'>Effect of cytisine on some brain and hepatic biochemical parameters in spontaneously hypertensive rats</title>Tobacco smoking is a risk factor for variety of cardio-vascular diseases, such as hypertension, myocardial infarction, stroke and many others. It is of great importance for hypertensive patients to stop smoking. One of the medicines widely used for smoking cessation in Bulgaria is the original Bulgarian product Tabex®, which is developed on the basis of natural plant alkaloid cytisine. The aim of the following study was to ivestigate the effects of cytisine on some brain and hepatic biochemical parameters in spontaneously hypertensive rats (SHR), an widely used rodent model for human essential hypertension, and to compare the obtained results with their age-matched normotensive controls Wistar Kyoto (WKY). Multiple cytisine administration did not affect the activity of ethylmorphine-N-demethylase (EMND) and anylinehydroxylase (AH), as well as the quantity of cytochrome P 450, nor in WKY neither in SHR In the liver cytisine increased the MDA quantity both in SHR and in WKY, by 25% (<italic>p</italic>&lt;0.05) and by 29% (<italic>p</italic>&lt;0.05) respectively, while the GSH level was not significantly changed by the compound in both strains. In contrast, on the brain level, cytisine administration to SHR caused more prominent toxicity, resulted in GSH depletion and increased MDA quantity, while in WKY strain did not exert any toxicity. Cytisine did not significantly affect ALAT and ASAT activity in both strains. In conclusion, the results of our study suggest higher brain toxicity of cytisine in spontaneously hypertensive rats, that might be due to their pathophysiological characteristics.</abstract>

Effect of cytisine on some brain and hepatic biochemical parameters in spontaneously hypertensive rats

Laboratory of "Drug metabolism and drug toxicity", Department of Pharmacology and Toxicology, Faculty of Pharmacy, Medical University, Sofia, Bulgaria

<article-title>Effect of cytisine on some brain and hepatic biochemical parameters in spontaneously hypertensive rats</article-title>

Interdisciplinary Toxicology is covered by the following services: <UL> <LI>Baidu Scholar </LI> <LI>Cabell's Whitelist </LI> <LI>CABI (over 50 subsections) </LI> <LI>Case </LI> <LI>Chemical Abstracts Service (CAS) - CAplus </LI> <LI>Chemical Abstracts Service (CAS) - SciFinder </LI> <LI>CNKI Scholar (China National Knowledge Infrastructure) </LI> <LI>CNPIEC - cnpLINKer </LI> <LI>Dimensions </LI> <LI>DOAJ (Directory of Open Access Journals) </LI> <LI>EBSCO (relevant databases) </LI> <LI>EBSCO Discovery Service </LI> <LI>FSTA - Food Science &amp; Technology Abstracts </LI> <LI>Genamics JournalSeek </LI> <LI>Google Scholar </LI> <LI>ICAP Alcohol Information Databases </LI> <LI>Japan Science and Technology Agency (JST) </LI> <LI>J-Gate </LI> <LI>JournalGuide </LI> <LI>JournalTOCs </LI> <LI>KESLI-NDSL (Korean National Discovery for Science Leaders) </LI> <LI>Meta </LI> <LI>Microsoft Academic </LI> <LI>MyScienceWork </LI> <LI>Naver Academic </LI> <LI>Naviga (Softweco) </LI> <LI>Norwegian Register for Scientific Journals, Series and Publishers </LI> <LI>Primo Central (ExLibris) </LI> <LI>ProQuest (relevant databases) </LI> <LI>Publons </LI> <LI>PubMed </LI> <LI>PubMed Central </LI> <LI>QOAM (Quality Open Access Market) </LI> <LI>ReadCube </LI> <LI>Reaxys </LI> <LI>SCImago (SJR) </LI> <LI>SCOPUS </LI> <LI>Semantic Scholar </LI> <LI>Sherpa/RoMEO </LI> <LI>Summon (ProQuest) </LI> <LI>TDNet </LI> <LI>Ulrich's Periodicals Directory/ulrichsweb </LI> <LI>WanFang Data </LI> <LI>WorldCat (OCLC) </LI></UL>

