Potential role of plant polysaccharides as immunostimulants in aquaculture: a review

Akbari-Alavijeh, S., Soleimanian-Zad, S., Sheikh-Zeinoddin, M., Hashmi, S. (2018). Pistachio hull water-soluble polysaccharides as a novel prebiotic agent. Int. J. Biol. Macromol., 107: 808-816.10.1016/j.ijbiomac.2017.09.049 Search in Google Scholar

Bai, D., Wu, X., Guo, Y., Zhu, G., Xing, K., Ning, B. (2011). Effect of astragalus polysaccharides on antioxidant and nonspecific immune indices of yellow catfish (Pelteobagrus fulvidraco) over long-term feeding. Chin. J. Clin. Nutr., 23(9): 1622-1630. Search in Google Scholar

Bai, D., Wu, X., Zhu, G., Guo, Y., Yang, G., Ning, B., Xing, K. (2012). Astragalus polysaccharides enhance cellular immune response and disease resistance in yellow catfish. Isr. J. Aquac. - Bamidgeh., 64.2012.688.10.46989/001c.20642 Search in Google Scholar

Bouteraa, M.T., Mishra, A., Romdhane, W.B., Hsouna, A.B., Siddique, K.H., Saad, R.B. (2022). Bio-stimulating effect of natural polysaccharides from Lobularia maritima on Durum Wheat seedlings: Improved plant growth, salt stress tolerance by modulating biochemical responses and ion homeostasis. Plants, 11(15):1991.10.3390/plants11151991 Search in Google Scholar

Çelik, İ., Demirer, G. N. (2015). Biogas production from pistachio (Pistacia vera L.) processing waste. Biocatal. Agric. Biotechno., 4(4): 767-772.10.1016/j.bcab.2015.10.009 Search in Google Scholar

Chang, Z.Q., Ge, Q.Q., Sun, M., Wang, Q., Lv, H.Y., Li, J., (2018). Immune responses by dietary supplement with Astragalus polysaccharides in the Pacific white shrimp, Litopenaeus vannamei. Aquac. Nutr., 24(2): 702-711.10.1111/anu.12599 Search in Google Scholar

Chen, H., Chen, X., Ping, Z., Jiang, X., Ge, M., Ma, J., Yu, W. (2022). Promotion Effect of Angelica Sinensis extract on angiogenesis of chicken preovulatory follicles in vitro. Poult. Sci., 101938. https://doi.org/10.1016/j.psj.2022.101938.10.1016/j.psj.2022.101938918922135679671 Search in Google Scholar

Chen, H., Zhou, X., Zhang, J. (2014). Optimization of enzyme assisted extraction of polysaccharides from Astragalus membranaceus. Carbohydr. Polym., 111: 567-575.10.1016/j.carbpol.2014.05.033 Search in Google Scholar

Chen, R. Z., Tan, L., Jin, C. G., Lu, J., Tian, L., Chang, Q. Q., Wang, K. (2015). Extraction, isolation, characterization and antioxidant activity of polysaccharides from Astragalus membranaceus. Ind Crops Prod., 77: 434-443.10.1016/j.indcrop.2015.08.006 Search in Google Scholar

Chen, R., Jin, C., Tong, Z., Lu, J., Tan, L., Tian, L., Chang, Q. (2016). Optimization extraction, characterization and antioxidant activities of pectic polysaccharide from tangerine peels. Carbohydr. Polym., 136: 187-197.10.1016/j.carbpol.2015.09.036 Search in Google Scholar

Cheng, X., Lu, Y., Song, Y., Zhang, R., ShangGuan, X., Xu, H., Liu, H. (2021). Analysis of antibiotic resistance genes, environmental factors, and microbial community from aquaculture farms in five provinces, China. Front. Microbiol., 12: 1523. https://doi.org/10.3389/fmicb.2021.679805.10.3389/fmicb.2021.679805826455634248893 Search in Google Scholar

Cheng, Y., (2019). The growth performance and nonspecific immunity of red swamp crayfish Procambarus clarkia affected by dietary Rhodiola rosea polysaccharide. Fish Shellfish Immunol., 93: 796-800.10.1016/j.fsi.2019.08.046 Search in Google Scholar

Citarasu, T. (2010). Herbal biomedicines: a new opportunity for aquaculture industry. Aquac Int., 18(3): 403-414.10.1007/s10499-009-9253-7 Search in Google Scholar

Cui, Q., Zhao, Z., Yuan, C. (2020). Effects of astragalus polysaccharides on hemocytes phagocytosis and gene expression of immune-related factors in Eriocheir sinensis. Aquac Int., 28(5): 1787-1796.10.1007/s10499-020-00557-6 Search in Google Scholar

Demin, G. A. O. (2010). Analysis of nutritional components of Taraxacum mongolicum and its antibacterial activity. Pharmacogn. Mag., 2(12): 502-505.10.1016/S0975-3575(10)80039-2 Search in Google Scholar

Dong, B., Wu, L., Chen, Q., Xu, W., Li, D., Han, D., Jin, J. (2022). Tolerance assessment of Atractylodes macrocephala polysaccharide in the diet of largemouth bass (Micropterus salmoides). Antioxidants., 11(8): 1581. https://doi.org/10.3390/antiox11081581.10.3390/antiox11081581940485836009300 Search in Google Scholar

Dongqing, B., Xuan, W., Yuhua, L. (2011). The effects of Lycium bararum polysaccharides and Ganoderma lucidum polysaccharides on the antioxidant abilities and nonspecific immunity on white cloud mountain fish. China Feed, 1. Search in Google Scholar

Du, J., Li, J., Zhu, J., Huang, C., Bi, S., Song, L., Yu, R. (2018). Structural characterization and immunomodulatory activity of a novel polysaccharide from Ficus carica. Food Funct., 9(7): 3930-3943.10.1039/C8FO00603B Search in Google Scholar

Du, M., Hu, X., Kou, L., Zhang, B., Zhang, C. (2016). Lycium barbarum polysaccharide mediated the antidiabetic and antinephritic effects in diet-streptozotocin-induced diabetic Sprague Dawley rats via regulation of NF-κB. Biomed Res. Int., 3140290, https://doi.org/10.1155/2016/3140290.10.1155/2016/3140290485688927200371 Search in Google Scholar

