Value of serum NT-IGFBP-4 for non-invasive risk stratification of coronary heart disease and predictive efficiency for complexity of coronary artery lesions
Published Online: Aug 06, 2025
Page range: 151 - 156
Received: Feb 20, 2025
Accepted: May 12, 2025
DOI: https://doi.org/10.2478/rrlm-2025-0016
Keywords
© 2025 Huiqing Lv et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
Background
We aimed to explore the value of serum N-terminal insulin-like growth factor-binding protein 4 (NT-IGFBP-4) in the non-invasive risk stratification of coronary heart disease and its predictive efficiency for the complexity of coronary artery lesions [assessed by Synergy between PCI with TAXUS and Cardiac Surgery (SYNTAX) and SYNTAX II scores].
Methods
Subjects (180 in total) were recruited from patients treated between September 2023 and September 2024. Serum NT-IGFBP-4 level was measured. SYNTAX and SYNTAX II scores were assessed.
Results
The serum NT-IGFBP-4 level, SYNTAX score, and SYNTAX II score of the high-risk group were significantly higher than those of medium- and low-risk groups (
Conclusions
Serum NT-IGFBP-4 reflects the pathophysiological state of coronary heart disease when combined with the SYNTAX II scoring system. It shows a significant positive correlation with the risk of coronary heart disease and can independently predict this risk.