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Effectiveness of tramadol or topic lidocaine compared to epidural or opioid analgesia on postoperative analgesia in laparoscopic colorectal tumor resection

Alenka Spindler-Vesel

Alenka Spindler-Vesel

  • Clinical Department of Anaesthesiology and Intensive Care Medicine, University Medical Centre LjubljanaLjubljana, Slovenia
  • Medical Faculty, University of LjubljanaLjubljana, Slovenia
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Spindler-Vesel, Alenka
, 
Matej Jenko

Matej Jenko

  • Clinical Department of Anaesthesiology and Intensive Care Medicine, University Medical Centre LjubljanaLjubljana, Slovenia
  • Medical Faculty, University of LjubljanaLjubljana, Slovenia
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Jenko, Matej
, 
Ajsa Repar

Ajsa Repar

Department of Anaesthesiology and Intensive Care, Institute of Oncology LjubljanaLjubljana, Slovenia
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Repar, Ajsa
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Iztok Potocnik

Iztok Potocnik

  • Medical Faculty, University of LjubljanaLjubljana, Slovenia
  • Department of Anaesthesiology and Intensive Care, Institute of Oncology LjubljanaLjubljana, Slovenia
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Potocnik, Iztok
 and 
Jasmina Markovic-Bozic

Jasmina Markovic-Bozic

  • Clinical Department of Anaesthesiology and Intensive Care Medicine, University Medical Centre LjubljanaLjubljana, Slovenia
  • Medical Faculty, University of LjubljanaLjubljana, Slovenia
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Markovic-Bozic, Jasmina
  
Jan 04, 2025
Effectiveness of tramadol or topic lidocaine compared to epidural or opioid analgesia on postoperative analgesia in laparoscopic colorectal tumor resection's Cover Image
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Article Category: research article
Published Online: Jan 04, 2025
Page range: 132 - 138
Received: Jun 18, 2024
Accepted: Oct 24, 2024
DOI: https://doi.org/10.2478/raon-2025-0003
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© 2025 Alenka Spindler-Vesel et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.

FIGURE 1.

Consort chart of the study. Thet diagram shows the flow of participants through each stage of a randomized trial. PCA = patient-controlled analgesia; PCEA = patient-controlled epidural analgesia
Consort chart of the study. Thet diagram shows the flow of participants through each stage of a randomized trial. PCA = patient-controlled analgesia; PCEA = patient-controlled epidural analgesia

FIGURE 2.

Piritramide consumption on day of surgery (day 0).
Piritramide consumption on day of surgery (day 0).

FIGURE 3.

Piritramide consumption on first postoperative day (day 1). PCA = patient-controlled analgesia; PCEA = patient-controlled epidural analgesia
Piritramide consumption on first postoperative day (day 1). PCA = patient-controlled analgesia; PCEA = patient-controlled epidural analgesia

FIGURE 4.

Piritramide consumption on second postoperative day (day 2). PCA = patient-controlled analgesia; PCEA = patient-controlled epidural analgesia
Piritramide consumption on second postoperative day (day 2). PCA = patient-controlled analgesia; PCEA = patient-controlled epidural analgesia

Comparison of piritramide consumption between the group pairs

Comparison P value (day 0) P value (day 1) P value (day 2)
PCA PCEA 0.938 < 0.001 < 0.001
PCA tramadol-metamizole 0.083 < 0.001 < 0.001
PCA PCA + lidocaine 0.995 0.003 0.026
PCEA tramadol-metamizole 0.008 0.352 0.038
PCEA PCA + lidocaine 0.862 < 0.001 < 0.001
PCA + lidocaine tramadol-metamizole 0.030 < 0.001 < 0.001

The scores from Pain Detect and DN4 (Douleur Neuropathique 4) questionnaires in the study groups

Group (No. of answers) Pain score (mean ± SD) DN4 (mean ± SD)
PCA (12) 0 0
Tramadol and metamizole (12) 1.2 ±2.1 0.2 ± 0.4
PCEA (15) 0.1 ± 0.5 0.1 ± 0.4
Lidocaine (17) 0.06 ± 0.2 0

General patients’ and procedure characteristics

Group 1 (PCA) Group 2 (tramadol-metamizole) Group 3 (PCEA) Group 4 (PCA and lidocaine) p
Age (years) 59 65 60 59 0,394
Weight (kg) 76 75 79 76 0,833
Wound length (cm) 6,55 7,17 7,45 7,90 0,286
Duration of surgery (min) 139 133 117 112 0,024
Duration of hospitalization (days) 8 9 8 10 0,380
Day of first defecation 4 4 5 4 0,571
Language:
English
Publication timeframe:
4 times per year
Journal Subjects:
Medicine, Clinical Medicine, Internal Medicine, Haematology, Oncology, Radiology
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