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Stable aqueous dispersions of bare and double layer functionalized superparamagnetic iron oxide nanoparticles for biomedical applications

Jano Markhulia

Jano Markhulia

Vladimer Chavchanidze Institute of Cybernetics of the Georgian Technical UniversityTbilisi, Georgia
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Markhulia, Jano
, 
Shalva Kekutia

Shalva Kekutia

Vladimer Chavchanidze Institute of Cybernetics of the Georgian Technical UniversityTbilisi, Georgia
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Kekutia, Shalva
, 
Vladimer Mikelashvili

Vladimer Mikelashvili

Vladimer Chavchanidze Institute of Cybernetics of the Georgian Technical UniversityTbilisi, Georgia
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Mikelashvili, Vladimer
, 
László Almásy

László Almásy

Centre for Energy ResearchBudapest, Hungary
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Almásy, László
, 
Liana Saneblidze

Liana Saneblidze

Vladimer Chavchanidze Institute of Cybernetics of the Georgian Technical UniversityTbilisi, Georgia
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Saneblidze, Liana
, 
Tamar Tsertsvadze

Tamar Tsertsvadze

Ivane Javakhishvili Tbilisi State UniversityTbilisi, Georgia
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Tsertsvadze, Tamar
, 
Nino Maisuradze

Nino Maisuradze

Ivane Javakhishvili Tbilisi State UniversityTbilisi, Georgia
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Maisuradze, Nino
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Nino Leladze

Nino Leladze

Ivane Javakhishvili Tbilisi State UniversityTbilisi, Georgia
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Leladze, Nino
 and 
Manfred Kriechbaum

Manfred Kriechbaum

Institute of Inorganic Chemistry, Graz University of TechnologyGraz, Austria
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Kriechbaum, Manfred
  
Dec 13, 2021
Stable aqueous dispersions of bare and double layer functionalized superparamagnetic iron oxide nanoparticles for biomedical applications's Cover Image
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Published Online: Dec 13, 2021
Page range: 331 - 345
Received: Aug 16, 2021
Accepted: Oct 19, 2021
DOI: https://doi.org/10.2478/msp-2021-0028
Keywords
© 2021 Jano Markhulia et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig. 1

The Zeta-potential and size distribution of particle agglomerates in the synthesized samples. BIONs, bare iron oxide nanoparticles; OA, oleic acid; PEGMO, poly(ethylene) glycol monooleate; SPIONs, superpara-magnetic iron oxide nanoparticles.
The Zeta-potential and size distribution of particle agglomerates in the synthesized samples. BIONs, bare iron oxide nanoparticles; OA, oleic acid; PEGMO, poly(ethylene) glycol monooleate; SPIONs, superpara-magnetic iron oxide nanoparticles.

Fig. 2

Schematic representation of charges on the surface of magnetite nanoparticles as a function of pH. ZPC, zero-point charge.
Schematic representation of charges on the surface of magnetite nanoparticles as a function of pH. ZPC, zero-point charge.

Fig. 3

Schematic depiction of the stabilization of Fe3O4 nanoparticles in water. OA, oleic acid; PEGMO, poly(ethylene) glycol monooleate; SPION, superparamagnetic iron oxide nanoparticles.
Schematic depiction of the stabilization of Fe3O4 nanoparticles in water. OA, oleic acid; PEGMO, poly(ethylene) glycol monooleate; SPION, superparamagnetic iron oxide nanoparticles.

Fig. 4

Diffractograms of synthesized specimens taken with Fe Kα anode (λ = 1.937283 Å) (a), the same diffractograms converted to Cu Kα radiation (λ = 1.54178 Å) (b). BIONs, bare iron oxide nanoparticles; OA, oleic acid; PEGMO, poly(ethylene) glycol monooleate; SPIONs, superparamagnetic iron oxide nanoparticles.
Diffractograms of synthesized specimens taken with Fe Kα anode (λ = 1.937283 Å) (a), the same diffractograms converted to Cu Kα radiation (λ = 1.54178 Å) (b). BIONs, bare iron oxide nanoparticles; OA, oleic acid; PEGMO, poly(ethylene) glycol monooleate; SPIONs, superparamagnetic iron oxide nanoparticles.

Fig. 5

Guinier plots for evaluating radius of gyration Rg for the colloid dispersions (the fitting of the reference model (red line) to experimental SAXS data (grey, blue, green). BIONs, bare iron oxide nanoparticles; OA, oleic acid; PEGMO, poly(ethylene) glycol monooleate; SPIONs, superparamagnetic iron oxide nanoparticles.
Guinier plots for evaluating radius of gyration Rg for the colloid dispersions (the fitting of the reference model (red line) to experimental SAXS data (grey, blue, green). BIONs, bare iron oxide nanoparticles; OA, oleic acid; PEGMO, poly(ethylene) glycol monooleate; SPIONs, superparamagnetic iron oxide nanoparticles.