Fan, Y. (2010). Effects of polysaccharides from Astragalus membranaceus on non-specific immune in sea cucumber Apostichopus japonicus. Fish Sci (China)., 29: 321-324. Search in Google Scholar

Fan, Y., Wang, X., Wang, Y., Liu, H., Yu, X., Li, L., Ye, H., Wang, S., Gai, C., Xu, L., Diao, J. (2021). Potential effects of dietary probiotics with Chinese herb polysaccharides on the growth performance, immunity, disease resistance, and intestinal microbiota of rainbow trout (Oncorhynchus mykiss). J. World Aquac. Soc., 52(6): 1194-1208.10.1111/jwas.12757 Search in Google Scholar

Fan, Y., Yu, X., Wang, S., Xu, L., Li, T., Ye, H., Yang, X., Wang, Y. (2012). Application of different forms of Astragalus polysaccharide in sea cucumber Apostichopus japonicus aquaculture. Fish Sci (Dalian)., 31(11): 663-667. Search in Google Scholar

Farag, M.R., Alagawany, M., Khalil, S.R., Moustafa, A.A., Mahmoud, H.K., Abdel-Latif, H.M. (2021). Astragalus membranaceus polysaccharides modulate growth, hemato-biochemical indices, hepatic antioxidants, and expression of HSP70 and apoptosis-related genes in Oreochromis niloticus exposed to sub-lethal thallium toxicity. Fish Shellfish Immunol., 118: 251-260.10.1016/j.fsi.2021.09.009 Search in Google Scholar

Farag, M.R., Attia, Y.A., Al Solami, L.S., Bovera, F., Nizza, A., Alagawany, M. (2022). Behavioral, physiological, and inflammatory responses of Oreochromis niloticus fish exposed to thallium and/or supplementation with Astragalus membranaceus polysaccharides. Aquaculture., 553: 738100.10.1016/j.aquaculture.2022.738100 Search in Google Scholar

Feng, J.C., Cai, Z.L., Zhang, X.P., Chen, Y.Y., Chang, X.L., Wang, X.F., Qin, C.B., Yan, X., Ma, X., Zhang, J.X., Nie, G.X. (2020). The effects of oral Rehmannia glutinosa polysaccharide administration on immune responses, antioxidant activity and resistance against Aeromonas hydrophila in the common carp, Cyprinus carpio L. Front. Immunol., 11: 904.10.3389/fimmu.2020.00904 Search in Google Scholar

Fu, L., Zhou, G., Pan, J., Li, Y., Lu, Q., Zhou, J., Li, X. (2017). Effects of Astragalus polysaccharides on antioxidant abilities and non-specific immune responses of Chinese mitten crab, Eriocheir sinensis. Aquac Int., 25(3): 1333-1343.10.1007/s10499-017-0117-2 Search in Google Scholar

Gabriel, N. N., Wilhelm, M. R., Habte-Tsion, H. M., Chimwamurombe, P., Omoregie, E., Iipinge, L. N., Shimooshili, K. (2019b). Effect of dietary Aloe vera polysaccharides supplementation on growth performance, feed utilization, hemato-biochemical parameters, and survival at low pH in African catfish (Clarias gariepinus) fingerlings. Int. Aquat. Res., 11(1): 57-72.10.1007/s40071-019-0219-8 Search in Google Scholar

Gabriel, N.N., Wilhelm, M.R., Habte-Tsion, H.M., Chimwamurombe, P., Omoregie, E. (2019a). Dietary garlic (Allium sativum) crude polysaccharides supplementation on growth, haematological parameters, whole body composition and survival at low water pH challenge in African catfish (Clarias gariepinus) juveniles. Sci. Afr., 5: e00128.10.1016/j.sciaf.2019.e00128 Search in Google Scholar

Gao, Y., Wei, Y., Wang, Y., Gao, F., Chen, Z. (2017). Lycium barbarum: a traditional Chinese herb and a promising anti-aging agent. Aging Dis., 8(6): 778.10.14336/AD.2017.0725 Search in Google Scholar

Gharibzahedi, S. M. T., Smith, B., Guo, Y. (2019). Ultrasound-microwave assisted extraction of pectin from fig (Ficus carica L.) skin: Optimization, characterization and bioactivity. Carbohydr. Polym., 222: 114992.10.1016/j.carbpol.2019.114992 Search in Google Scholar

Guo, H., Zhang, W., Jiang, Y., Wang, H., Chen, G., Guo, M. (2019). Physicochemical, structural, and biological properties of polysaccharides from dandelion. Molecules., 24(8): 1485.10.3390/molecules24081485 Search in Google Scholar

Hamed, M., Bougatef, H., Karoud, W., Krichen, F., Haddar, A., Bougatef, A., Sila, A. (2020). Polysaccharides extracted from pistachio external hull: Characterization, antioxidant activity and potential application on meat as preservative. Ind. Crops Prod., 148: 112315.10.1016/j.indcrop.2020.112315 Search in Google Scholar

Harikrishnan, R., Devi, G., Van Doan, H., Tapingkae, W., Balasundaram, C., Arockiaraj, J. Ringø, E. (2022). Changes in immune genes expression, immune response, digestive enzymesantioxidant status, and growth of catla (Catla catla) fed with Astragalus polysaccharides against edwardsiellosis disease. Fish Shellfish Immunol., 121: 418-436.10.1016/j.fsi.2022.01.022 Search in Google Scholar

Hong, X., Lu, H., Zhang, Q., Xia, S., Tang, J., Ding, Z., Xue, H., Tang, J. (2014). Effect of Astragalus polysaccharide on the anti-infection of white spot syndrome virus (WSSV) in Procambarus clarkia. J. Shanghai Ocean Univ., 23(3): 423-428. Search in Google Scholar

