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Effectiveness of tramadol or topic lidocaine compared to epidural or opioid analgesia on postoperative analgesia in laparoscopic colorectal tumor resection

Alenka Spindler-Vesel

Alenka Spindler-Vesel

  • Clinical Department of Anaesthesiology and Intensive Care Medicine, University Medical Centre LjubljanaLjubljana, Slovenia
  • Medical Faculty, University of LjubljanaLjubljana, Slovenia
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Spindler-Vesel, Alenka
, 
Matej Jenko

Matej Jenko

  • Clinical Department of Anaesthesiology and Intensive Care Medicine, University Medical Centre LjubljanaLjubljana, Slovenia
  • Medical Faculty, University of LjubljanaLjubljana, Slovenia
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Jenko, Matej
, 
Ajsa Repar

Ajsa Repar

Department of Anaesthesiology and Intensive Care, Institute of Oncology LjubljanaLjubljana, Slovenia
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Repar, Ajsa
, 
Iztok Potocnik

Iztok Potocnik

  • Medical Faculty, University of LjubljanaLjubljana, Slovenia
  • Department of Anaesthesiology and Intensive Care, Institute of Oncology LjubljanaLjubljana, Slovenia
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Potocnik, Iztok
 und 
Jasmina Markovic-Bozic

Jasmina Markovic-Bozic

  • Clinical Department of Anaesthesiology and Intensive Care Medicine, University Medical Centre LjubljanaLjubljana, Slovenia
  • Medical Faculty, University of LjubljanaLjubljana, Slovenia
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Markovic-Bozic, Jasmina
  
04. Jan. 2025
Effectiveness of tramadol or topic lidocaine compared to epidural or opioid analgesia on postoperative analgesia in laparoscopic colorectal tumor resection's Cover Image
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Artikel-Kategorie: research article
Online veröffentlicht: 04. Jan. 2025
Seitenbereich: 132 - 138
Eingereicht: 18. Juni 2024
Akzeptiert: 24. Okt. 2024
DOI: https://doi.org/10.2478/raon-2025-0003
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© 2025 Alenka Spindler-Vesel et al., published by Sciendo
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FIGURE 1.

Consort chart of the study. Thet diagram shows the flow of participants through each stage of a randomized trial. PCA = patient-controlled analgesia; PCEA = patient-controlled epidural analgesia
Consort chart of the study. Thet diagram shows the flow of participants through each stage of a randomized trial. PCA = patient-controlled analgesia; PCEA = patient-controlled epidural analgesia

FIGURE 2.

Piritramide consumption on day of surgery (day 0).
Piritramide consumption on day of surgery (day 0).

FIGURE 3.

Piritramide consumption on first postoperative day (day 1). PCA = patient-controlled analgesia; PCEA = patient-controlled epidural analgesia
Piritramide consumption on first postoperative day (day 1). PCA = patient-controlled analgesia; PCEA = patient-controlled epidural analgesia

FIGURE 4.

Piritramide consumption on second postoperative day (day 2). PCA = patient-controlled analgesia; PCEA = patient-controlled epidural analgesia
Piritramide consumption on second postoperative day (day 2). PCA = patient-controlled analgesia; PCEA = patient-controlled epidural analgesia

Comparison of piritramide consumption between the group pairs

Comparison P value (day 0) P value (day 1) P value (day 2)
PCA PCEA 0.938 < 0.001 < 0.001
PCA tramadol-metamizole 0.083 < 0.001 < 0.001
PCA PCA + lidocaine 0.995 0.003 0.026
PCEA tramadol-metamizole 0.008 0.352 0.038
PCEA PCA + lidocaine 0.862 < 0.001 < 0.001
PCA + lidocaine tramadol-metamizole 0.030 < 0.001 < 0.001

The scores from Pain Detect and DN4 (Douleur Neuropathique 4) questionnaires in the study groups

Group (No. of answers) Pain score (mean ± SD) DN4 (mean ± SD)
PCA (12) 0 0
Tramadol and metamizole (12) 1.2 ±2.1 0.2 ± 0.4
PCEA (15) 0.1 ± 0.5 0.1 ± 0.4
Lidocaine (17) 0.06 ± 0.2 0

General patients’ and procedure characteristics

Group 1 (PCA) Group 2 (tramadol-metamizole) Group 3 (PCEA) Group 4 (PCA and lidocaine) p
Age (years) 59 65 60 59 0,394
Weight (kg) 76 75 79 76 0,833
Wound length (cm) 6,55 7,17 7,45 7,90 0,286
Duration of surgery (min) 139 133 117 112 0,024
Duration of hospitalization (days) 8 9 8 10 0,380
Day of first defecation 4 4 5 4 0,571
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