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Comparing the diagnostic efficacy of [18F]FDG PET/CT and [18F]FDG PET/MRI for detecting bone metastases in breast cancer: a meta-analysis

Longjie Xia

Longjie Xia

  • Department of General Surgery, The First Affiliated Hospital of Jinan University, Jinan UniversityGuangzhou, China
  • Department of General Surgery, Guangzhou First People's Hospital, GuangzhouGuangzhou, China
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Xia, Longjie
, 
Jianqin Lai

Jianqin Lai

  • Department of General Surgery, The First Affiliated Hospital of Jinan University, Jinan UniversityGuangzhou, China
  • Department of General Surgery, Guangzhou First People's Hospital, GuangzhouGuangzhou, China
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Lai, Jianqin
, 
Di Huang

Di Huang

Department of General Surgery, Guangzhou First People's Hospital, GuangzhouGuangzhou, China
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Huang, Di
, 
Shenghui Qiu

Shenghui Qiu

  • Department of General Surgery, The First Affiliated Hospital of Jinan University, Jinan UniversityGuangzhou, China
  • Department of General Surgery, Guangzhou First People's Hospital, GuangzhouGuangzhou, China
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Qiu, Shenghui
, 
Huiqiong Hu

Huiqiong Hu

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Hu, Huiqiong
, 
Yunxiang Luo

Yunxiang Luo

Department of Plastic Surgery, The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou, China
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Luo, Yunxiang
 and 
Jie Cao

Jie Cao

  • Department of General Surgery, The First Affiliated Hospital of Jinan University, Jinan UniversityGuangzhou, China
  • Department of General Surgery, Guangzhou First People's Hospital, GuangzhouGuangzhou, China
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Cao, Jie
  
Jul 26, 2023
Comparing the diagnostic efficacy of [18F]FDG PET/CT and [18F]FDG PET/MRI for detecting bone metastases in breast cancer: a meta-analysis's Cover Image
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Article Category: Research Article
Published Online: Jul 26, 2023
Page range: 299 - 309
Received: Apr 01, 2023
Accepted: Jun 15, 2023
DOI: https://doi.org/10.2478/raon-2023-0037
Keywords
© 2023 Longjie Xia et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.

Background

This meta-analysis aimed to evaluate the comparative diagnostic efficacy of [18F]FDG PET/CT and [18F] FDG PET/MRI in detecting bone metastases in breast cancer patients.

Methods

An extensive search was conducted in the PubMed, Embase, Web of Science, and Cochrane Library databases to identify available publications up to February 2023. Studies were included if they evaluated the diagnostic efficacy of [18F]FDG PET/CT and [18F]FDG PET/MRI in patients with breast cancer bone metastases. Sensitivity and specificity were assessed using the DerSimonian and Laird method, followed by transformation via the Freeman-Tukey double inverse sine transformation.

Results

16 articles (including 4 head-to-head comparison articles) involving 1,261 patients were included in the meta-analysis. The overall sensitivity of [18F]FDG PET/CT in patient-based analysis, lesion-based analysis, and head-to-head comparison were 0.73, 0.89, and 0.87, respectively, while the overall sensitivity of [18F]FDG PET/MRI were 0.99, 0.99, and 0.99. The results indicated that [18F]FDG PET/MRI appears to a higher sensitivity in comparison to [18F]FDG PET/CT(all P < 0.05). In contrast, the overall specificity of [18F]FDG PET/CT in patient-based analysis, lesion-based analysis, and head-to-head comparison were 1.00, 0.99, and 1.00, respectively, while the overall specificity of [18F]FDG PET/MRI were 1.00, 0.99, and 0.98. These results suggested that [18F]FDG PET/CT has a similar level of specificity compared to [18F]FDG PET/MRI.

Conclusions

Our meta-analysis indicates that [18F]FDG PET/MRI demonstrates superior sensitivity and similar specificity to [18F]FDG PET/CT in detecting bone metastases in breast cancer patients. Further prospective research is required to confirm these findings and assess the clinical application of these techniques.
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English
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Journal Subjects:
Medicine, Clinical Medicine, Internal Medicine, Haematology, Oncology, Radiology
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