Hoseinifar, S.H., Jahazi, M.A., Mohseni, R., Yousefi, M., Bayani, M., Mazandarani, M., Van Doan, H., El-Haroun, E.R. (2021). Dietary apple peel-derived pectin improved growth performance, antioxidant enzymes and immune response in common carp, Cyprinus carpio (Linnaeus, 1758). Aquaculture., 535: 736311.10.1016/j.aquaculture.2020.736311 Search in Google Scholar

Hosseini, S.M., Hoseinifar, S.H., Mazandarani, M., Paknejad, H., Van Doan, H., El-Haroun, E.R. (2020). The potential benefits of orange peels derived pectin on serum and skin mucus immune parameters, antioxidant defence and growth performance in common carp (Cyprinus carpio). Fish Shellfish Immunol., 103: 17-22.10.1016/j.fsi.2020.04.019 Search in Google Scholar

Huang, H., Pan, L., Pan, S., Song, M. (2018). Effects of dietary herbal formulae combined by Astragalus polysaccharides, chlorogenic acid and allicin in different combinations and proportions on growth performance, non‐specific immunity, antioxidant status, vibriosis resistance and damage indexes of Litopenaeus vannamei. Aquac. Res., 49(2): 701-716.10.1111/are.13500 Search in Google Scholar

Jia, R., Cao, L., Xu, P., Jeney, G., Yin, G. (2012). In vitro and in vivo hepatoprotective and antioxidant effects of Astragalus polysaccharides against carbon tetrachloride-induced hepatocyte damage in common carp (Cyprinus carpio). Fish Physiol. Biochem., 38(3): 871-881.10.1007/s10695-011-9575-z Search in Google Scholar

Jia, Y. Y., Guan, R. F., Wu, Y. H., Yu, X. P., Lin, W. Y., Zhang, Y. Y., Zhao, Y. (2014). Taraxacum mongolicum extract exhibits a protective effect on hepatocytes and an antiviral effect against hepatitis B virus in animal and human cells. Mol. Med. Rep., 9(4): 1381-1387.10.3892/mmr.2014.1925 Search in Google Scholar

Jin, Q.R., Mao, J.W., Zhu, F. (2022). The effects of Anoectochilus roxburghii polysaccharides on the innate immunity and disease resistance of Procambarus clarkii. Aquaculture., 555: 738210. https://doi.org/10.1016/j.aquaculture.2022.738210.10.1016/j.aquaculture.2022.738210 Search in Google Scholar

Kulkarni, S. G., Vijayanand, P. (2010). Effect of extraction conditions on the quality characteristics of pectin from passion fruit peel (Passiflora edulis f. flavicarpa L.). LWT - Food Sci. Technol., 43(7): 1026-1031.10.1016/j.lwt.2009.11.006 Search in Google Scholar

Kuo, H.W., Chang, C.C., Cheng, W. (2021). Synbiotic combination of prebiotic, cacao pod husk pectin and probiotic, Lactobacillus plantarum, improve the immunocompetence and growth of Litopenaeus vannamei. Fish Shellfish Immunol., 118: 333-342.10.1016/j.fsi.2021.09.023 Search in Google Scholar

Kuo, H.W., Chang, C.C., Cheng, W. (2022). Pectin from dry cacao pod husk mediates growth performance, immune resistance responses and carbohydrate metabolism of Litopenaeus vannamei through dietary administration. Aquaculture., 548: 737613.10.1016/j.aquaculture.2021.737613 Search in Google Scholar

Lan, Y., Wang, C., Zhang, C., Li, P., Zhang, J., Ji, H., Yu, H. (2022). Dietary sea buckthorn polysaccharide reduced lipid accumulation, alleviated inflammation and oxidative stress, and normalized imbalance of intestinal microbiota that was induced by high-fat diet in zebrafish Danio rerio. Fish Physiol. Biochem., 1-19.10.1007/s10695-022-01105-035879492 Search in Google Scholar

Lansky, E. P., Paavilainen, H. M., Pawlus, A. D., Newman, R. A. (2008). Ficus spp.(fig): Ethnobotany and potential as anticancer and anti-inflammatory J. Ethnopharmacol., 119(2): 195-213.10.1016/j.jep.2008.06.025 Search in Google Scholar

Lee, C.L., Chang, C.C., Kuo, H.W., Cheng, W. (2020). Pectin of cacao pod husk, an efficient immunostimulant for white shrimp, Litopenaeus vannamei. Fish Shellfish Immunol., 107: 357-366.10.1016/j.fsi.2020.10.026 Search in Google Scholar

Li, M.Y., Zhu, X.M., Niu, X.T., Chen, X.M., Tian, J.X., Kong, Y.D., Zhang, D.M., Zhao, L. Wang, G.Q. (2019). Effects of dietary Allium mongolicum Regel polysaccharide on growth, lipopolysaccharide-induced antioxidant responses and immune responses in Channa argus. Mol. Biol. Rep., 46(2): 2221-2230.10.1007/s11033-019-04677-y Search in Google Scholar

Li, Y., Ran, C., Wei, K., Xie, Y., Xie, M., Zhou, W., Yang, Y., Zhang, Z., Lv, H., Ma, X., Zhou, Z. (2021). The effect of Astragalus polysaccharide on growth, gut and liver health, and anti-viral immunity of zebrafish. Aquaculture., 540: 736677.10.1016/j.aquaculture.2021.736677 Search in Google Scholar

Lim, T. S., Na, K., Choi, E. M., Chung, J. Y., Hwang, J. K. (2004). Immunomodulating activities of polysaccharides isolated from Panax ginseng. J. Med. Food., 7(1): 1-6.10.1089/109662004322984626 Search in Google Scholar

Lin, S.M., Jiang, Y., Chen, Y.J., Luo, L., Doolgindachbaporn, S., Yuangsoi, B. (2017). Effects of Astragalus polysaccharides (APS) and chitooligosaccharides (COS) on growth, immune response and disease resistance of juvenile largemouth bass, Micropterus salmoides. Fish Shellfish Immunol., 70: 40-47.10.1016/j.fsi.2017.08.035 Search in Google Scholar

