<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Background</h3>
<p>The aim of the study was to investigate the value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and intravoxel incoherent motion (IVIM) in differentiating TP53-mutant from wild type, low-risk from non-low-risk early-stage endometrial carcinoma (EC).</p>
</sec>
<sec><h3>Patients and methods</h3>
<p>A total of 74 EC patients underwent pelvic MRI. Parameters volume transfer constant (K<sup>trans</sup>), rate transfer constant (K<sub>ep</sub>), the volume of extravascular extracellular space per unit volume of tissue (V<sub>e</sub>), true diffusion coefficient (D), pseudo-diffusion coefficient (D*), and microvascular volume fraction (f) were compared. The combination of parameters was investigated by logistic regression and evaluated by bootstrap (1000 samples), receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA).</p>
</sec>
<sec><h3>Results</h3>
<p>In the TP53-mutant group, K<sup>trans</sup> and K<sub>ep</sub> were higher and D was lower than in the TP53-wild group; K<sup>trans</sup>, V<sub>e</sub>, f, and D were lower in the non-low-risk group than in the low-risk group (all P &lt; 0.05). In the identification of TP53-mutant and TP53-wild early-stage EC, K<sup>trans</sup> and D were independent predictors, and the combination of them had an optimal diagnostic efficacy (AUC, 0.867; sensitivity, 92.00%; specificity, 80.95%), which was significantly better than D (Z = 2.169, P = 0.030) and K<sup>trans</sup> (Z = 2.572, P = 0.010). In the identification of low-risk and non-low-risk early-stage EC, K<sup>trans</sup>, V<sub>e</sub>, and f were independent predictors, and the combination of them had an optimal diagnostic efficacy (AUC, 0.947; sensitivity, 83.33%; specificity, 93.18%), which was significantly better than D (Z = 3.113, P = 0.002), f (Z = 4.317, P &lt; 0.001), K<sup>trans</sup> (Z = 2.713, P = 0.007), and V<sub>e</sub> (Z = 3.175, P = 0.002). The calibration curves showed that the above two combinations of independent predictors, both have good consistency, and DCA showed that these combinations were reliable clinical prediction tools.</p>
</sec>
<sec><h3>Conclusions</h3>
<p>Both DCE-MRI and IVIM facilitate the prediction of TP53 status and risk stratification in early-stage EC. Compare with each single parameter, the combination of independent predictors provided better predictive power and may serve as a superior imaging marker.</p>
</sec>
</abstract>

Background
The aim of the study was to investigate the value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and intravoxel incoherent motion (IVIM) in differentiating TP53-mutant from wild type, low-risk from non-low-risk early-stage endometrial carcinoma (EC).

Patients and methods
A total of 74 EC patients underwent pelvic MRI. Parameters volume transfer constant (Ktrans), rate transfer constant (Kep), the volume of extravascular extracellular space per unit volume of tissue (Ve), true diffusion coefficient (D), pseudo-diffusion coefficient (D*), and microvascular volume fraction (f) were compared. The combination of parameters was investigated by logistic regression and evaluated by bootstrap (1000 samples), receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA).

Results
In the TP53-mutant group, Ktrans and Kep were higher and D was lower than in the TP53-wild group; Ktrans, Ve, f, and D were lower in the non-low-risk group than in the low-risk group (all P < 0.05). In the identification of TP53-mutant and TP53-wild early-stage EC, Ktrans and D were independent predictors, and the combination of them had an optimal diagnostic efficacy (AUC, 0.867; sensitivity, 92.00%; specificity, 80.95%), which was significantly better than D (Z = 2.169, P = 0.030) and Ktrans (Z = 2.572, P = 0.010). In the identification of low-risk and non-low-risk early-stage EC, Ktrans, Ve, and f were independent predictors, and the combination of them had an optimal diagnostic efficacy (AUC, 0.947; sensitivity, 83.33%; specificity, 93.18%), which was significantly better than D (Z = 3.113, P = 0.002), f (Z = 4.317, P < 0.001), Ktrans (Z = 2.713, P = 0.007), and Ve (Z = 3.175, P = 0.002). The calibration curves showed that the above two combinations of independent predictors, both have good consistency, and DCA showed that these combinations were reliable clinical prediction tools.

Conclusions
Both DCE-MRI and IVIM facilitate the prediction of TP53 status and risk stratification in early-stage EC. Compare with each single parameter, the combination of independent predictors provided better predictive power and may serve as a superior imaging marker.

Quantitative dynamic contrast-enhanced parameters and intravoxel incoherent motion facilitate the prediction of TP53 status and risk stratification of early-stage endometrial carcinoma

the First Affiliated Hospital of Xinxiang Medical University

Radiology and Oncology

This work is licensed under the Creative Commons Attribution 4.0 International License.

Background
The aim of the study was to investigate the value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and intravoxel incoherent motion...

Quantitative dynamic contrast-enhanced parameters and intravoxel incoherent motion facilitate the prediction of TP53 status and risk stratification of early-stage endometrial carcinoma

Article Category: Research Article

Published Online: Jun 21, 2023

Page range: 257 - 269

Received: Feb 09, 2023

Accepted: Apr 06, 2023

DOI: https://doi.org/10.2478/raon-2023-0023

Keywords
early-stage endometrial carcinoma, dynamic contrast-enhanced MRI, intravoxel incoherent motion, p53 status, risk stratification

© 2023 Hongxia Wang et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Quantitative dynamic contrast-enhanced parameters and intravoxel incoherent motion facilitate the prediction of TP53 status and risk stratification of early-stage endometrial carcinoma

Article Category: Research Article

Published Online: Jun 21, 2023

Page range: 257 - 269

Received: Feb 09, 2023

Accepted: Apr 06, 2023

DOI: https://doi.org/10.2478/raon-2023-0023

Keywordsearly-stage endometrial carcinoma, dynamic contrast-enhanced MRI, intravoxel incoherent motion, p53 status, risk stratification

© 2023 Hongxia Wang et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
early-stage endometrial carcinoma, dynamic contrast-enhanced MRI, intravoxel incoherent motion, p53 status, risk stratification