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Percutaneous electrochemotherapy in primary and secondary liver malignancies – local tumor control and impact on overall survival


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Global Burden of Disease Cancer Collaboration; Fitzmaurice C, Allen C, Barber RM, Barregard L, Bhutta ZA, Brenner H, et al. Global, regional, and national cancer Incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: a systematic analysis for the Global Burden of Disease Study. JAMA Oncol 2017; 3: 524. doi: 10.1001/jamaoncol.2016.5688 Global Burden of Disease Cancer Collaboration; Fitzmaurice C Allen C Barber RM Barregard L Bhutta ZA Brenner H et al Global, regional, and national cancer Incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: a systematic analysis for the Global Burden of Disease Study JAMA Oncol 2017 3 524 10.1001/jamaoncol.2016.5688Open DOISearch in Google Scholar

Valery PC, Laversanne M, Clark PJ, Petrick JL, McGlynn KA, Bray F. Projections of primary liver cancer to 2030 in 30 countries worldwide. Hepatology 2018; 67: 600-11. doi: 10.1002/hep.29498 Valery PC Laversanne M Clark PJ Petrick JL McGlynn KA Bray F Projections of primary liver cancer to 2030 in 30 countries worldwide Hepatology 2018 67 600 11 10.1002/hep.29498Open DOISearch in Google Scholar

Engstrand J, Nilsson H, Strömberg C, Jonas E, Freedman J. Colorectal cancer liver metastases – a population-based study on incidence, management and survival. BMC Cancer 2018; 18: 78. doi: 10.1186/s12885-017-3925-x Engstrand J Nilsson H Strömberg C Jonas E Freedman J Colorectal cancer liver metastases – a population-based study on incidence, management and survival BMC Cancer 2018 18 78 10.1186/s12885-017-3925-xOpen DOISearch in Google Scholar

Hackl C, Neumann P, Gerken M, Loss M, Klinkhammer-Schalke M, Schlitt HJ. Treatment of colorectal liver metastases in Germany: a ten-year population-based analysis of 5772 cases of primary colorectal adenocarcinoma. BMC Cancer 2014; 14: 810. doi: 10.1186/1471-2407-14-810 Hackl C Neumann P Gerken M Loss M Klinkhammer-Schalke M Schlitt HJ Treatment of colorectal liver metastases in Germany: a ten-year population-based analysis of 5772 cases of primary colorectal adenocarcinoma BMC Cancer 2014 14 810 10.1186/1471-2407-14-810Open DOISearch in Google Scholar

Van Cutsem E, Cervantes A, Adam R, Sobrero A, Van Krieken JH, Aderka D, et al. ESMO consensus guidelines for the management of patients with metastatic colorectal cancer. Ann Oncol 2016; 27: 1386-422. doi: 10.1093/annonc/mdw235 Van Cutsem E Cervantes A Adam R Sobrero A Van Krieken JH Aderka D et al ESMO consensus guidelines for the management of patients with metastatic colorectal cancer Ann Oncol 2016 27 1386 422 10.1093/annonc/mdw235Open DOISearch in Google Scholar

Goldberg SN, Gazelle GS, Mueller PR. Thermal ablation therapy for focal malignancy: a unified approach to underlying principles, techniques, and diagnostic imaging guidance. Am J Roentgenol 2000; 174: 323-31. doi: 10.2214/ajr.174.2.1740323 Goldberg SN Gazelle GS Mueller PR Thermal ablation therapy for focal malignancy: a unified approach to underlying principles, techniques, and diagnostic imaging guidance Am J Roentgenol 2000 174 323 31 10.2214/ajr.174.2.1740323Open DOISearch in Google Scholar

Glass LF, Jaroszeski M, Gilbert R, Reintgen DS, Heller R. Intralesional bleomy-cin-mediated electrochemotherapy in 20 patients with basal cell carcinoma. J Am Acad Dermatol 1997; 37: 596-9. doi: 10.1016/S0190-9622(97)70178-6 Glass LF Jaroszeski M Gilbert R Reintgen DS Heller R Intralesional bleomy-cin-mediated electrochemotherapy in 20 patients with basal cell carcinoma J Am Acad Dermatol 1997 37 596 9 10.1016/S0190-9622(97)70178-6Open DOISearch in Google Scholar