Interdisciplinary Toxicology ist in den folgenden Services indiziert: <UL> <LI>Baidu Scholar </LI> <LI>Cabell's Whitelist </LI> <LI>CABI (over 50 subsections) </LI> <LI>Case </LI> <LI>Chemical Abstracts Service (CAS) - CAplus </LI> <LI>Chemical Abstracts Service (CAS) - SciFinder </LI> <LI>CNKI Scholar (China National Knowledge Infrastructure) </LI> <LI>CNPIEC - cnpLINKer </LI> <LI>Dimensions </LI> <LI>DOAJ (Directory of Open Access Journals) </LI> <LI>EBSCO (relevant databases) </LI> <LI>EBSCO Discovery Service </LI> <LI>FSTA - Food Science &amp; Technology Abstracts </LI> <LI>Genamics JournalSeek </LI> <LI>Google Scholar </LI> <LI>ICAP Alcohol Information Databases </LI> <LI>Japan Science and Technology Agency (JST) </LI> <LI>J-Gate </LI> <LI>JournalGuide </LI> <LI>JournalTOCs </LI> <LI>KESLI-NDSL (Korean National Discovery for Science Leaders) </LI> <LI>Meta </LI> <LI>Microsoft Academic </LI> <LI>MyScienceWork </LI> <LI>Naver Academic </LI> <LI>Naviga (Softweco) </LI> <LI>Norwegian Register for Scientific Journals, Series and Publishers </LI> <LI>Primo Central (ExLibris) </LI> <LI>ProQuest (relevant databases) </LI> <LI>Publons </LI> <LI>PubMed </LI> <LI>PubMed Central </LI> <LI>QOAM (Quality Open Access Market) </LI> <LI>ReadCube </LI> <LI>Reaxys </LI> <LI>SCImago (SJR) </LI> <LI>SCOPUS </LI> <LI>Semantic Scholar </LI> <LI>Sherpa/RoMEO </LI> <LI>Summon (ProQuest) </LI> <LI>TDNet </LI> <LI>Ulrich's Periodicals Directory/ulrichsweb </LI> <LI>WanFang Data </LI> <LI>WorldCat (OCLC) </LI></UL>

The Journal publishes Original Papers, Review Articles and Clinical Reports on research relating to the toxicity of chemicals and their mixtures at molecular, cellular, tissue, target organ and whole body level in vivo (by all routes of exposure) and in vitro/ex vivo. Focus is on all aspects of modern toxicology: studies of pharmacotoxicological and metabolic mechanisms, toxicogenomics and proteomics, pharmacokinetics, cytotoxicity, immunotoxicity, organ toxicity, developmental toxicity, carcinogenesis, mutagenesis, environmental toxicity and environmental health concerning humans (including epidemiological studies), predictive toxicology, risk assessment, environmental chemistry of pesticides and dioxins,forensic toxicology and alternative toxicity testing. <DIV align=left> Why subscribe and read <UL> <LI>The journal aims to provide the complete and reliable source of information on current developments in the field of toxicology and related disciplines. </LI></UL> Why submit The emphasis is on publishing quality articles rapidly and making them freely available to researchers worldwide. All published articles will be deposited immediately upon publication in widely and internationally recognized open access repository free of charge. Rejection Rate <UL> <LI>10% </LI></UL> Archiving Sciendo archives the contents of this journal in <A href="https://www.portico.org/">Portico</A> - digital long-term preservation service of scholarly books, journals and collections. Plagiarism Policy The editorial board is participating in a growing community of <A href="https://www.crossref.org/services/similarity-check/">Similarity Check System's</A> users in order to ensure that the content published is original and trustworthy. Similarity Check is a medium that allows for comprehensive manuscripts screening, aimed to eliminate plagiarism and provide a high standard and quality peer-review process. </DIV>