Liu, C., Ma, R., Wang, L., Zhu, R., Liu, H., Guo, Y., Gao, S. (2017a). Rehmanniae Radix in osteoporosis: A review of traditional Chinese medicinal uses, phytochemistry, pharmacokinetics and pharmacology. J. Ethnopharmacol., 198: 351-362.10.1016/j.jep.2017.01.02128111216 Search in Google Scholar

Liu, C., Zhao, C., Luo, X., Jiang, X., Gong, H., Huang, Z. (2017b). Effect of astragalus polysaccharides on nonspecific immunity of grass carp (Ctenopharyngodon idellus). J. Shanghai Ocean Univ., 26(4): 511-518. Search in Google Scholar

Liu, F., Geng, C., Qu, Y.K., Cheng, B.X., Zhang, Y., Wang, A.M., Zhang, J.H., Liu, B., Tian, H.Y., Yang, W.P., Yu, Y.B. (2020a). The feeding of dietary Codonopsis pilosula polysaccharide enhances the immune responses, the expression of immune-related genes and the growth performance of red swamp crayfish (Procambarus clarkii). Fish Shellfish Immunol., 103: 321-331.10.1016/j.fsi.2020.05.03432446966 Search in Google Scholar

Liu, J., Zhang, P., Wang, B., Lu, Y., Li, L., Li, Y., Liu, S. (2022). Evaluation of the effects of Astragalus polysaccharides as immunostimulants on the immune response of crucian carp and against SVCV in vitro and in vivo. Comp. Biochem. Physiol. Part - C: Toxicol. Pharmacol., 253: 109249.10.1016/j.cbpc.2021.109249 Search in Google Scholar

Liu, X.L., Xi, Q.Y., Yang, L., Li, H.Y., Jiang, Q.Y., Shu, G., Wang, S.B., Gao, P., Zhu, X.T., Zhang, Y.L. (2011). The effect of dietary Panax ginseng polysaccharide extract on the immune responses in white shrimp, Litopenaeus vannamei. Fish Shellfish Immunol., 30(2): 495-500.10.1016/j.fsi.2010.11.018 Search in Google Scholar

Liu, Y., Cao, L., Du, J., Jia, R., Wang, J., Xu, P., Yin, G. (2015). Protective effects of Lycium barbarum polysaccharides against carbon tetrachloride-induced hepatotoxicity in precision-cut liver slices in vitro and in vivo in common carp (Cyprinus carpio L.). Comp. Biochem. Physiol. Part - C: Toxicol. Pharmacol., 169: 65-72.10.1016/j.cbpc.2014.12.005 Search in Google Scholar

Liu, Y., Miao, Y., Xu, N., Ding, T., Cui, K., Chen, Q., Zhang, J., Fang, W., Mai, K., Ai, Q. (2020b). Effects of dietary Astragalus polysaccharides (APS) on survival, growth performance, activities of digestive enzyme, antioxidant responses and intestinal development of large yellow croaker (Larimichthys crocea) larvae. Aquaculture., 517: 734752.10.1016/j.aquaculture.2019.734752 Search in Google Scholar

Liu, Y.G., Hao, C., Shi, S., Dang, K., Huang, X., Zhao, Z., Shi, X. (2021). Transcriptome analysis of the immunomodulation by Arctium lappa L. polysaccharides in the Chinese mitten crab Eriocheir sinensis against Aeromonas hydrophila. Aquaculture., 534: 736255.10.1016/j.aquaculture.2020.736255 Search in Google Scholar

Lulijwa, R., Rupia, E.J., Alfaro, A.C. (2020). Antibiotic use in aquaculture, policies and regulation, health and environmental risks: a review of the top 15 major producers. Rev Aquac., 12(2): 640-663.10.1111/raq.12344 Search in Google Scholar

Lv, H., Hu, C., Xie, Z., Wang, P., Chen, X., Wen, C. (2020). Purification, characterization and anti-tumor activity of a pectic-type polysaccharide isolated from Ficus pandurata H. Int. J. Biol. Macromol., 153: 201-206.10.1016/j.ijbiomac.2020.02.244 Search in Google Scholar

Mao, F., Xiao, B., Jiang, Z., Zhao, J., Huang, X., Guo, J. (2011). Anticancer effect of Lycium barbarum polysaccharides on colon cancer cells involves G0/G1 phase arrest. Med. Oncol., 28(1): 121-126.10.1007/s12032-009-9415-5 Search in Google Scholar

Misra, N. N., Yadav, S. K. (2020). Extraction of pectin from black carrot pomace using intermittent microwave, ultrasound and conventional heating: Kinetics, characterization and process economics. Food Hydrocoll., 102: 105592.10.1016/j.foodhyd.2019.105592 Search in Google Scholar

Mohammadi, G., Hafezieh, M., Karimi, A.A., Azra, M.N., Van Doan, H., Tapingkae, W., Abdelrahman, H.A., Dawood, M.A. (2022a). The synergistic effects of plant polysaccharide and Pediococcus acidilactici as a synbiotic additive on growth, antioxidant status, immune response, and resistance of Nile tilapia (Oreochromis niloticus) against Aeromonas hydrophila. Fish Shellfish Immunol., 120: 304-313.10.1016/j.fsi.2021.11.02834838702 Search in Google Scholar

Mohammadi, G., Karimi, A.A., Hafezieh, M., Dawood, M.A., Abo-Al-Ela, H.G. (2022b). Pistachio hull polysaccharide protects Nile tilapia against LPS-induced excessive inflammatory responses and oxidative stress, possibly via TLR2 and Nrf2 signaling pathways. Fish Shellfish Immunol., 121: 276-284.10.1016/j.fsi.2021.12.04234968712 Search in Google Scholar

Mohammadi, G., Rafiee, G., El Basuini, M.F., Abdel-Latif, H.M., Dawood, M.A. (2020). The growth performance, antioxidant capacity, immunological responses, and the resistance against Aeromonas hydrophila in Nile tilapia (Oreochromis niloticus) fed Pistacia vera hulls derived polysaccharide. Fish Shellfish Immunol., 106: 36-43.10.1016/j.fsi.2020.07.064 Search in Google Scholar