Marty M, Sersa G, Garbay JR, Gehl J, Collins CG, Snoj M, et al. Electrochemotherapy – an easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: results of ESOPE (European Standard Operating Procedures of Electrochemotherapy) study. Eur J Cancer Suppl 2006; 4: 3-13. doi: 10.1016/j.ejcsup.2006.08.002 Marty M Sersa G Garbay JR Gehl J Collins CG Snoj M et al Electrochemotherapy – an easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: results of ESOPE (European Standard Operating Procedures of Electrochemotherapy) study Eur J Cancer Suppl 2006 4 3 13 10.1016/j.ejcsup.2006.08.002Open DOISearch in Google Scholar

Clover AJP, de Terlizzi F, Bertino G, Curatolo P, Odili J, Campana LG, et al. Electrochemotherapy in the treatment of cutaneous malignancy: outcomes and subgroup analysis from the cumulative results from the pan-European International Network for Sharing Practice in Electrochemotherapy database for 2482 lesions in 987 patients (2008–2019). Eur J Cancer 2020; 138: 30-40. doi: 10.1016/j.ejca.2020.06.020 Clover AJP de Terlizzi F Bertino G Curatolo P Odili J Campana LG et al Electrochemotherapy in the treatment of cutaneous malignancy: outcomes and subgroup analysis from the cumulative results from the pan-European International Network for Sharing Practice in Electrochemotherapy database for 2482 lesions in 987 patients (2008–2019) Eur J Cancer 2020 138 30 40 10.1016/j.ejca.2020.06.020Open DOISearch in Google Scholar

Plaschke CC, Bertino G, McCaul JA, Grau JJ, de Bree R, Sersa G, et al. European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project: results from the treatment of mucosal cancers. Eur J Cancer 2017; 87: 172-81. doi: 10.1016/j.ejca.2017.10.008 Plaschke CC Bertino G McCaul JA Grau JJ de Bree R Sersa G et al European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project: results from the treatment of mucosal cancers Eur J Cancer 2017 87 172 81 10.1016/j.ejca.2017.10.008Open DOISearch in Google Scholar

Bertino G, Sersa G, De Terlizzi F, Occhini A, Plaschke CC, Groselj A, et al. European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project: results of the treatment of skin cancer. Eur J Cancer 2016; 63: 41-52. doi: 10.1016/j.ejca.2016.05.001 Bertino G Sersa G De Terlizzi F Occhini A Plaschke CC Groselj A et al European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project: results of the treatment of skin cancer Eur J Cancer 2016 63 41 52 10.1016/j.ejca.2016.05.001Open DOISearch in Google Scholar

Gasljevic G, Edhemovic I, Cemazar M, Brecelj E, Gadzijev EM, Music MM, et al. Histopathological findings in colorectal liver metastases after electrochemotherapy. PLoS ONE 2017; 12: e0180709. doi: 10.1371/journal. pone.0180709 Gasljevic G Edhemovic I Cemazar M Brecelj E Gadzijev EM Music MM et al Histopathological findings in colorectal liver metastases after electrochemotherapy PLoS ONE 2017 12 e0180709 10.1371/journal.pone.0180709Open DOISearch in Google Scholar

Brloznik M, Boc N, Sersa G, Zmuc J, Gasljevic G, Seliskar A, et al. Radiological findings of porcine liver after electrochemotherapy with bleomycin. Radiol Oncol 2019; 53: 415-26. doi: 10.2478/raon-2019-0049 Brloznik M Boc N Sersa G Zmuc J Gasljevic G Seliskar A et al Radiological findings of porcine liver after electrochemotherapy with bleomycin Radiol Oncol 2019 53 415 26 10.2478/raon-2019-0049Open DOISearch in Google Scholar

