Assessment of a score’s performance in predicting positive culture studies in preterm neonates with clinical suspicion of sepsis
, y | 01 abr 2022
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Article Category: Short communication
Publicado en línea: 01 abr 2022
Páginas: 119 - 122
Recibido: 14 ago 2021
Aceptado: 08 oct 2021
DOI: https://doi.org/10.34763/jmotherandchild.20212502.d-21-00019
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© 2021 Ricardo Barreto Mota et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
Score comparison between groups and Receiver Operator Characteristics (ROC) Curve results for significant parameters. *Mann-Whitney U test; †χ2 test; ‡Fisher exact test; GA – gestational age, WBC – white blood count, PLT – platelet, CRP – C-reactive protein, AUC – area under the curve
| Parameters | Cultural Study (CS) | ROC curve | |||
|---|---|---|---|---|---|
| Negative (n=15) | Positive (n=18) | AUC (95% CI) | |||
| GA, median weeks, [inter-quartile range (IQR)] Birthweight, median grams [IQR] | 27.6 [26.6-29.4] 1030 [855-1400] | 28.2 [27.6-30.3] 1043 [940-1360] | - | - | - |
| Median 1st Minute Apgar Score | 6 | 7 | |||
| Median 5th Minute Apgar Score | 7 | 8 | |||
| Median 10th Minute Apgar Score | 8 | 8 | |||
| Post Menstrual Age at Sepsis Suspicion, Median weeks [IQR] | 29.3 [28.1-31.6] | 30.6 [29.4-32.1] | |||
| WBC count at suspicion, median x 10^9/L [IQR] | 21.3 [10.5-23.9] | 16.3 [9-25.1] | 0.391* | - | - |
| PLT count at suspicion, median x 10^9/L [IQR] | 420 [301-549] | 230 [170-325] | 0.024* | 0.767 (0.60-0.94) | 0.011 |
| CRP at suspicion, median mg/L [IQR] | 9.5 [2.2-18.4] | 17.5 [4.9-39.9] | 0.215* | - | - |
| WBC at 2nd timing, median x 10^9/L [IQR] | 17.1 [8.8-23-3] | 14 [10.2-20.3] | 0.862* | - | - |
| PTL at 2nd timing, median x 10^9/L [IQR] | 395 [222-529] | 153 [99-288] | 0.02* | 0.892 (0.78-1) | <0.001 |
| CPR at 2nd timing, median mg/L [IQR] | 5.8 [1.1-14.5] | 40.8 [14.9-82.4] | 0.009* | 0.807 (0.64-0.98) | 0.005 |
| Score at suspicion, median | 2.00 | 3.00 | 1.000* | - | - |
| Score at second timing, median | 2.00 | 5.00 | .021* | 0.798 (0.63-0.97) | 0.007 |
| Higher score in the second measure, n (%) | 3 (21.4%) | 10 (66.7%) | 0.014† | - | - |
| Lower PLT count in the second measure, n (%) | 9 (60%) | 13 (81.3%) | 0.252† | - | - |
| Higher CRP value in the second measure, n (%) | 4 (28.6%) | 12 (75%) | 0.011† | - | - |
| Intubation between both measures, n (%) | 0 | 7 (41.2%) | 0.008‡ | - | - |
| Respiratory score at suspicion, median | 1.00 | 1.00 | 0.798* | - | - |
| Analytical score at suspicion, median | 1.00 | 1.00 | 0.266* | - | - |
| Respiratory score at 2nd timing, median | 1.00 | 2.00 | 0.296* | - | - |
| Analytical score at 2nd timing, median | 1.00 | 3.00 | 0.001* | 0.800 (0.62-0.98) | .006 |