Mohan, K., Karthick Rajan, D., Muralisankar, T., Ramu Ganesan, A., Marimuthu, K., Sathishkumar, P. (2022). The potential role of medicinal mushrooms as prebiotics in aquaculture: A review. Rev Aquac., 14(3): 1300-1332.10.1111/raq.12651 Search in Google Scholar

Mohan, K., Muralisankar, T., Uthayakumar, V., Chandirasekar, R., Rajan, D. K. (2019a). Dietary Ganoderma lucidum polysaccharides to enhance the growth, immune response and disease resistance of freshwater prawn Macrobrachium rosenbergii. Aquac. Rep., 14: 100203.10.1016/j.aqrep.2019.100203 Search in Google Scholar

Mohan, K., Padmanaban, A. M., Uthayakumar, V., Chandirasekar, R., Muralisankar, T., Santhanam, P. (2016). Effect of dietary Ganoderma lucidum polysaccharides on biological and physiological responses of the giant freshwater prawn Macrobrachium rosenbergii. Aquaculture., 464: 42-49.10.1016/j.aquaculture.2016.05.046 Search in Google Scholar

Mohan, K., Ravichandran, S., Muralisankar, T., Uthayakumar, V., Chandirasekar, R., Seedevi, P., Rajan, D. K. (2019b). Application of marine-derived polysaccharides as immunostimulants in aquaculture: A review of current knowledge and further perspectives. Fish Shellfish Immunol., 86: 1177-1193.10.1016/j.fsi.2018.12.07230599257 Search in Google Scholar

Mohan, K., Ravichandran, S., Muralisankar, T., Uthayakumar, V., Chandirasekar, R., Seedevi, P., Rajan, D. K. (2019c). Potential uses of fungal polysaccharides as immunostimulants in fish and shrimp aquaculture: a review. Aquaculture., 500: 250-263.10.1016/j.aquaculture.2018.10.023 Search in Google Scholar

National Pharmacopoeia Committee, (2015), Chinese Pharmacopoeia, China Medical Science and Technology Press, Beijing, 124-125. Search in Google Scholar

Özbek, H. N., Halahlih, F., Göğüş, F., Koçak Yanık, D., Azaizeh, H. (2020). Pistachio (Pistacia vera L.) Hull as a potential source of phenolic compounds: Evaluation of ethanol–water binary solvent extraction on antioxidant activity and phenolic content of pistachio hull extracts. Waste Biomass Valori., 11(5): 2101-2110.10.1007/s12649-018-0512-6 Search in Google Scholar

Pan, S., Jiang, L., Wu, S. (2018). Stimulating effects of polysaccharide from Angelica sinensis on the nonspecific immunity of white shrimps (Litopenaeus vannamei). Fish Shellfish Immunol., 74: 170-174.10.1016/j.fsi.2017.12.067 Search in Google Scholar

Pholdaeng, K., Pongsamart, S. (2010). Studies on the immunomodulatory effect of polysaccharide gel extracted from Durio zibethinus in Penaeus monodon shrimp against Vibrio harveyi and WSSV. Fish Shellfish Immunol., 28(4): 555-561.10.1016/j.fsi.2009.12.009 Search in Google Scholar

Pu, Y., Wu, S. (2022). The growth performance, body composition and nonspecific immunity of white shrimps (Litopenaeus vannamei) affected by dietary Astragalus membranaceus polysaccharide. Int. J. Biol. Macromol., 209: 162-165.10.1016/j.ijbiomac.2022.04.010 Search in Google Scholar

Qiao, Y., Liu, C., Guo, Y., Zhang, W., Guo, W., Oleksandr, K., Wang, Z. (2022). Polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis improve growth performance of broilers by enhancing intestinal health and modulating gut microbiota. Poult. Sci., 101(7): 101905.10.1016/j.psj.2022.101905 Search in Google Scholar

Qiu, S., Chen, J., Chen, X., Fan, Q., Zhang, C., Wang, D., Hu, Y. (2014). Optimization of selenylation conditions for Lycium barbarum polysaccharide based on antioxidant activity. Carbohydr. Polym., 103: 148-153.10.1016/j.carbpol.2013.12.032 Search in Google Scholar

Rajaei, A., Barzegar, M., Mobarez, A. M., Sahari, M. A., Esfahani, Z. H. (2010). Antioxidant, anti-microbial and antimutagenicity activities of pistachio (Pistachia vera) green hull extract. Food Chem. Toxicol., 48(1): 107-112.10.1016/j.fct.2009.09.023 Search in Google Scholar

Shalini, K.S., Yengkhom, O., Subramani, P.A., Michael, R.D. (2019). Polysaccharide fraction from the Indian mistletoe, Dendrophthoe falcata (Lf) Ettingsh enhances innate immunity and disease resistance in Oreochromis niloticus (Linn.). Fish Shellfish Immunol., 88: 407-414.10.1016/j.fsi.2019.03.008 Search in Google Scholar

Shi, F., Lu, Z., Yang, M., Li, F., Zhan, F., Zhao, L., Li, Y., Li, Q., Li, J., Li, J., Lin, L. (2021). Astragalus polysaccharides mediate the immune response and intestinal microbiota in grass carp (Ctenopharyngodon idellus). Aquaculture., 534: 736205.10.1016/j.aquaculture.2020.736205 Search in Google Scholar

Shi, S., Zhao, Y., Zhou, H., Zhang, Y., Jiang, X., Huang, K. (2008). Identification of antioxidants from Taraxacum mongolicum by high-performance liquid chromatography–diode array detection–radical-scavenging detection–electrospray ionization mass spectrometry and nuclear magnetic resonance experiments. J. Chromatogr. A., 1209(1-2): 145-152.10.1016/j.chroma.2008.09.004 Search in Google Scholar

Sinha, V. R., Kumria, R. (2001). Polysaccharides in colon-specific drug delivery. Int. J. Pharm., 224(1-2): 19-38.10.1016/S0378-5173(01)00720-7 Search in Google Scholar

Sista Kameshwar, A. K., Qin, W. (2018). Structural and functional properties of pectin and lignin–carbohydrate complexes de-esterases: a review. Bioresour. Bioprocess, 5(1): 1-16.10.1186/s40643-018-0230-8 Search in Google Scholar

