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Electric cell-substrate impedance sensing in biocompatibility research

Andrzej Kociubiński

Andrzej Kociubiński

Department of Electronics and Information Technology, Lublin University of TechnologyLublin, Poland
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Kociubiński, Andrzej
  
30. Dez. 2021
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Online veröffentlicht: 30. Dez. 2021
Seitenbereich: 163 - 168
Eingereicht: 30. Nov. 2021
DOI: https://doi.org/10.2478/joeb-2021-0019
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© 2021 Andrzej Kociubiński, published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.

Fig.1

Impedance response (normalized) of mouse fibroblast cells on measured by an ECIS sensor array with a golden electrode at 16 kHz, showing various cellular morphological changes.
Impedance response (normalized) of mouse fibroblast cells on measured by an ECIS sensor array with a golden electrode at 16 kHz, showing various cellular morphological changes.

Fig. 2

The technological mask design of the cell impedance measurement test substrate, compatible with the base station of a commercial measurement device (a) view of the whole substrate, (b) single pair of electrodes, (c) photo of the copper electrodes taken with a Keyence VHX 5000 optical microscope.
The technological mask design of the cell impedance measurement test substrate, compatible with the base station of a commercial measurement device (a) view of the whole substrate, (b) single pair of electrodes, (c) photo of the copper electrodes taken with a Keyence VHX 5000 optical microscope.

Fig. 3

Impedance response measured by an ECIS sensor array with Ti, NiCr, and Cu electrodes at 16 kHz.
Impedance response measured by an ECIS sensor array with Ti, NiCr, and Cu electrodes at 16 kHz.

Fig. 4

Nichrome capacitor electrode with the dead cells after the experiment (magnification ×100).
Nichrome capacitor electrode with the dead cells after the experiment (magnification ×100).
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Englisch
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Technik, Bioingenieurwesen, Biomedizinische Elektronik, Biologie, Biophysik, Medizin, Biomedizinische Technik, Physik, Spektroskopie und Metrologie
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