Assessment of Biochemical Bone Turnover Markers in Polish Healthy Children and Adolescents
Article Category: Original research
Publié en ligne: 19 avr. 2024
Pages: 14 - 22
Reçu: 27 nov. 2023
Accepté: 09 févr. 2024
© 2024 Joanna Gajewska et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
Bone markers in the studied population of children and adolescents.
Variable |
Girls |
Boys |
Total |
P* |
Participants, n (%) |
165 (46.5) |
190 (53.5) |
355 (100) |
0.189 |
Age (years) |
8.5 (5.5–12.0) |
8.4 (5.5–13.0) |
8.4 (5.5–12.3) |
0.981 |
BALP (U/L) |
106.6 (84.6–128.4) |
115.4 (92.0–136.5) |
112.1 (87.9–132.5) |
0.048 |
OC (ng/mL) |
84.0 (52.6–114.4) |
80.9 (55.5–116.9) |
83.2 (52.6–114.4) |
0.518 |
CTX-I (ng/mL) |
1.72 (1.12.–2.22) |
1.67 (1.22.–2.09) |
1.70 (1.19–2.12) |
0.805 |
Relations between BMI Z-score, bone markers and densitometric parameters in prepubertal healthy children aged 5–10 years old.
Parameters |
TBLH-BMD r (p) |
TBLH-BMD Z-score r (p) |
TBLH-BMC r (p) |
L1-L4 BMD r (p) |
L1-L4 BMD Z-score r (p) |
BMI Z-score |
0.282 (0.008) |
0.366 (<0.001) |
0.266 (0.012) |
0.248 (0.021) |
0.265 (0.014) |
BALP |
−0.049 (0.651) |
−0.092 (0.398) |
−0.032 (0.769) |
−0.019 (0.861) |
0.006 (0.95) |
OC |
0.329 (0.002) |
0.245 (0.023) |
0.329 (0.002) |
0.280 (0.009) |
0.192 (0.077) |
CTX-I |
0.078 (0.476) |
0.048 (0.661) |
0.101 (0.356) |
0.097 (0.374) |
0.051 (0.051) |
Bone markers in children and adolescents aged 1–18 years old stratified by sex and age.
Parameter/years |
Girls (n=165) |
Boys (n=190) |
p |
|
|
n |
Median |
Range |
n |
Median |
Range |
BALP (U/L) |
1.0–2.9 |
10 |
139.5 |
122.8–143.9 |
14 |
126.7 |
116.3–170.2 |
0.861 |
3.0–4.9 |
20 |
112.8 |
86.7–138.3 |
19 |
125.5 |
100.7–142.4 |
0.227 |
5.0–7.9 |
43 |
117.9 |
102.5–132.1 |
53 |
118.7 |
103.6–138.8 |
0.945 |
8.0–9.9 |
32 |
118.8 |
98.4–128.0 |
33 |
109.7 |
94.8–125.7 |
0.568 |
10.0–11.9 |
16 |
109.4 |
97.2–129.9 |
14 |
118.6 |
88.3–152.7 |
0.618 |
12.0–13.9 |
10 |
120.7 |
101.0–138.8 |
18 |
129.1 |
101.8–190.1 |
0.598 |
14.0–15.9 |
12 |
67.2 |
49.5–84.4 |
18 |
120.9 |
99.3–134.4 |
<0.001 |
16.0–18.0 |
22 |
34.2 |
20.7–39.7 |
21 |
44.1 |
30.8–71.6 |
0.022 |
OC (ng/mL) |
1.0–2.9 |
10 |
72.0 |
62.6–118.0 |
14 |
57.8 |
41.3–81.8 |
0.160 |
3.0–4.9 |
20 |
89.7 |
53.7–113.5 |