Song, L., Guo, Z., Wang, A. (2018). Effects of Isatis root polysaccharide on non‐specific immune responses and nutritive indices in obscure pufferfish, Takifugu obscurus. Aquac. Res., 49(2): 603-613.10.1111/are.13472 Search in Google Scholar

Song, X., Feng, Z., Zhang, Y., Zhu, W. (2019). Regulation of dietary astragalus polysaccharide (APS) supplementation on the non-specific immune response and intestinal microbiota of sea cucumber Apostichopus japonicus. Fish Shellfish Immunol., 94: 517-524.10.1016/j.fsi.2019.09.049 Search in Google Scholar

Sun, Y., Jin, L., Wang, T., Xue, J., Liu, G., Li, X., You, J., Li, S., Xu, Y. (2008). Polysaccharides from Astragalus membranaceus promote phagocytosis and superoxide anion (O2−) production by coelomocytes from sea cucumber Apostichopus japonicus in vitro. Comp. Biochem. Physiol. Part - C: Toxicol. Pharmacol., 147(3): 293-298.10.1016/j.cbpc.2007.11.003 Search in Google Scholar

Sun, Y., Wang, X., Zhou, H., Mai, K., He, G. (2020). Dietary Astragalus polysaccharides ameliorates the growth performance, antioxidant capacity and immune responses in turbot (Scophthalmus maximus L.). Fish Shellfish Immunol., 99: 603-608.10.1016/j.fsi.2020.02.056 Search in Google Scholar

Sun, Y.X., Li, Y.J., Wen, Z.X., Li, X.J., Shi, L.X., Xu, Y.P., Wang, T.T. (2009). Effects of dietary supplemented with Astragalus membranaceus and Astragalus polysaccharides on growth performance in sea cucumber. Chin. Feed., 4: 31-46. Search in Google Scholar

Sun, Y.X., Xu, Y.P., Wang, T.T. (2009). Effects of Astragalus polysaccharide on gene expression of lysozyme in coelmocytes of sea cucumber Apostichopus japonicus. Fish Sci, 28(10): 572-574. Search in Google Scholar

Tadese, D. A., Song, C., Sun, C., Liu, B., Liu, B., Zhou, Q., Kevin, N. T. (2022). The role of currently used medicinal plants in aquaculture and their action mechanisms: A review. Rev Aquac., 14(2): 816-847.10.1111/raq.12626 Search in Google Scholar

Tan, L., Lin, H., Huang, Z., Zhou, C., Xun, P., Huang, Q., Yu, W., Huang, X., Yu, W. (2019). Effects of Lycium barbarum polysaccharide on growth performance, antioxidant capacity, serum immune and biochemical indexes of juvenile golden pompano (Trachinotus ovatus). Chin. J. Clin. Nutr., 31(1): 418-427. Search in Google Scholar

Tan, W., Yu, K. Q., Liu, Y. Y., Ouyang, M. Z., Yan, M. H., Luo, R., Zhao, X. S. (2012). Anti-fatigue activity of polysaccharides extract from Radix Rehmanniae Preparata. Int. J. Biol. Macromol., 50(1): 59-62.10.1016/j.ijbiomac.2011.09.019 Search in Google Scholar

Van Doan, H., Hoseinifar, S.H., Elumalai, P., Tongsiri, S., Chitmanat, C., Jaturasitha, S., Doolgindachbaporn, S. (2018). Effects of orange peels derived pectin on innate immune response, disease resistance and growth performance of Nile tilapia (Oreochromis niloticus) cultured under indoor biofloc system. Fish Shellfish Immunol., 80: 56-62.10.1016/j.fsi.2018.05.049 Search in Google Scholar

Van Doan, H., Hoseinifar, S.H., Esteban, M.Á., Dadar, M., Thu, T.T.N. (2019). Mushrooms, seaweed, and their derivatives as functional feed additives for aquaculture: an updated view. Stud. Nat. Prod. Chem., 62: 41-90.10.1016/B978-0-444-64185-4.00002-2 Search in Google Scholar

Van Doan, H., Hoseinifar, S.H., Naraballobh, W., Jaturasitha, S., Tongsiri, S., Chitmanat, C., Ringø, E. (2019). Dietary inclusion of Orange peels derived pectin and Lactobacillus plantarum for Nile tilapia (Oreochromis niloticus) cultured under indoor biofloc systems. Aquaculture., 508: 98-105.10.1016/j.aquaculture.2019.03.067 Search in Google Scholar

Van Hai, N. (2015). The use of medicinal plants as immunostimulants in aquaculture: A review. Aquaculture., 446: 88-96.10.1016/j.aquaculture.2015.03.014 Search in Google Scholar

Volpe, M.G., Santagata, G., Coccia, E., Di Stasio, M., Malinconico, M., Paolucci, M. (2015). Pectin‐based pellets for crayfish aquaculture: structural and functional characteristics and effects on redclaw Cherax quadricarinatus performances. Aquac. Nutr., 21(6): 814-823.10.1111/anu.12204 Search in Google Scholar

Wang, E., Chen, X., Liu, T., Wang, K. (2022). Effect of dietary Ficus carica polysaccharides on the growth performance, innate immune response and survival of crucian carp against Aeromonas hydrophila infection. Fish Shellfish Immunol., 120: 434-440.10.1016/j.fsi.2021.12.018 Search in Google Scholar

Wang, E., Chen, X., Wang, K., Wang, J., Chen, D., Geng, Y., Wei, X. (2016a). Plant polysaccharides used as immunostimulants enhance innate immune response and disease resistance against Aeromonas hydrophila infection in fish. Fish Shellfish Immunol., 59: 196-202.10.1016/j.fsi.2016.10.03927794459 Search in Google Scholar

Wang, K., Cao, P., Wang, H., Tang, Z., Wang, N., Wang, J., Zhang, Y. (2016b). Chronic administration of Angelica sinensis polysaccharide effectively improves fatty liver and glucose homeostasis in high-fat diet-fed mice. Sci. Rep., 6(1): 1-11.10.1038/srep26229487057227189109 Search in Google Scholar