Editor-in-Chief: Prof. Miroslav Pohanka, PhD. DSc. Executive Editor-in-Chief: Mojmír Mach e-mail: <A href="mailto:mintertox_journal@setox.eu">mintertox_journal@setox.eu</A> Editorial Advisory Board Arturo R. Anadon, Department of Toxicology and Pharmacology, Faculty of Veterinary Medicine, Spain Radomír Nosáľ, Institute of Experimental Pharmacology & Toxicology, Slovak Academy of Sciences, Slovakia Russel J. Reiter, Department of Cellular and Structural Biology, The University of Texas Health Science Center, USA Christina Ruden, Department of Environmental Science and Analytical Chemistry (ACES), Stockholm University, Sweden Marie Stiborová, Department of Biochemistry, Faculty of Science, Charles University, Czech Republic Aristidis M. Tsatsakis, Director Toxicology & Forencic Sciences Dept., Faculty of Medicine, University of Crete, Greece Martin F. Wilks, SCAHT - Swiss Centre for Applied Human Toxicology, Universität Basel, Switzerland Editors General Toxicology, Pharmacology & Physiology Viktor Bauer, Slovakia Iveta Bernátová, Slovakia Felix Carvalho, Portugal Nancy Claude, France Robert D. Grubbs, USA Jaroslav Květina, Czech Republic Gabriela Nosáľová, Slovakia Thomas Weiser, Switzerland Michal Zeman, Slovakia Environmental Toxicology Heidi Foth, Germany Jyrki Liesivuori, Finland Zdeňka Svobodová, Czech Republic 　 Carcinogenesis & Xenobiochemistry Pavel Anzenbacher, Czech Republic David R. Cool, USA Eva Horváthová, Slovakia Jana Navarová, Slovakia Ladislav Šoltés, Slovakia Jan Vondráček, Czech Republic 　 In Vitro Toxicology Štefan Bezek, Slovakia Helena Kandarova, USA Miguel A. Sogorb, Spain Miloň Tichý, Czech Republic Military Toxicology James B. Lucot, USA Jiří Kassa, Czech Republic Ahmet Korkmaz, Turkey Developmental Toxicology Eva Cecilie Bonefeld-Jørgensen, Denmark Ingrid Brucknerová, Slovakia Peter G. Fedor-Freybergh, Slovakia Eduard Ujházy, Slovakia Language Editor Magda Kouřilová, Slovakia Technical Editor Mojmir Mach, Slovakia Publisher De Gruyter Poland Bogumiła Zuga 32A Str. 01-811 Warsaw, Poland

