<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Background</h3>
<p>This study aimed to evaluate the multi-phase CT findings of central and peripheral pulmonary sclerosing pneumocytomas (PSPs) and compared them with Ki-67 to reveal their neoplastic nature.</p>
</sec>
<sec><h3>Patients and methods</h3>
<p>Multi-phase CT and clinical data of 33 PSPs (15 central PSPs and 18 peripheral PSPs) were retrospectively analyzed and compared their multi-phase CT features and Ki-67 levels.</p>
</sec>
<sec><h3>Results</h3>
<p>For quantitative indicators, central PSPs were larger than peripheral PSPs (10.39 ± 3.25 cm<sup>3</sup> <italic>vs.</italic> 4.65 ± 2.61 cm<sup>3</sup>, P = 0.013), and tumor size was negatively correlated with acceleration index (r = −0.845, P &lt; 0.001). The peak enhancement of central PSPs appeared in the delayed phase, with a longer time to peak enhancement (TTP, 100.81 ± 19.01 s), lower acceleration index (0.63 ± 0.17), progressive enhancement, and higher Ki-67 level. The peak enhancement of peripheral PSPs appeared in the venous phase, with the shorter TTP (62.67 ± 20.96 s, P &lt; 0.001), higher acceleration index (0.99 ± 0.25, P &lt; 0.001), enhancement washout, and lower Ki-67 level. For qualitative indicators, the overlying vessel sign (86.67% <italic>vs.</italic> 44.44%, P = 0.027), prominent pulmonary artery sign (73.33% <italic>vs.</italic> 27.78%, P = 0.015), and obstructive inflammation/atelectasis (26.67% <italic>vs.</italic> 0%, P = 0.033) were more common in central PSPs, while peripheral PSPs were more common with halo sign (38.89% <italic>vs.</italic> 6.67%, P = 0.046).</p>
</sec>
<sec><h3>Conclusions</h3>
<p>The location of PSP is a possible contributing factor to its diverse imaging-pathological findings. The tumor size, multi-phase enhancement, qualitative signs, and Ki-67 were different between central and peripheral PSPs. Combined tumor size, multi-phase findings, and Ki-67 level are helpful to reveal the nature of the borderline tumor.</p>
</sec>
</abstract>

Background
This study aimed to evaluate the multi-phase CT findings of central and peripheral pulmonary sclerosing pneumocytomas (PSPs) and compared them with Ki-67 to reveal their neoplastic nature.

Patients and methods
Multi-phase CT and clinical data of 33 PSPs (15 central PSPs and 18 peripheral PSPs) were retrospectively analyzed and compared their multi-phase CT features and Ki-67 levels.

Results
For quantitative indicators, central PSPs were larger than peripheral PSPs (10.39 ± 3.25 cm3 vs. 4.65 ± 2.61 cm3, P = 0.013), and tumor size was negatively correlated with acceleration index (r = −0.845, P < 0.001). The peak enhancement of central PSPs appeared in the delayed phase, with a longer time to peak enhancement (TTP, 100.81 ± 19.01 s), lower acceleration index (0.63 ± 0.17), progressive enhancement, and higher Ki-67 level. The peak enhancement of peripheral PSPs appeared in the venous phase, with the shorter TTP (62.67 ± 20.96 s, P < 0.001), higher acceleration index (0.99 ± 0.25, P < 0.001), enhancement washout, and lower Ki-67 level. For qualitative indicators, the overlying vessel sign (86.67% vs. 44.44%, P = 0.027), prominent pulmonary artery sign (73.33% vs. 27.78%, P = 0.015), and obstructive inflammation/atelectasis (26.67% vs. 0%, P = 0.033) were more common in central PSPs, while peripheral PSPs were more common with halo sign (38.89% vs. 6.67%, P = 0.046).

Conclusions
The location of PSP is a possible contributing factor to its diverse imaging-pathological findings. The tumor size, multi-phase enhancement, qualitative signs, and Ki-67 were different between central and peripheral PSPs. Combined tumor size, multi-phase findings, and Ki-67 level are helpful to reveal the nature of the borderline tumor.

Central and peripheral pulmonary sclerosing pneumocytomas: multi-phase CT study and comparison with Ki-67

Affiliated Hospital of Yangzhou University

Affiliated Yantai Yuhuangding Hospital of Qingdao University

Radiology and Oncology

This work is licensed under the Creative Commons Attribution 4.0 International License.

Background
This study aimed to evaluate the multi-phase CT findings of central and peripheral pulmonary sclerosing pneumocytomas (PSPs) and compared them with...

Central and peripheral pulmonary sclerosing pneumocytomas: multi-phase CT study and comparison with Ki-67

Article Category: Research Article

Published Online: Sep 04, 2023

Page range: 310 - 316

Received: Apr 28, 2023

Accepted: Jul 21, 2023

DOI: https://doi.org/10.2478/raon-2023-0042

Keywords
pulmonary sclerosing pneumocytoma, location, multi-phase computed tomography, Ki-67

© 2023 Yanli Zhang et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Central and peripheral pulmonary sclerosing pneumocytomas: multi-phase CT study and comparison with Ki-67

Article Category: Research Article

Published Online: Sep 04, 2023

Page range: 310 - 316

Received: Apr 28, 2023

Accepted: Jul 21, 2023

DOI: https://doi.org/10.2478/raon-2023-0042

Keywordspulmonary sclerosing pneumocytoma, location, multi-phase computed tomography, Ki-67

© 2023 Yanli Zhang et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
pulmonary sclerosing pneumocytoma, location, multi-phase computed tomography, Ki-67