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Investigation of the association of the RAN (rs14035) and XPO5 (rs11077) polymorphisms with venous thromboembolism

Khloud M. Alquraan

Khloud M. Alquraan

Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and TechnologyIrbid, Jordan
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Alquraan, Khloud M.
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Omar F. Khabour

Omar F. Khabour

Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and TechnologyIrbid, Jordan
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Khabour, Omar F.
  
Jun 13, 2023
Investigation of the association of the RAN (rs14035) and XPO5 (rs11077) polymorphisms with venous thromboembolism's Cover Image
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Published Online: Jun 13, 2023
Page range: 154 - 162
Received: May 06, 2023
DOI: https://doi.org/10.2478/rjim-2023-0014
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© 2023 Khloud M. Alquraan et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Introduction

Venous thromboembolism (VTE) is the third most common hemostatic disease worldwide. Studies have reported a role for microRNA (miRNA) in the homeostasis and development of VTE. The ras-related nuclear protein (RAN) and exportin 5 (XPO5) genes are involved in miRNA biogenesis, as both regulate the transport of pre-miRNA from the nucleus to the cytoplasm. Therefore, the aim of the current study is to examine the association between RAN (rs14035) and XPO5 (rs11077) single nucleotide polymorphisms (SNPs) and VTE.

Methods

The study sample consisted of 300 subjects (150 patients and 150 age and sex matched controls). The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and tetra‐primer amplification refractory mutation system (T-ARMS) techniques were used to genotype rs14035 and rs11077, respectively.

Results

The results showed that there was a significant association between the XPO5 rs11077 and the risk of VTE (P < 0.05). Subjects with AC (OR: 2.08, CI:1.26–3.44) and CC (OR: 1.77, CI: 0.88–3.55) genotypes were at increased risk of the developing VTE. Regarding RAN gene, no association was found between rs14035 and VTE (P > 0.05). In addition, no associations were found between XPO5 rs11077 and RAN rs14035 genotypes with blood cell parameters (P > 0.05). As for the demographic characteristics, the results indicated a strong association between family history and body mass index (BMI) with the risk of VTE (P < 0.01).

Conclusion

The XPO5 rs11077, BMI and family history might contribute to the development of VTE in Jordan.
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English
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Journal Subjects:
Medicine, Clinical Medicine, Internal Medicine, Internal Medicine, other, Cardiology, Gastroenterology, Rheumatology
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