Wang, K., Chen, X., Huang, J., He, M. (2011a). Effect of Ficus carica polysaccharides on non-specific immune response in Crucain carp. Acta Hydrobiol. Sin., 35(4): 630-637. Search in Google Scholar

Wang, Q.K., Chen, C.X., Guo, Y.J., Zhao, H.Y., Sun, J.F., Ma, S., Xing, K.Z. (2011b). Dietary polysaccharide from Angelica sinensis enhanced cellular defence responses and disease resistance of grouper Epinephelus malabaricus. Aquac Int., 19(5): 945-956.10.1007/s10499-010-9412-x Search in Google Scholar

Wang, Q.K., Xing, K.Z., Zhao, H.Y., Chen, C.X., Wu, Z.Y., Ma, S. (2012a). Dietary Angelica sinensis polysaccharide on innate immunity and disease resistance against Edwardsiella tarda of Epinephelus malabaricus. Periodi. J. Ocean Univ. China, 42(9): 15-21. Search in Google Scholar

Wang, Q.K., Zhao, H.Y., Lü, Z.M. (2012b). Effects of dietary Angelica sinensis Polysaccharide on nonspecific immunity of Epinephelus malabaricus. J. Anhui Agric. Univ, 39(22): 13857-13860. Search in Google Scholar

Wang, T., Sun, Y., Jin, L., Xu, Y., Wang, L., Ren, T., Wang, K. (2009). Enhancement of non-specific immune response in sea cucumber (Apostichopus japonicus) by Astragalus membranaceus and its polysaccharides. Fish Shellfish Immunol., 27(6): 757-762.10.1016/j.fsi.2009.09.002 Search in Google Scholar

Wang, Y., Kwak, M., Lee, P. C. W., Jin, J. O. (2018). Rehmannia glutinosa polysaccharide promoted activation of human dendritic cells. Int. J. Biol. Macromol., 116: 232-238.10.1016/j.ijbiomac.2018.04.144 Search in Google Scholar

Wei, G., Cai, S., Wu, Y., Ma, S., Huang, Y. (2020). Immune effect of Vibrio harveyi formalin-killed cells vaccine combined with chitosan oligosaccharide and astragalus polysaccharides in♀ Epinephelus fuscoguttatus×♂ Epinephelus lanceolatus. Fish Shellfish Immunol., 98: 186-192.10.1016/j.fsi.2020.01.015 Search in Google Scholar

Wu, C., Shan, J., Feng, J., Wang, J., Qin, C., Nie, G., Ding, C. (2019). Effects of dietary Radix Rehmanniae Preparata polysaccharides on the growth performance, immune response and disease resistance of Luciobarbus capito. Fish Shellfish Immunol., 89: 641-646.10.1016/j.fsi.2019.04.027 Search in Google Scholar

Wu, S. (2020). Dietary Astragalus membranaceus polysaccharide ameliorates the growth performance and innate immunity of juvenile crucian carp (Carassius auratus). Int. J. Biol. Macromol., 149: 877-881.10.1016/j.ijbiomac.2020.02.005 Search in Google Scholar

Xiang, X., Chen, J., Zhou, X., Wang, W. (2011). Effect of astragalus polysaccharides on growth, body composition and immune index in Schizothorax prenanti. Acta Hydrobiol. Sin., 35(2): 291-299.10.3724/SP.J.1035.2011.00291 Search in Google Scholar

Xie, J., Chen, R., Wang, Q., Mao, H. (2022). Exploration and validation of Taraxacum mongolicum anti-cancer effect. Comput. Biol. Med., 148: 105819. https://doi.org/10.1016/j.compbiomed.2022.105819.10.1016/j.compbiomed.2022.10581935810695 Search in Google Scholar

Xu, L., Zhang, W., Zeng, L., Jin, J. O. (2017). Rehmannia glutinosa polysaccharide induced an anti-cancer effect by activating natural killer cells. Int. J. Biol. Macromol., 105: 680-685.10.1016/j.ijbiomac.2017.07.090 Search in Google Scholar

Yang, T., Jia, M., Meng, J., Wu, H., Mei, Q. (2006). Immunomodulatory activity of polysaccharide isolated from Angelica sinensis. Int. J. Biol. Macromol., 39(4-5): 179-184.10.1016/j.ijbiomac.2006.02.013 Search in Google Scholar

Yang, T., Jia, M., Zhou, S., Pan, F., Mei, Q. (2012). Antivirus and immune enhancement activities of sulfated polysaccharide from Angelica sinensis. Int. J. Biol. Macromol., 50(3): 768-772.10.1016/j.ijbiomac.2011.11.027 Search in Google Scholar

Yang, X. M., Yu, W., Ou, Z. P., Ma, H. L., Liu, W. M., Ji, X. L. (2009). Antioxidant and immunity activity of water extract and crude polysaccharide from Ficus carica L. fruit. Plant Foods Hum. Nutr., 64(2): 167-173.10.1007/s11130-009-0120-5 Search in Google Scholar

Yang, X., Guo, J.L., Ye, J.Y., Zhang, Y.X., Wang, W. (2015). The effects of Ficus carica polysaccharide on immune response and expression of some immune-related genes in grass carp, Ctenopharyngodon idella. Fish Shellfish Immunol., 42(1): 132-137.10.1016/j.fsi.2014.10.037 Search in Google Scholar

Yi, R., Liu, X. M., Dong, Q. (2013). A study of Lycium barbarum polysaccharides (LBP) extraction technology and its anti-aging effect. Afr. J. Tradit. Complement. Altern. Med., 10(4): 171-174.10.4314/ajtcam.v10i4.27 Search in Google Scholar

Yu, W., Yang, Y., Zhou, Q., Huang, X., Huang, Z., Li, T., Wu, Q., Zhou, C., Ma, Z., Lin, H. (2022a). Effects of dietary Astragalus polysaccharides on growth, health and resistance to Vibrio harveyi of Lates calcarifer. Int. J. Biol. Macromol., 207: 850-858.10.1016/j.ijbiomac.2022.03.17635364191 Search in Google Scholar