19 |
62.5 |
52.4–77.1 |
0.092 |
5.0–7.9 |
43 |
77.3 |
58.0–105.7 |
53 |
77.4 |
62.8–116.6 |
0.749 |
8.0–9.9 |
32 |
95.6 |
69.9–126.1 |
33 |
92.2 |
74.0–110.0 |
0.436 |
10.0–11.9 |
16 |
114.8 |
95.7–127.1 |
14 |
101.0 |
66.2–132.3 |
0.406 |
12.0–13.9 |
10 |
88.8 |
77.9–111.2 |
18 |
122.5 |
96.0–135.8 |
0.019 |
14.0–15.9 |
12 |
73.5 |
59.0–110.0 |
18 |
122.0 |
110.5–134.0 |
0.010 |
16.0–18.0 |
22 |
30.4 |
23.2–41.3 |
21 |
38.8 |
30.3–49.5 |
0.018 |
CTX-I (ng/mL) |
1.0–2.9 |
10 |
1.58 |
1.05–2.22 |
14 |
1.40 |
0.90–1.59 |
0.266 |
3.0–4.9 |
20 |
1.94 |
1.23–2.37 |
19 |
1.66 |
1.21–2.02 |
0.369 |
5.0–7.9 |
43 |
1.80 |
1.25–2.17 |
53 |
1.85 |
1.33–2.14 |
0.651 |
8.0–9.9 |
32 |
1.80 |
1.43–2.25 |
33 |
1.67 |
1.49–1.98 |
0.240 |
10.0–11.9 |
16 |
2.23 |
1.72–2.43 |
14 |
1.91 |
1.79–2.19 |
0.383 |
12.0–13.9 |
10 |
1.74 |
1.47–2.64 |
18 |
2.13 |
1.41–2.66 |
0.905 |
14.0–15.9 |
12 |
1.37 |
0.95–1.79 |
18 |
2.19 |
1.96–2.50 |
0.004 |
16.0–18.0 |
22 |
0.72 |
0.41–0.97 |
21 |
0.86 |
0.64–0.95 |
0.375 |
Serum bone marker concentrations and anthropometric parameters in prepubertal healthy children aged 5–10 years old.
Variable |
Girls n=45 |
Boys n=43 |
Total n=88 |
p* |
Age (years) |
8.2 (6.8–9.1) |
7.5 (5.6–9.0) |
8.0 (6.0–9.1) |
0.081 |
Weight (kg) |
27.0 (21.3–29.4) |
23.9 (20.3–29.9) |
25.1 (20.4–29.7) |
0.361 |
Height (cm) |
128.5 (119.0–133.8) |
125.6 (117.8–132.6) |
126.4 (118.6–133.5) |
0.278 |
BMI (kg/m2) |
15.5 (14.5–17.0) |
15.6 (14.6–16.6) |
15.5 (14.6–16.8) |
0.910 |
BMI Z–score |
−0.36 (−0.70–0.24) |
−0.37 (−0.75–0.04) |
−0.37 (−0.74–0.18) |
0.841 |
TBLH-BMD (g/cm2) |
0.686 (0.642–0.737) |
0.644 (0.622–0.720) |
0.672 (0.627–0.730) |
0.246 |
TBLH-BMD Z-score |
−0.40 (−0.70–0.20) |
−0.10 (−0.60–0.40) |
−0.30 (−0.63–0.20) |
0.101 |
TBLH-BMC (g) |
600.6 (452.8–764.5) |
526.2 (419.4–751.3) |
582.8 (436.2–760.3) |
0.258 |
L1-L4 BMD (g/cm2) |
0.666 (0.631–0.731) |
0.624 (0.569–0.707) |
0.659 (0.595–0724) |
0.057 |
L1-L4 BMD Z-score |
−0.40 (−0.80–0.30) |
−0.40 (−1.20–0.20) |
−0.4 (−1.00–0.20) |
0.296 |
BALP (U/L) |
119.8 (100.3–131.3) |
116.7 (102.0–130.5) |
117.9 (100.3–131.4) |
0.799 |
OC (ng/mL) |
81.2 (63.8–102.7) |
75.2 (63.5–94.4) |
77.5 (63.7–100.5) |
0.450 |
CTX-I (ng/mL) |
1.78 (1.37–2.16) |
1.66 (1.44–2.00) |
1.73 (1.39–2.02) |
0.419 |