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Pneumologia
Volume 68 (2019): Issue 1 (June 2019)
Open Access
Pneumococcal pneumonia and invasive pneumococcal disease: immunopathogenesis and diagnosis
Gina Amanda
Gina Amanda
,
Dianiati Kusumo Sutoyo
Dianiati Kusumo Sutoyo
and
Erlina Burhan
Erlina Burhan
| Jul 02, 2019
Pneumologia
Volume 68 (2019): Issue 1 (June 2019)
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Article Category:
Reviews
Published Online:
Jul 02, 2019
Page range:
8 - 14
DOI:
https://doi.org/10.2478/pneum-2019-0009
Keywords
Streptococcus pneumoniae
,
polysaccharide capsule
,
serotype
,
pneumococcal pneumonia
,
invasive pneumococcal disease
© 2019 Amanda et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Figure 1
Virulence factors of S. pneumoniae. The figure is adapted with modification from Van der Poll T, Opal SM. Pathogenesis, treatment, and prevention of pneumococcal pneumonia. Lancet 2009;374(9700):1543-56. S. pneumoniae, Streptococcus pneumoniae.PsA = pneumococcal surface antigen A. PiaA/PiuA = pneumococcal iron acquisition and uptake. PspR = pneumococcal serine-rich repeat protein. PavA = pneumococcal adhesion and virulence. LTA = lipoteichoic acid.
Figure 2
Mechanism of pneumococcal colonization in the respiratory tract. The figure is adapted with modification from Wyllie AL, Rümke LW, Arp K, Bosch AA, Bruin JP, Rots NY, et al. Molecular surveillance on Streptococcus pneumoniae carriage in non-elderly adults; little evidence for pneumococcal circulation independent from the reservoir in children. Sci Rep 2016;6:34888.
Figure 3
Mechanism of pneumococcal invasion from the respiratory tract to the bloodstream and CSF. The figure is adapted with modification from Wyllie AL, Rümke LW, Arp K, Bosch AA, Bruin JP, Rots NY, et al. Molecular surveillance on Streptococcus pneumoniae carriage in non-elderly adults; little evidence for pneumococcal circulation independent from the reservoir in children. Sci Rep 2016;6:34888. CSF, cerebrospinal fluid.