Yu, Z., Zhao, L., Zhao, J.L., Xu, W., Guo, Z., Zhang, A.Z., Li, M.Y. (2022b). Dietary Taraxacum mongolicum polysaccharide ameliorates the growth, immune response, and antioxidant status in association with NF-κB, Nrf2 and TOR in Jian carp (Cyprinus carpio var. Jian). Aquaculture., 547: 737522.10.1016/j.aquaculture.2021.737522 Search in Google Scholar

Yuan, C., Pan, X., Gong, Y., Xia, A., Wu, G., Tang, J., Han, X. (2008). Effects of Astragalus polysaccharides (APS) on the expression of immune response genes in head kidney, gill and spleen of the common carp, Cyprinus carpio L. Int. Immunopharmacol., 8(1): 51-58.10.1016/j.intimp.2007.10.009 Search in Google Scholar

Yuvaraj, N., Arul, V. (2017). Immunomodulatory effects of seagrass Halophila ovalis polysaccharide mixed feed in adult black tiger shrimp Penaeus monodon and its protective efficacy against white spot syndrome virus infection. 16(3): 20.1001.1.15622916.2017.16.3.11.6. Search in Google Scholar

Zahran, E., Risha, E., AbdelHamid, F., Mahgoub, H. A., Ibrahim, T. (2014). Effects of dietary Astragalus polysaccharides (APS) on growth performance, immunological parameters, digestive enzymes, and intestinal morphology of Nile tilapia (Oreochromis niloticus). Fish Shellfish Immunol., 38(1): 149-157.10.1016/j.fsi.2014.03.002 Search in Google Scholar

Zhai, Q., Li, J., Feng, Y., Ge, Q. (2019). Evaluation of combination effects of Astragalus polysaccharides and florfenicol against acute hepatopancreatic necrosis disease-causing strain of Vibrio parahaemolyticus in Litopenaeus vannamei. Fish Shellfish Immunol., 86: 374-383.10.1016/j.fsi.2018.11.065 Search in Google Scholar

Zhang, W., Zhang, M., Cheng, A., Hao, E., Huang, X., Chen, X. (2020a). Immunomodulatory and antioxidant effects of Astragalus polysaccharide liposome in large yellow croaker (Larimichthys crocea). Fish Shellfish Immunol., 100: 126-136.10.1016/j.fsi.2020.03.00432142872 Search in Google Scholar

Zhang, X., Huang, K., Zhong, H., Ma, Y., Guo, Z., Tang, Z., Liang, J., Luo, Y., Su, Z., Wang, L. (2020b). Effects of Lycium barbarum polysaccharides on immunological parameters, apoptosis, and growth performance of Nile tilapia (Oreochromis niloticus). Fish Shellfish Immunol., 97: 509-514.10.1016/j.fsi.2019.12.06831877360 Search in Google Scholar

Zhang, X., Xiao, J., Guo, Z., Zhong, H., Luo, Y., Wang, J., Tang, Z., Huang, T., Li, M., Zhu, J., Ao, Q. (2022). Transcriptomics integrated with metabolomics reveals the effect of Lycium barbarum polysaccharide on apoptosis in Nile tilapia (Oreochromis niloticus). Genomics., 114(1): 229-240.10.1016/j.ygeno.2021.12.009 Search in Google Scholar

Zhao, J. L., Zhang, M., Zhou, H. L. (2019). Microwave-assisted extraction, purification, partial characterization, and bioactivity of polysaccharides from Panax ginseng. Molecules., 24(8): 1605.10.3390/molecules24081605 Search in Google Scholar

Zhao, L., Tan, S., Zhang, H., Liu, P., Tan, Y. Z., Li, J. C., Shen, X. F. (2018). Astragalus polysaccharides exerts anti-infective activity by inducing human cathelicidin antimicrobial peptide LL-37 in respiratory epithelial cells. Phytother. Res., 32(8):1521-1529.10.1002/ptr.6080 Search in Google Scholar

Zhao, L., Zhao, J.L., Bai, Z., Du, J., Shi, Y., Wang, Y., Wang, Y., Liu, Y., Yu, Z., Li, M.Y. (2022). Polysaccharide from dandelion enriched nutritional composition, antioxidant capacity, and inhibited bioaccumulation and inflammation in Channa asiatica under hexavalent chromium exposure. Int. J. Biol. Macromol., 201: 557-568.10.1016/j.ijbiomac.2021.12.117 Search in Google Scholar

Zhou, L., Liu, Z., Wang, Z., Yu, S., Long, T., Zhou, X., Bao, Y. (2017). Astragalus polysaccharides exerts immunomodulatory effects via TLR4-mediated MyD88-dependent signaling pathway in vitro and in vivo. Sci. Rep., 7(1): 1-13.10.1038/srep44822 Search in Google Scholar

Zhou, W. J., Wang, S., Hu, Z., Zhou, Z. Y., Song, C. J. (2015). Angelica sinensis polysaccharides promotes apoptosis in human breast cancer cells via CREB-regulated caspase-3 activation. Biochem. Biophys. Res. Commun., 467(3): 562-569.10.1016/j.bbrc.2015.09.145 Search in Google Scholar

Zhu, W., Zhang, Y., Zhang, J., Yuan, G., Liu, X., Ai, T., Su, J. (2019). Astragalus polysaccharides, chitosan and poly (I: C) obviously enhance inactivated Edwardsiella ictaluri vaccine potency in yellow catfish Pelteobagrus fulvidraco. Fish Shellfish Immunol., 87: 379-385.10.1016/j.fsi.2019.01.033 Search in Google Scholar

Zhu, X.M., Liu, X.Y., Xia, C.G., Li, M.Y., Niu, X.T., Wang, G.Q., Zhang, D.M. (2021). Effects of dietary Astragalus Propinquus Schischkin polysaccharides on growth performance, immunological parameters, antioxidants responses and inflammation-related gene expression in Channa argus. Comp. Biochem. Physiol. C Toxicol. Pharmacol., 249: 109121.10.1016/j.cbpc.2021.109121 Search in Google Scholar

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