Zmuc J, Gasljevic G, Sersa G, Edhemovic I, Boc N, Seliskar A, et al. Large Liver Blood Vessels and Bile Ducts Are Not Damaged by Electrochemotherapy with Bleomycin in Pigs. Sci Rep 2019; 9: 3649. doi: 10.1038/s41598-019-40395-y Zmuc J Gasljevic G Sersa G Edhemovic I Boc N Seliskar A et al Large Liver Blood Vessels and Bile Ducts Are Not Damaged by Electrochemotherapy with Bleomycin in Pigs Sci Rep 2019 9 3649 10.1038/s41598-019-40395-yOpen DOISearch in Google Scholar

Cornelis FH, Korenbaum C, Ben Ammar M, Tavolaro S, Nouri-Neuville M, Lotz JP. Multimodal image-guided electrochemotherapy of unresectable liver metastasis from renal cell cancer. Diagn Interv Imag 2019; 100: 309-11. doi: 10.1016/j.diii.2019.01.001 Cornelis FH Korenbaum C Ben Ammar M Tavolaro S Nouri-Neuville M Lotz JP Multimodal image-guided electrochemotherapy of unresectable liver metastasis from renal cell cancer Diagn Interv Imag 2019 100 309 11 10.1016/j.diii.2019.01.001Open DOISearch in Google Scholar

Edhemovic I, Brecelj E, Cemazar M, Boc N, Trotovsek B, Djokic M, et al. Intraoperative electrochemotherapy of colorectal liver metastases: a prospective phase II study. EJSO 2020; 46: 1628-33. doi: 10.1016/j. ejso.2020.04.037 Edhemovic I Brecelj E Cemazar M Boc N Trotovsek B Djokic M et al Intraoperative electrochemotherapy of colorectal liver metastases: a prospective phase II study EJSO 2020 46 1628 33 10.1016/j.ejso.2020.04.037Open DOISearch in Google Scholar

Mali B, Gorjup V, Edhemovic I, Brecelj E, Cemazar M, Sersa G, et al. Electrochemotherapy of colorectal liver metastases - an observational study of its effects on the electrocardiogram. BioMed Eng OnLine 2015; 14(Suppl 3): S5. doi: 10.1186/1475-925X-14-S3-S5 Mali B Gorjup V Edhemovic I Brecelj E Cemazar M Sersa G et al Electrochemotherapy of colorectal liver metastases - an observational study of its effects on the electrocardiogram BioMed Eng OnLine 2015 14 Suppl 3 S5 10.1186/1475-925X-14-S3-S5Open DOISearch in Google Scholar

Jarm T, Krmac T, Magjarevic R, Kos B, Cindric H, Miklavcic D. Investigation of safety for electrochemotherapy and irreversible electroporation ablation therapies in patients with cardiac pacemakers. BioMed Eng OnLine 2020; 19: 85. doi: 10.1186/s12938-020-00827-7 Jarm T Krmac T Magjarevic R Kos B Cindric H Miklavcic D Investigation of safety for electrochemotherapy and irreversible electroporation ablation therapies in patients with cardiac pacemakers BioMed Eng OnLine 2020 19 85 10.1186/s12938-020-00827-7Open DOISearch in Google Scholar

Boc N, Edhemovic I, Kos B, Marolt Music M, Brecelj E, Trotovsek B, et al. Ultrasonographic changes in the liver tumors as indicators of adequate tumor coverage with electric field for effective electrochemotherapy. Radiol Oncol 2018; 52: 383-91. doi: 10.2478/raon-2018-0041 Boc N Edhemovic I Kos B Marolt Music M Brecelj E Trotovsek B et al Ultrasonographic changes in the liver tumors as indicators of adequate tumor coverage with electric field for effective electrochemotherapy Radiol Oncol 2018 52 383 91 10.2478/raon-2018-0041Open DOISearch in Google Scholar

Bertacchini C. Cliniporator: medical electroporation of tumors. In: Miklavcic D, editor. Handbook of Electroporation. Cham: Springer International Publishing; 2017. p. 1-36. Bertacchini C Cliniporator: medical electroporation of tumors. In: Miklavcic D, editor. Handbook of Electroporation. Cham Springer International Publishing; 2017 p 1 3610.1007/978-3-319-26779-1_214-1Search in Google Scholar

