Assessment of a score’s performance in predicting positive culture studies in preterm neonates with clinical suspicion of sepsis
Ricardo Barreto Mota
Neonatal Intensive Care Unit, Centro Hospitalar e Universitário São JoãoPorto, Portugal
Orcid profileSearch for this author on
, Paulo Soares
Neonatal Intensive Care Unit, Centro Hospitalar e Universitário São JoãoPorto, Portugal
Orcid profileSearch for this author on
and Hercília Guimarães
- Neonatal Intensive Care Unit, Centro Hospitalar e Universitário São JoãoPorto, Portugal
- Faculty of Medicine of University of PortoPorto, Portugal
Orcid profileSearch for this author on
Apr 01, 2022
About this article
Article Category: Short communication
Published Online: Apr 01, 2022
Page range: 119 - 122
Received: Aug 14, 2021
Accepted: Oct 08, 2021
DOI: https://doi.org/10.34763/jmotherandchild.20212502.d-21-00019
Keywords
© 2021 Ricardo Barreto Mota et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
Score comparison between groups and Receiver Operator Characteristics (ROC) Curve results for significant parameters_ *Mann-Whitney U test; †χ2 test; ‡Fisher exact test; GA – gestational age, WBC – white blood count, PLT – platelet, CRP – C-reactive protein, AUC – area under the curve
| Parameters | Cultural Study (CS) | ROC curve | |||
|---|---|---|---|---|---|
| Negative (n=15) | Positive (n=18) | AUC (95% CI) | |||
| GA, median weeks, [inter-quartile range (IQR)] Birthweight, median grams [IQR] | 27.6 [26.6-29.4] 1030 [855-1400] | 28.2 [27.6-30.3] 1043 [940-1360] | - | - | - |
| Median 1st Minute Apgar Score | 6 | 7 | |||
| Median 5th Minute Apgar Score | 7 | 8 | |||
| Median 10th Minute Apgar Score | 8 | 8 | |||
| Post Menstrual Age at Sepsis Suspicion, Median weeks [IQR] | 29.3 [28.1-31.6] | 30.6 [29.4-32.1] | |||
| WBC count at suspicion, median x 10^9/L [IQR] | 21.3 [10.5-23.9] | 16.3 [9-25.1] | 0.391* | - | - |
| PLT count at suspicion, median x 10^9/L [IQR] | 420 [301-549] | 230 [170-325] | 0.024* | 0.767 (0.60-0.94) | 0.011 |
| CRP at suspicion, median mg/L [IQR] | 9.5 [2.2-18.4] | 17.5 [4.9-39.9] | 0.215* | - | - |
| WBC at 2nd timing, median x 10^9/L [IQR] | 17.1 [8.8-23-3] | 14 [10.2-20.3] | 0.862* | - | - |
| PTL at 2nd timing, median x 10^9/L [IQR] | 395 [222-529] | 153 [99-288] | 0.02* | 0.892 (0.78-1) | <0.001 |
| CPR at 2nd timing, median mg/L [IQR] | 5.8 [1.1-14.5] | 40.8 [14.9-82.4] | 0.009* | 0.807 (0.64-0.98) | 0.005 |
| Score at suspicion, median | 2.00 | 3.00 | 1.000* | - | - |
| Score at second timing, median | 2.00 | 5.00 | .021* | 0.798 (0.63-0.97) | 0.007 |
| Higher score in the second measure, n (%) | 3 (21.4%) | 10 (66.7%) | 0.014† | - | - |
| Lower PLT count in the second measure, n (%) | 9 (60%) | 13 (81.3%) | 0.252† | - | - |
| Higher CRP value in the second measure, n (%) | 4 (28.6%) | 12 (75%) | 0.011† | - | - |
| Intubation between both measures, n (%) | 0 | 7 (41.2%) | 0.008‡ | - | - |
| Respiratory score at suspicion, median | 1.00 | 1.00 | 0.798* | - | - |
| Analytical score at suspicion, median | 1.00 | 1.00 | 0.266* | - | - |
| Respiratory score at 2nd timing, median | 1.00 | 2.00 | 0.296* | - | - |
| Analytical score at 2nd timing, median | 1.00 | 3.00 | 0.001* | 0.800 (0.62-0.98) | .006 |