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Longitudinal monitoring of Apparent Diffusion Coefficient (ADC) in patients with prostate cancer undergoing MR-guided radiotherapy on an MR-Linac at 1.5 T: a prospective feasibility study

Haidara Almansour

Haidara Almansour

Department of Diagnostic and Interventional Radiology, Eberhard-Karls UniversityTuebingen, Germany
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Almansour, Haidara
, 
Fritz Schick

Fritz Schick

Section for Experimental Radiology, Department of Radiology, Eberhard-Karls UniversityTuebingen, Germany
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Schick, Fritz
, 
Marcel Nachbar

Marcel Nachbar

  • Department of Radiation Oncology, Charité University Medicine BerlinBerlin, Germany
  • Section for Biomedical Physics, Department of Radiation Oncology, Eberhard-Karls UniversityTuebingen, Germany
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Nachbar, Marcel
, 
Saif Afat

Saif Afat

Department of Diagnostic and Interventional Radiology, Eberhard-Karls UniversityTuebingen, Germany
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Afat, Saif
, 
Victor Fritz

Victor Fritz

Section for Experimental Radiology, Department of Radiology, Eberhard-Karls UniversityTuebingen, Germany
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Fritz, Victor
, 
Daniela Thorwarth

Daniela Thorwarth

  • Section for Biomedical Physics, Department of Radiation Oncology, Eberhard-Karls UniversityTuebingen, Germany
  • German Cancer Consortium (DKTK), Partner Site Tuebingen and German Cancer Research Center (DKFZ)Heidelberg, Germany
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Thorwarth, Daniela
, 
Daniel Zips

Daniel Zips

  • Department of Radiation Oncology, Charité University Medicine BerlinBerlin, Germany
  • German Cancer Consortium (DKTK), Partner Site Tuebingen and German Cancer Research Center (DKFZ)Heidelberg, Germany
  • Department of Radiation Oncology, Eberhard-Karls UniversityTuebingen, Germany
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Zips, Daniel
, 
Felix Bertram

Felix Bertram

Department of Radiation Oncology, Eberhard-Karls UniversityTuebingen, Germany
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Bertram, Felix
, 
Arndt-Christian Müller

Arndt-Christian Müller

  • Department of Radiation Oncology, Eberhard-Karls UniversityTuebingen, Germany
  • Department of Radiation Oncology, RKH Klinikum LudwigsburgLudwigsburg, Germany
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Müller, Arndt-Christian
, 
Konstantin Nikolaou

Konstantin Nikolaou

  • Department of Diagnostic and Interventional Radiology, Eberhard-Karls UniversityTuebingen, Germany
  • Cluster of Excellence iFIT (EXC 2180) “Image Guided and Functionally Instructed Tumor Therapies”, University of TuebingenTuebingen, Germany
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Nikolaou, Konstantin
, 
Ahmed E Othman

Ahmed E Othman

  • Department of Diagnostic and Interventional Radiology, Eberhard-Karls UniversityTuebingen, Germany
  • Department of Neuroradiology, University Medical Center MainzMainz, Germany
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Othman, Ahmed E
 and 
Daniel Wegener

Daniel Wegener

Department of Radiation Oncology, Eberhard-Karls UniversityTuebingen, Germany
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Wegener, Daniel
  
Jun 21, 2023
Longitudinal monitoring of Apparent Diffusion Coefficient (ADC) in patients with prostate cancer undergoing MR-guided radiotherapy on an MR-Linac at 1.5 T: a prospective feasibility study's Cover Image
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Article Category: Research Article
Published Online: Jun 21, 2023
Page range: 184 - 190
Received: Jan 20, 2023
Accepted: Mar 30, 2023
DOI: https://doi.org/10.2478/raon-2023-0020
Keywords
© 2023 Haidara Almansour et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.

FIGURE 1.

Flow diagram illustrating the inclusion/exclusion process.
Flow diagram illustrating the inclusion/exclusion process.

FIGURE 2.

T2-weighted MR images (scan time: 2 minutes) and apparent diffusion coefficient (ADC) maps of a 66-year-old male patient with prostate cancer in the antero-apical region of the transition zone (red arrows) at baseline (left column) and during radiotherapy (right column) as recorded on MR-Linac (MRL) and on standard MRI at 3T (MRI3T). The figure shows similar dynamics of lesion ADC elevation during radiotherapy.
T2-weighted MR images (scan time: 2 minutes) and apparent diffusion coefficient (ADC) maps of a 66-year-old male patient with prostate cancer in the antero-apical region of the transition zone (red arrows) at baseline (left column) and during radiotherapy (right column) as recorded on MR-Linac (MRL) and on standard MRI at 3T (MRI3T). The figure shows similar dynamics of lesion ADC elevation during radiotherapy.

FIGURE 3.

Scatter plots with a fitted line for ADC values as recorded on MR-Linac and MRI3T for reader 1. (A) at baseline, (B) during radiotherapy (week 2). These plots illustrate the strong positive correlation between MRL-ADC and MRI3T-ADC at both time points.
Scatter plots with a fitted line for ADC values as recorded on MR-Linac and MRI3T for reader 1. (A) at baseline, (B) during radiotherapy (week 2). These plots illustrate the strong positive correlation between MRL-ADC and MRI3T-ADC at both time points.
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English
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Journal Subjects:
Medicine, Clinical Medicine, Internal Medicine, Haematology, Oncology, Radiology
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