Gehl J, Sersa G, Matthiessen LW, Muir T, Soden D, Occhini A, et al. Updated standard operating procedures for electrochemotherapy of cutaneous tumours and skin metastases. Acta Oncol 2018; 57: 874-82. doi: 10.1080/0284186X.2018.1454602 Gehl J Sersa G Matthiessen LW Muir T Soden D Occhini A et al Updated standard operating procedures for electrochemotherapy of cutaneous tumours and skin metastases Acta Oncol 2018 57 874 82 10.1080/0284186X.2018.1454602Open DOISearch in Google Scholar

Ruers T, Van Coevorden F, Punt CJ, Pierie JE, Borel-Rinkes I, Ledermann JA, et al. Local treatment of unresectable colorectal liver metastases: results of a randomized phase ii trial. J Natl Cancer I 2017; 109: djx015. doi: 10.1093/jnci/djx015 Ruers T Van Coevorden F Punt CJ Pierie JE Borel-Rinkes I Ledermann JA et al Local treatment of unresectable colorectal liver metastases: results of a randomized phase ii trial J Natl Cancer I 2017 109 djx015 10.1093/jnci/djx015Open DOISearch in Google Scholar

Slovak R, Ludwig JM, Gettinger SN, Herbst RS, Kim HS. Immuno-thermal ablations - boosting the anticancer immune response. J Immunother Cancer 2017; 5: 78. doi: 10.1186/s40425-017-0284-8 Slovak R Ludwig JM Gettinger SN Herbst RS Kim HS Immuno-thermal ablations - boosting the anticancer immune response J Immunother Cancer 2017 5 78 10.1186/s40425-017-0284-8Open DOISearch in Google Scholar

Camacho JC, Petre EN, Sofocleous CT. Thermal ablation of metastatic colon cancer to the liver. Semin Intervent Radiol 2019; 36: 310-8. doi: 10.1055/s-0039-1698754 Camacho JC Petre EN Sofocleous CT Thermal ablation of metastatic colon cancer to the liver Semin Intervent Radiol 2019 36 310 8 10.1055/s-0039-1698754Open DOISearch in Google Scholar

Olson R, Mathews L, Liu M, Schellenberg D, Mou B, Berrang T, et al. Stereotactic ablative radiotherapy for the comprehensive treatment of 1–3 Oligometastatic tumors (SABR-COMET-3): study protocol for a randomized phase III trial. BMC Cancer 2020; 20: 380. doi: 10.1186/s12885-020-06876-4 Olson R Mathews L Liu M Schellenberg D Mou B Berrang T et al Stereotactic ablative radiotherapy for the comprehensive treatment of 1–3 Oligometastatic tumors (SABR-COMET-3): study protocol for a randomized phase III trial BMC Cancer 2020 20 380 10.1186/s12885-020-06876-4Open DOISearch in Google Scholar

Kovács A, Bischoff P, Haddad H, Kovács G, Schaefer A, Zhou W, et al. Personalized image-guided therapies for local malignencies: interdisciplinary options for interventional radiology and interventional radiotherapy. Front Oncol 2021; 11: 616058. doi: 10.3389/fonc.2021.616058 Kovács A Bischoff P Haddad H Kovács G Schaefer A Zhou W et al Personalized image-guided therapies for local malignencies: interdisciplinary options for interventional radiology and interventional radiotherapy Front Oncol 2021 11 616058 10.3389/fonc.2021.616058Open DOISearch in Google Scholar

Campanacci L, Bianchi G, Cevolani L, Errani C, Ciani G, Facchini G, et al. Operating procedures for electrochemotherapy in bone metastases: results from a multicenter prospective study on 102 patients. Eur J Surg Oncol 2021; 47: 2609-17. doi: 10.1016/j.ejso.2021.05.004 Campanacci L Bianchi G Cevolani L Errani C Ciani G Facchini G et al Operating procedures for electrochemotherapy in bone metastases: results from a multicenter prospective study on 102 patients Eur J Surg Oncol 2021 47 2609 17 10.1016/j.ejso.2021.05.004Open DOISearch in Google Scholar

