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Assessment of Biochemical Bone Turnover Markers in Polish Healthy Children and Adolescents

Joanna Gajewska
Joanna Gajewska
, 
Magdalena Chełchowska
Magdalena Chełchowska
, 
Grażyna Rowicka
Grażyna Rowicka
, 
Witold Klemarczyk
Witold Klemarczyk
, 
Ewa Głąb-Jabłońska
Ewa Głąb-Jabłońska
 und 
Jadwiga Ambroszkiewicz
Jadwiga Ambroszkiewicz
   | 19. Apr. 2024
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Article Category: Original research
Online veröffentlicht: 19. Apr. 2024
Seitenbereich: 14 - 22
Eingereicht: 27. Nov. 2023
Akzeptiert: 09. Feb. 2024
DOI: https://doi.org/10.34763/jmotherandchild.20242801.d-23-00105
Schlüsselwörter
© 2024 Joanna Gajewska et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.

Figure 1.

BALP (A), OC (B), and CTX-I (C) trend curves (polynomial trendlines: girls, boys -----) with individual data points for girls and boys aged 1–18 years old.
BALP (A), OC (B), and CTX-I (C) trend curves (polynomial trendlines: girls, boys -----) with individual data points for girls and boys aged 1–18 years old.

Bone markers in the studied population of children and adolescents.

Variable Girls Boys Total P*
Participants, n (%) 165 (46.5) 190 (53.5) 355 (100) 0.189
Age (years) 8.5 (5.5–12.0) 8.4 (5.5–13.0) 8.4 (5.5–12.3) 0.981
BALP (U/L) 106.6 (84.6–128.4) 115.4 (92.0–136.5) 112.1 (87.9–132.5) 0.048
OC (ng/mL) 84.0 (52.6–114.4) 80.9 (55.5–116.9) 83.2 (52.6–114.4) 0.518
CTX-I (ng/mL) 1.72 (1.12.–2.22) 1.67 (1.22.–2.09) 1.70 (1.19–2.12) 0.805

Relations between BMI Z-score, bone markers and densitometric parameters in prepubertal healthy children aged 5–10 years old.

Parameters TBLH-BMD r (p) TBLH-BMD Z-score r (p) TBLH-BMC r (p) L1-L4 BMD r (p) L1-L4 BMD Z-score r (p)
BMI Z-score 0.282 (0.008) 0.366 (<0.001) 0.266 (0.012) 0.248 (0.021) 0.265 (0.014)
BALP −0.049 (0.651) −0.092 (0.398) −0.032 (0.769) −0.019 (0.861) 0.006 (0.95)
OC 0.329 (0.002) 0.245 (0.023) 0.329 (0.002) 0.280 (0.009) 0.192 (0.077)
CTX-I 0.078 (0.476) 0.048 (0.661) 0.101 (0.356) 0.097 (0.374) 0.051 (0.051)

Bone markers in children and adolescents aged 1–18 years old stratified by sex and age.

