<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Background</h3>
This meta-analysis aimed to evaluate the comparative diagnostic efficacy of [18F]FDG PET/CT and [18F] FDG PET/MRI in detecting bone metastases in breast cancer patients.
</sec>
<sec><h3>Methods</h3>
An extensive search was conducted in the PubMed, Embase, Web of Science, and Cochrane Library databases to identify available publications up to February 2023. Studies were included if they evaluated the diagnostic efficacy of [18F]FDG PET/CT and [18F]FDG PET/MRI in patients with breast cancer bone metastases. Sensitivity and specificity were assessed using the DerSimonian and Laird method, followed by transformation via the Freeman-Tukey double inverse sine transformation.
</sec>
<sec><h3>Results</h3>
16 articles (including 4 head-to-head comparison articles) involving 1,261 patients were included in the meta-analysis. The overall sensitivity of [18F]FDG PET/CT in patient-based analysis, lesion-based analysis, and head-to-head comparison were 0.73, 0.89, and 0.87, respectively, while the overall sensitivity of [18F]FDG PET/MRI were 0.99, 0.99, and 0.99. The results indicated that [18F]FDG PET/MRI appears to a higher sensitivity in comparison to [18F]FDG PET/CT(all <italic>P</italic> &lt; 0.05). In contrast, the overall specificity of [18F]FDG PET/CT in patient-based analysis, lesion-based analysis, and head-to-head comparison were 1.00, 0.99, and 1.00, respectively, while the overall specificity of [18F]FDG PET/MRI were 1.00, 0.99, and 0.98. These results suggested that [18F]FDG PET/CT has a similar level of specificity compared to [18F]FDG PET/MRI.
</sec>
<sec><h3>Conclusions</h3>
Our meta-analysis indicates that [18F]FDG PET/MRI demonstrates superior sensitivity and similar specificity to [18F]FDG PET/CT in detecting bone metastases in breast cancer patients. Further prospective research is required to confirm these findings and assess the clinical application of these techniques.
</sec>
</abstract>

Background
This meta-analysis aimed to evaluate the comparative diagnostic efficacy of [18F]FDG PET/CT and [18F] FDG PET/MRI in detecting bone metastases in breast cancer patients.

Methods
An extensive search was conducted in the PubMed, Embase, Web of Science, and Cochrane Library databases to identify available publications up to February 2023. Studies were included if they evaluated the diagnostic efficacy of [18F]FDG PET/CT and [18F]FDG PET/MRI in patients with breast cancer bone metastases. Sensitivity and specificity were assessed using the DerSimonian and Laird method, followed by transformation via the Freeman-Tukey double inverse sine transformation.

Results
16 articles (including 4 head-to-head comparison articles) involving 1,261 patients were included in the meta-analysis. The overall sensitivity of [18F]FDG PET/CT in patient-based analysis, lesion-based analysis, and head-to-head comparison were 0.73, 0.89, and 0.87, respectively, while the overall sensitivity of [18F]FDG PET/MRI were 0.99, 0.99, and 0.99. The results indicated that [18F]FDG PET/MRI appears to a higher sensitivity in comparison to [18F]FDG PET/CT(all P < 0.05). In contrast, the overall specificity of [18F]FDG PET/CT in patient-based analysis, lesion-based analysis, and head-to-head comparison were 1.00, 0.99, and 1.00, respectively, while the overall specificity of [18F]FDG PET/MRI were 1.00, 0.99, and 0.98. These results suggested that [18F]FDG PET/CT has a similar level of specificity compared to [18F]FDG PET/MRI.

Conclusions
Our meta-analysis indicates that [18F]FDG PET/MRI demonstrates superior sensitivity and similar specificity to [18F]FDG PET/CT in detecting bone metastases in breast cancer patients. Further prospective research is required to confirm these findings and assess the clinical application of these techniques.

Comparing the diagnostic efficacy of [18F]FDG PET/CT and [18F]FDG PET/MRI for detecting bone metastases in breast cancer: a meta-analysis

The First Affiliated Hospital of Jinan University, Jinan University

Guangzhou First People's Hospital, Guangzhou

The First Affiliated Hospital of Sun Yat-sen University

Radiology and Oncology

This work is licensed under the Creative Commons Attribution 4.0 International License.

Comparing the diagnostic efficacy of [F]FDG PET/CT and [F]FDG PET/MRI for detecting bone metastases in breast cancer: a meta-analysis

Background
This meta-analysis aimed to evaluate the comparative diagnostic efficacy of [18F]FDG PET/CT and [18F] FDG PET/MRI in detecting bone metastases in...

Comparing the diagnostic efficacy of [¹⁸F]FDG PET/CT and [¹⁸F]FDG PET/MRI for detecting bone metastases in breast cancer: a meta-analysis

Article Category: Research Article

Published Online: Jul 26, 2023

Page range: 299 - 309

Received: Apr 01, 2023

Accepted: Jun 15, 2023

DOI: https://doi.org/10.2478/raon-2023-0037

Keywords
[F]FDG PET/CT, [F]FDG PET/MRI, bone metastases, breast cancer, meta-analysis

© 2023 Longjie Xia et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Supplementary Material Details

Comparing the diagnostic efficacy of [18F]FDG PET/CT and [18F]FDG PET/MRI for detecting bone metastases in breast cancer: a meta-analysis

Article Category: Research Article

Published Online: Jul 26, 2023

Page range: 299 - 309

Received: Apr 01, 2023

Accepted: Jun 15, 2023

DOI: https://doi.org/10.2478/raon-2023-0037

Keywords[F]FDG PET/CT, [F]FDG PET/MRI, bone metastases, breast cancer, meta-analysis

© 2023 Longjie Xia et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Supplementary Material Details

Comparing the diagnostic efficacy of [¹⁸F]FDG PET/CT and [¹⁸F]FDG PET/MRI for detecting bone metastases in breast cancer: a meta-analysis

Keywords
[F]FDG PET/CT, [F]FDG PET/MRI, bone metastases, breast cancer, meta-analysis