Edhemovic I, Gadzijev EM, Brecelj E, Miklavcic D, Kos B, Zupanic A, et al. Electrochemotherapy: a new technological approach in treatment of metastases in the liver. Technol Cancer Res Treat 2011; 10: 475-85. doi: 10.7785/tcrt.2012.500224 Edhemovic I Gadzijev EM Brecelj E Miklavcic D Kos B Zupanic A et al Electrochemotherapy: a new technological approach in treatment of metastases in the liver Technol Cancer Res Treat 2011 10 475 85 10.7785/tcrt.2012.500224Open DOISearch in Google Scholar

Edhemovic I, Brecelj E, Gasljevic G, Marolt Music M, Gorjup V, Mali B, et al. Intraoperative electrochemotherapy of colorectal liver metastases. J Surg Oncol 2014; 110: 320-7. doi: 10.1002/jso.23625 Edhemovic I Brecelj E Gasljevic G Marolt Music M Gorjup V Mali B et al Intraoperative electrochemotherapy of colorectal liver metastases J Surg Oncol 2014 110 320 7 10.1002/jso.23625Open DOISearch in Google Scholar

Coletti L, Battaglia V, De Simone P, Turturici L, Bartolozzi C, Filipponi F. Safety and feasibility of electrochemotherapy in patients with unresectable colorectal liver metastases: a pilot study. Int J Surg 2017; 44: 26-32. doi: 10.1016/j.ijsu.2017.06.033 Coletti L Battaglia V De Simone P Turturici L Bartolozzi C Filipponi F Safety and feasibility of electrochemotherapy in patients with unresectable colorectal liver metastases: a pilot study Int J Surg 2017 44 26 32 10.1016/j.ijsu.2017.06.033Open DOISearch in Google Scholar

Djokic M, Cemazar M, Popovic P, Kos B, Dezman R, Bosnjak M, et al. Electrochemotherapy as treatment option for hepatocellular carcinoma, a prospective pilot study. EJSO 2018; 44: 651-7. doi: 10.1016/j. ejso.2018.01.090 Djokic M Cemazar M Popovic P Kos B Dezman R Bosnjak M et al Electrochemotherapy as treatment option for hepatocellular carcinoma, a prospective pilot study EJSO 2018 44 651 7 10.1016/j.ejso.2018.01.090Open DOISearch in Google Scholar

Djokic M, Dezman R, Cemazar M, Stabuc M, Petric M, Smid LM, et al. Percutaneous image guided electrochemotherapy of hepatocellular carcinoma: technological advancement. Radiol Oncol 2020; 54: 347-52. doi: 10.2478/raon-2020-0038 Djokic M Dezman R Cemazar M Stabuc M Petric M Smid LM et al Percutaneous image guided electrochemotherapy of hepatocellular carcinoma: technological advancement Radiol Oncol 2020 54 347 52 10.2478/raon-2020-0038Open DOISearch in Google Scholar

Tarantino L, Busto G, Nasto A, Nasto RA, Tarantino P, Fristachi R, et al. Electrochemotherapy of cholangiocellular carcinoma at hepatic hilum: a feasibility study. EJSO 2018; 44: 1603-9. doi: 10.1016/j.ejso.2018.06.025 Tarantino L Busto G Nasto A Nasto RA Tarantino P Fristachi R et al Electrochemotherapy of cholangiocellular carcinoma at hepatic hilum: a feasibility study EJSO 2018 44 1603 9 10.1016/j.ejso.2018.06.025Open DOISearch in Google Scholar

Granata V, Palaia R, Albino V, Piccirillo M, Venanzio Setola S, Petrillo A, et al. Electrochemotherapy of cholangiocellular carcinoma at hepatic hilum: a case report. Eur Rev Med Pharmacol Sci 2020; 24: 7051-7. doi: 10.26355/eurrev_202006_21698 Granata V Palaia R Albino V Piccirillo M Venanzio Setola S Petrillo A et al Electrochemotherapy of cholangiocellular carcinoma at hepatic hilum: a case report Eur Rev Med Pharmacol Sci 2020 24 7051 7 10.26355/eurrev_202006_21698Open DOISearch in Google Scholar