Parameter/years Girls (n=165) Boys (n=190) p
n Median Range n Median Range
BALP (U/L)
1.0–2.9 10 139.5 122.8–143.9 14 126.7 116.3–170.2 0.861
3.0–4.9 20 112.8 86.7–138.3 19 125.5 100.7–142.4 0.227
5.0–7.9 43 117.9 102.5–132.1 53 118.7 103.6–138.8 0.945
8.0–9.9 32 118.8 98.4–128.0 33 109.7 94.8–125.7 0.568
10.0–11.9 16 109.4 97.2–129.9 14 118.6 88.3–152.7 0.618
12.0–13.9 10 120.7 101.0–138.8 18 129.1 101.8–190.1 0.598
14.0–15.9 12 67.2 49.5–84.4 18 120.9 99.3–134.4 <0.001
16.0–18.0 22 34.2 20.7–39.7 21 44.1 30.8–71.6 0.022
OC (ng/mL)
1.0–2.9 10 72.0 62.6–118.0 14 57.8 41.3–81.8 0.160
3.0–4.9 20 89.7 53.7–113.5 19 62.5 52.4–77.1 0.092
5.0–7.9 43 77.3 58.0–105.7 53 77.4 62.8–116.6 0.749
8.0–9.9 32 95.6 69.9–126.1 33 92.2 74.0–110.0 0.436
10.0–11.9 16 114.8 95.7–127.1 14 101.0 66.2–132.3 0.406
12.0–13.9 10 88.8 77.9–111.2 18 122.5 96.0–135.8 0.019
14.0–15.9 12 73.5 59.0–110.0 18 122.0 110.5–134.0 0.010
16.0–18.0 22 30.4 23.2–41.3 21 38.8 30.3–49.5 0.018
CTX-I (ng/mL)
1.0–2.9 10 1.58 1.05–2.22 14 1.40 0.90–1.59 0.266
3.0–4.9 20 1.94 1.23–2.37 19 1.66 1.21–2.02 0.369
5.0–7.9 43 1.80 1.25–2.17 53 1.85 1.33–2.14 0.651
8.0–9.9 32 1.80 1.43–2.25 33 1.67 1.49–1.98 0.240
10.0–11.9 16 2.23 1.72–2.43 14 1.91 1.79–2.19 0.383
12.0–13.9 10 1.74 1.47–2.64 18 2.13 1.41–2.66 0.905
14.0–15.9 12 1.37 0.95–1.79 18 2.19 1.96–2.50 0.004
16.0–18.0 22 0.72 0.41–0.97 21 0.86 0.64–0.95 0.375

Serum bone marker concentrations and anthropometric parameters in prepubertal healthy children aged 5–10 years old.

Variable Girls n=45 Boys n=43 Total n=88 p*
Age (years) 8.2 (6.8–9.1) 7.5 (5.6–9.0) 8.0 (6.0–9.1) 0.081
Weight (kg) 27.0 (21.3–29.4) 23.9 (20.3–29.9) 25.1 (20.4–29.7) 0.361
Height (cm) 128.5 (119.0–133.8) 125.6 (117.8–132.6) 126.4 (118.6–133.5) 0.278
BMI (kg/m2) 15.5 (14.5–17.0) 15.6 (14.6–16.6) 15.5 (14.6–16.8) 0.910
BMI Z–score −0.36 (−0.70–0.24) −0.37 (−0.75–0.04) −0.37 (−0.74–0.18) 0.841
TBLH-BMD (g/cm2) 0.686 (0.642–0.737) 0.644 (0.622–0.720) 0.672 (0.627–0.730) 0.246
TBLH-BMD Z-score −0.40 (−0.70–0.20) −0.10 (−0.60–0.40) −0.30 (−0.63–0.20) 0.101
TBLH-BMC (g) 600.6 (452.8–764.5) 526.2 (419.4–751.3) 582.8 (436.2–760.3) 0.258
L1-L4 BMD (g/cm2) 0.666 (0.631–0.731) 0.624 (0.569–0.707) 0.659 (0.595–0724) 0.057
L1-L4 BMD Z-score −0.40 (−0.80–0.30) −0.40 (−1.20–0.20) −0.4 (−1.00–0.20) 0.296
BALP (U/L) 119.8 (100.3–131.3) 116.7 (102.0–130.5) 117.9 (100.3–131.4) 0.799
OC (ng/mL) 81.2 (63.8–102.7) 75.2 (63.5–94.4) 77.5 (63.7–100.5) 0.450
CTX-I (ng/mL) 1.78 (1.37–2.16) 1.66 (1.44–2.00) 1.73 (1.39–2.02) 0.419
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Sprache:
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Fachgebiete der Zeitschrift:
Medizin, Klinische Medizin, Kinder- und Jugendmedizin, Kinderhämatolgie und -Onkologie, Öffentliches Gesundheitswesen
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