<DIV align=left> Open Access Statement The journal is an Open Access journal that allows a free unlimited access to all its contents without any restrictions upon publication to all users. <A href="https://sciendo-parsed-data-feed.s3.eu-central-1.amazonaws.com/INTOX/Copyright_Transfer.pdf">Open Access License</A> SCOPE Interdisciplinary Toxicology (iTox) publishes quarterly and is devoted to the publication of research results in all areas of Toxicology and related scientific disciplines: /science/toxicology/itox/authors/scope/. The primary mission of iTox is to assist Central and Eastern European researchers in communicating their achievements to the global scientific community, nevertheless, contributions from other regions of the world are by no means excluded. The journal is peer-reviewed, in electronic-only format. The language of the journal is English. MANUSCRIPT SUBMISSION Manuscripts preferred for publication in iTox are those which: <UL> <LI>Contain original work - which is not published elsewhere in any medium by the authors or anyone else, and is not under consideration for publication in any other medium. This restriction does not apply to review articles.</LI> <LI>Are focused on the core aims and scope of the journal - iTox is a scientific journal publishing fundamental research results from all fields of toxicology and related scientific disciplines.</LI> <LI>Are clearly and correctly written - should contain all essential features of a complete scientific paper, should be written in a clear, easy to understand manner, and be readable for a wide audience.</LI> <LI>Are written in English - should be clearly and grammatically written, in an easily readable style. Attention to detail of the language will avoid severe misunderstandings which might lead to rejection of the paper (Please note that authors who are not native-speakers of English can be provided with help in rewriting their contribution in correct English).</LI> <LI>Are delivered in electronic format Manuscripts should be submitted via <A href="http://ems.intertox.sav.sk/">Electronic Manuscript Submission</A>.</LI></UL> iTox publishes research articles, communications, review papers and book reviews. a) Research Articles b) Rapid Communications – short reports on new and exciting results of high urgency. Sending us a report of significant interest, authors are asked to provide an explanation in their cover letter describing in detail why their contribution should be handled via rapid channel c) Reviews – topical mini(reviews) as well as full critical reviews on important subjects reflecting new trends in chemistry are also included in this section d) Book reviews PEER REVIEW PROCESS All manuscripts sent via e-mail receive individual identification codes. The Managing Editor then sends it to an appropriate Editor. However a submission may be declined by the Managing Editor without review, if deemed inappropriate for reasons other than scientific merit. a) choice of reviewers The Editors of iTox, each responsible for different area of Toxicology, seek advice from experts of in the appropriate field. Research articles and communications are reviewed by a minimum of two reviewers, review papers by at least three. b) suggestions from authors Authors are requested to suggest persons competent to review their manuscript. However please note that this will be treated only as a suggestion, and the final selection of reviewers is exclusively the Editor’s decision. The Editors are fully responsible for decisions about manuscripts. The final decision whether to accept or reject a paper rests with them. The Managing Editor only communicates the final decision, and informs the authors about further processing. <A href="https://www.setox.eu/">www.setox.eu/</A> REVISED MANUSCRIPT SUBMISSION When revision of a manuscript is requested, authors should return the revised version of their manuscript as soon as possible. Prompt action may ensure fast publication if a paper is finally accepted for publication in iTox. If it is the first revision of an article authors need to return their revised manuscript within 60 days. If it is the second revision authors need to return their revised manuscript within 14 days. If these deadlines are not met, and no specific arrangements for completion have been made with the Editor, the manuscript will be treated as a new one and will receive a new identification code along with a new registration date. FINAL PROOFREADING Authors will receive a pdf file with the edited version of their manuscript for final proofreading. This is the last opportunity to view an article before its publication on the journal web site. No changes or modifications can be introduced once it is published. Thus authors are requested to check their proof pages carefully against manuscript within 3 working days and prepare a separate document containing all changes that should be introduced. Authors are sometimes asked to provide additional comments and explanations in response to remarks and queries from the language or technical editors. ONLINE FIRST SERVICE Manuscripts accepted for publication are published on-line in so called Online First service as soon as they are ready for publication (that is when final proofreading is performed by authors, and all concerns are resolved). Final manuscripts for publication may appear on the Web 1-2 months prior to regular issue publication. Once a manuscript appears on the Web site it is considered as published. REPRINTS After publication, the corresponding author is notified by email, and receives a pdf file with the published version of the manuscript. ERRATA If any errors are detected in the published material they should be reported to the Managing Editor. The corresponding authors should send appropriate corrected material to the Managing Editor via email. This material will be considered for publication in the earliest available issue of iTox. TRANSFER OF COPYRIGHT AGREEMENT A properly completed Transfer of Copyright Agreement must be provided for each submitted manuscript. Transfer of Copyrights Agreement should be signed, scanned and sent via email to the Managing Editor of the journal. Please read the terms of this agreement, print and then fll, sign and send a scanned document by email to the Managing Editor of this journal. </DIV>

Ausgaben

Zeitschriften und Ausgaben

Interdisciplinary Toxicology

Suche

Volumen 3 (2010): Heft 1 (March 2010)

Details zu Zeitschrift und Ausgabe

Suche

Artikel

Planen Sie Ihre Fernkonferenz mit Scienceendo