Corrado G, Cutillo G, Fragomeni SM, Bruno V, Tagliaferri L, Mancini E, et al. Palliative electrochemotherapy in primary or recurrent vulvar cancer. Int J Gynecol Cancer 2020; 30: 927-31. doi: 10.1136/ijgc-2019-001178 Corrado G Cutillo G Fragomeni SM Bruno V Tagliaferri L Mancini E et al Palliative electrochemotherapy in primary or recurrent vulvar cancer Int J Gynecol Cancer 2020 30 927 31 10.1136/ijgc-2019-001178Open DOISearch in Google Scholar

Perrone AM, Galuppi A, Pirovano C, Borghese G, Covarelli P, De Terlizzi F, et al. Palliative Electrochemotherapy in vulvar carcinoma: preliminary results of the ELECHTRA (Electrochemotherapy Vulvar Cancer) multicenter study. Cancers 2019; 11: 657. doi: 10.3390/cancers11050657 Perrone AM Galuppi A Pirovano C Borghese G Covarelli P De Terlizzi F et al Palliative Electrochemotherapy in vulvar carcinoma: preliminary results of the ELECHTRA (Electrochemotherapy Vulvar Cancer) multicenter study Cancers 2019 11 657 10.3390/cancers11050657Open DOISearch in Google Scholar

Perrone AM, Ferioli M, Argnani L, De Terlizzi F, Pirovano C, Covarelli P, et al. Quality of life with vulvar carcinoma treated with palliative electrochemotherapy: The ELECHTRA (ELEctroCHemoTherapy vulvaR cAncer) Study. Cancers 2021; 13: 1622. doi: 10.3390/cancers13071622 Perrone AM Ferioli M Argnani L De Terlizzi F Pirovano C Covarelli P et al Quality of life with vulvar carcinoma treated with palliative electrochemotherapy: The ELECHTRA (ELEctroCHemoTherapy vulvaR cAncer) Study Cancers 2021 13 1622 10.3390/cancers13071622Open DOISearch in Google Scholar

Andresciani F, Faiella E, Altomare C, Pacella G, Beomonte Zobel B, Grasso RF. Reversible electrochemotherapy (ECT) as a treatment option for local RCC recurrence in solitary kidney. Cardiovasc Intervent Radiol 2020; 43: 1091-4. doi: 10.1007/s00270-020-02498-2 Andresciani F Faiella E Altomare C Pacella G Beomonte Zobel B Grasso RF Reversible electrochemotherapy (ECT) as a treatment option for local RCC recurrence in solitary kidney Cardiovasc Intervent Radiol 2020 43 1091 4 10.1007/s00270-020-02498-2Open DOISearch in Google Scholar

Tarantino L, Busto G, Nasto A, Fristachi R, Cacace L, Talamo M, et al. Percutaneous electrochemotherapy in the treatment of portal vein tumor thrombosis at hepatic hilum in patients with hepatocellular carcinoma in cirrhosis: A feasibility study. WJG 2017; 23: 906. doi: 10.3748/wjg.v23.i5.906 Tarantino L Busto G Nasto A Fristachi R Cacace L Talamo M et al Percutaneous electrochemotherapy in the treatment of portal vein tumor thrombosis at hepatic hilum in patients with hepatocellular carcinoma in cirrhosis: A feasibility study WJG 2017 23 906 10.3748/wjg.v23.i5.906Open DOISearch in Google Scholar

Liu F, Chen M, Mei J, Xu L, Guo R, Lin X, et al. Transarterial chemoembolization combined with radiofrequency ablation in the treatment of stage B1 intermediate hepatocellular carcinoma. J Oncol 2019; 2019: 1-7. doi: 10.1155/2019/6298502 Liu F Chen M Mei J Xu L Guo R Lin X et al Transarterial chemoembolization combined with radiofrequency ablation in the treatment of stage B1 intermediate hepatocellular carcinoma J Oncol 2019 2019 1 7 10.1155/2019/6298502Open DOISearch in Google Scholar

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Language:
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Journal Subjects:
Medicine, Clinical Medicine, Internal Medicine, Haematology, Oncology, Radiology