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Biosensor of inflammation biomarkers based on electrical bioimpedance analysis on immobilized DNA without chemical modification

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25. Juni 2020

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COVER HERUNTERLADEN

Fig. 1

Components of the cDNA biosensor system.
Components of the cDNA biosensor system.

Fig. 2

Diagram of functionalized gold surface quartz crystal and representation of the cDNA anchorage and hybridization.
Diagram of functionalized gold surface quartz crystal and representation of the cDNA anchorage and hybridization.

Fig. 3

Nyquiste plot EBiS spectra for the three genes studied (NLRP3, IL-1B and Caspase 1) as well as control (vehicle) and negative control (non-specific gene) conditions.
Nyquiste plot EBiS spectra for the three genes studied (NLRP3, IL-1B and Caspase 1) as well as control (vehicle) and negative control (non-specific gene) conditions.

Fig. 4

Relative integrated EBiS vs relative qPCR expression of the genes NLRP3, IL-1β, and Casp-1. One-way ANOVA test *p<0.01, **p<0.05.
Relative integrated EBiS vs relative qPCR expression of the genes NLRP3, IL-1β, and Casp-1. One-way ANOVA test *p<0.01, **p<0.05.

Fig. 5

Numerical modelling of a simple DNA molecule anchoring on an electrode surface. Frequency response of the RC equivalent circuit calculated by LTspice IV.
Numerical modelling of a simple DNA molecule anchoring on an electrode surface. Frequency response of the RC equivalent circuit calculated by LTspice IV.
Sprache:
Englisch
Zeitrahmen der Veröffentlichung:
1 Hefte pro Jahr
Fachgebiete der Zeitschrift:
Technik, Bioingenieurwesen, Biomedizinische Elektronik, Biologie, Biophysik, Medizin, Biomedizinische Technik, Physik, Spektroskopie und Metrologie