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The effects of normobaric and hyperbaric oxygenation on MRI signal intensities in T1-weighted, T2-weighted and FLAIR images in human brain

Vida Velej

Vida Velej

  • Institute of Physiology, Faculty of Medicine, University of LjubljanaLjubljana, Slovenia
  • Kranj Community Health Center, Gorenjska Basic HealthcareKranj, Slovenia
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Velej, Vida
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Ksenija Cankar

Ksenija Cankar

Institute of Physiology, Faculty of Medicine, University of LjubljanaLjubljana, Slovenia
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Cankar, Ksenija
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Jernej Vidmar

Jernej Vidmar

  • Institute of Physiology, Faculty of Medicine, University of LjubljanaLjubljana, Slovenia
  • Institute of Radiology, University Medical Center LjubljanaLjubljana, Slovenia
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Vidmar, Jernej
  
Sep 04, 2023
The effects of normobaric and hyperbaric oxygenation on MRI signal intensities in T1-weighted, T2-weighted and FLAIR images in human brain's Cover Image
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Article Category: Research Article
Published Online: Sep 04, 2023
Page range: 317 - 324
Received: May 29, 2023
Accepted: Jul 24, 2023
DOI: https://doi.org/10.2478/raon-2023-0043
Keywords
© 2023 Vida Velej et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.

Background

Dissolved oxygen has known paramagnetic effects in magnetic resonance imaging (MRI). The aim of this study was to compare the effects of normobaric oxygenation (NBO) and hyperbaric oxygenation (HBO) on human brain MRI signal intensities.

Patients and methods

Baseline brain MRI was performed in 17 healthy subjects (mean age 27.8 ± 3.2). MRI was repeated after exposure to the NBO and HBO at different time points (0 min, 25 min, 50 min). Signal intensities in T1-weighted, T2-weighted images and fluid attenuated inversion recovery (FLAIR) signal intensities of several intracranial structures were compared between NBO and HBO.

Results

Increased T1-weighted signal intensities were observed in white and deep grey brain matter, cerebrospinal fluid (CSF), venous blood and vitreous body after exposure to NBO as well as to HBO compared to baseline (Dunnett's test, p < 0.05) without significant differences between both protocols. There was also no significant difference in T2-weighted signal intensities between NBO and HBO. FLAIR signal intensities were increased only in the vitreous body after NBO and HBO and FLAIR signal of caudate nucleus was decreased after NBO (Dunnett's test, p < 0.05). The statistically significant differences in FLAIR signal intensities were found between NBO and HBO (paired t-test, p < 0.05) in most observed brain structures (paired t-test, p < 0.05).

Conclusions

Our results show that NBO and HBO alters signal intensities T1-weighted and FLAIR images of human brain. The differences between NBO and HBO are most pronounced in FLAIR imaging.
Language:
English
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Journal Subjects:
Medicine, Clinical Medicine, Internal Medicine, Haematology, Oncology, Radiology
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