Preoperative serum CA-125 level as a predictor for the extent of cytoreduction in patients with advanced stage epithelial ovarian cancer
, , und | 10. Aug. 2021
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Article Category: Research Article
Online veröffentlicht: 10. Aug. 2021
Seitenbereich: 341 - 346
Eingereicht: 25. Nov. 2020
Akzeptiert: 09. Feb. 2021
DOI: https://doi.org/10.2478/raon-2021-0013
© 2021 Sebastjan Merlo, Nikola Besic, Eva Drmota, Nina Kovacevic, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Median and range CA-125 levels in different surgical outcomes in primary debulking surgery (PDS) and = neoadjuvant chemotherapy (NACT) group
| Surgical outcomes | PDS (N = 38) | NACT (N = 215) | |
|---|---|---|---|
| Complete gross resection | 359 |
943 |
0.006 |
| Optimal resection | 512 |
1006 |
|
| Suboptimal resection | 1522 |
1063 |
|
| Complete gross resection | 25 |
0.020 | |
| Optimal resection | 36 |
||
| Suboptimal resection | 68 |
Clinical characteristics (N = 253)
| Characteristic | PDS (N = 38) | NACT (N = 215) | |
|---|---|---|---|
| Median | 53.7 | 62.2 | < 0.001 |
| Range | 29–84 | 39–85 | |
| Median | 24.5 | 23.8 | 0.210 |
| Range | 17.4–45.2 | 18.2–32.1 | |
| Median | 2 | 2 | 0.080 |
| Range | 0–5 | 0–4 | |
| Median | 50 | 51.5 | 0.340 |
| Range | 37–60 | 45–58 | |
| 1 | 7 (18.4) | 23 (10.7) | 0.780 |
| 2 | 22 (57.9) | 141 (65.6) | |
| 3 | 9 (23.7) | 49 (22.8) | |
| 4 | 0 (0) | 2 (0.9) | |
| 0 | 26 (68.4) | 96 (44.7) | 0.130 |
| 1 | 8 (21.0) | 85 (40.0) | |
| 2 | 4 (10.6) | 26 (12.1) | |
| 3 | 0 (0) | 5 (2.3) | |
| 4 | 0 (0) | 3 (1.4) | |
| IIIC | 34 (89.5) | 143 (66.6) | 0.010 |
| IV | 4 (10.5) | 72 (33.4) | |
| Serous | 32 (84.2) | 202 (94.0) | 0.100 |
| Endometrioid | 6 (15.8) | 8 (3.7) | |
| Mucinous | 0 (0) | 3 (1.4) | |
| Clear-cell | 0 (0) | 2 (0.9) | |
| Median | 499 | 972 | 0.058 |
| Range | 59–5739 | 10–31481 | |
| Complete gross resection | 9 (23.7) | 124 (57.6) | 0.002 |
| Optimal visible residual (≤1 cm) | 7 (18.4) | 30 (14.0) | |
| Suboptimal (>1 cm) | 22 (57.9) | 61 (28.4) | |
| Median | 10 | 9 | 0.555 |
| Range | 7–28 | 5–59 |
Statistical cut off values of serum CA-125 level and probability to obtain complete gross or optimal cytoreduction
| CA-125 level (IU/ml) | Sensitivity (%) | Number and percentage of patients | |
|---|---|---|---|
| 50 | 96.5 | 9 | 3.5 % |
| 100 | 86.5 | 33 | 13.0 % |
| 250 | 74.0 | 66 | 26.1 % |
| 500 | 58.0 | 98 | 38.7 % |
| 750 | 50.0 | 128 | 50.6 % |
| 1000 | 42.0 | 150 | 59.3 % |