Effects of Sex Steroid Receptor Agonists and Antagonists on the Expression of the FOXL2 Transcription Factor and its Target Genes AMH and CYP19A1 in the Neonatal Porcine Ovary
Online veröffentlicht: 04. Feb. 2022
Seitenbereich: 141 - 153
Eingereicht: 02. Feb. 2021
Akzeptiert: 14. Mai 2021
DOI: https://doi.org/10.2478/aoas-2021-0037
Schlüsselwörter
© 2022 Patrycja Witek et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
Recently, we have demonstrated that neonatal exposure to androgen and estrogen agonists or antagonists influenced the number of ovarian follicles in piglets. Since the FOXL2 transcription factor is required for proper ovarian follicle formation and activation, the objective of the study was to examine effects of exposure of the neonatal porcine ovary to testosterone propionate (TP; an androgen), flutamide (FLU; an antiandrogen), 4