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Journal Details
License
Format
Journal
First Published
19 Jun 2009
Publication timeframe
4 times per year
Languages
English
access type Open Access

Review of skin irritation/corrosion hazards on the basis of human data: a regulatory perspective

Journal Details
License
Format
Journal
First Published
19 Jun 2009
Publication timeframe
4 times per year
Languages
English

Regulatory classification of skin irritation has historically been based on rabbit data, however current toxicology processes are transitioning to in vitro alternatives. The in vitro assays have to provide sufficient level of sensitivity as well as specificity to be accepted as replacement methods for the existing in vivo assays. This is usually achieved by comparing the in vitro results to classifications obtained in animals. Significant drawback of this approach is that neither in vivo nor in vitro methods are calibrated against human hazard data and results obtained in these assays may not correspond to situation in human.

Keywords

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