Fig. 6

McSAS fitting for evaluating size distribution and pair-distance distribution function p(r) obtained by GNOM. BIONs, bare iron oxide nanoparticles; OA, oleic acid; PEGMO, poly(ethylene) glycol monooleate; SPIONs, superparamagnetic iron oxide nanoparticles.
McSAS fitting for evaluating size distribution and pair-distance distribution function p(r) obtained by GNOM. BIONs, bare iron oxide nanoparticles; OA, oleic acid; PEGMO, poly(ethylene) glycol monooleate; SPIONs, superparamagnetic iron oxide nanoparticles.

Fig. 7

Particle size distributions obtained using McSAS. BIONs, bare iron oxide nanoparticles; OA, oleic acid; PEGMO, poly(ethylene) glycol monooleate; SPIONs, superparamagnetic iron oxide nanoparticles.
Particle size distributions obtained using McSAS. BIONs, bare iron oxide nanoparticles; OA, oleic acid; PEGMO, poly(ethylene) glycol monooleate; SPIONs, superparamagnetic iron oxide nanoparticles.

Fig. 8

Ab initio SAXS models of bare, OA-SPIONs, PEGMO460-OA-SPIONs, and PEGMO860-OA-SPIONs nanoparticles constructed using DAMMIN. OA, oleic acid; PEGMO, poly(ethylene) glycol monooleate; SAXS, small-angle X-ray scattering; SPIONs, superparamagnetic iron oxide nanoparticles.
Ab initio SAXS models of bare, OA-SPIONs, PEGMO460-OA-SPIONs, and PEGMO860-OA-SPIONs nanoparticles constructed using DAMMIN. OA, oleic acid; PEGMO, poly(ethylene) glycol monooleate; SAXS, small-angle X-ray scattering; SPIONs, superparamagnetic iron oxide nanoparticles.

Fig. 9

Magnetization curves of synthesized samples at a temperature of 300 K. BIONs, bare iron oxide nanoparticles; OA, oleic acid; PEGMO, poly(ethylene) glycol monooleate; SPIONs, superparamagnetic iron oxide nanoparticles.
Magnetization curves of synthesized samples at a temperature of 300 K. BIONs, bare iron oxide nanoparticles; OA, oleic acid; PEGMO, poly(ethylene) glycol monooleate; SPIONs, superparamagnetic iron oxide nanoparticles.

Fig. 10

FTIR spectra of pure OA, PEGMO460, and PEGMO860 in liquid form (left); FTIR spectra of BIONs, PEG460-OA-SPIONs, and PEG860-OA-SPIONs samples (right). BIONs, bare iron oxide nanoparticles; FTIR, fourier-transform infrared spectroscopy; OA, oleic acid; PEGMO, poly(ethylene) glycol monooleate; SPIONs, superparamagnetic iron oxide nanoparticles.
FTIR spectra of pure OA, PEGMO460, and PEGMO860 in liquid form (left); FTIR spectra of BIONs, PEG460-OA-SPIONs, and PEG860-OA-SPIONs samples (right). BIONs, bare iron oxide nanoparticles; FTIR, fourier-transform infrared spectroscopy; OA, oleic acid; PEGMO, poly(ethylene) glycol monooleate; SPIONs, superparamagnetic iron oxide nanoparticles.

Nanoparticles average size obtained by SAXS measurement_

Sample Average radius of nanoparticles obtained by SAXS (nm)
BIONs 14.6
OA–SPIONs 15.8
PEGMO460–OA–SPIONs 14.0
PEGMO860–OA–SPIONs 15.5

Saturation magnetization of the samples_

Samples Saturation magnetization Ms (emu/g)
BIONs (Fe3O4) 64.6 (Ha = 1.07 T)
OA-SPIONs 51.1 (Ha = 1.07 T)
PEGMO460-OA-SPIONs 39.0 (Ha = 1.00 T)
PEGMO860-OA-SPIONs 48.9 (Ha = 1.07 T)

ELS and DLS Experimental results of samples_

Samples Measurement temperature °C Mean value of potential (mV) Hydrodynamic diameter (nm) Polydispersity index (%)
BIONs 20 21.7 225 20.6
OA-SPIONs 20 −24.2 182 22.0
PEGMO860-OA-SPIONs 20 −23.3 101 19.5
PEGMO460-OA-SPIONs 20 −34.5 110 23.2

Average crystallite size of the samples calculated by Scherrer formula_

Sample Average size of crystallite estimated by XRD (Fe Kα; λ = 1.937Å) (nm) Crystalline lattice parameter (Å)
BIONs 20.0 8.3755
OA–SPIONs 21.8 8.3755
PEGMO460–OA–SPIONs 21.0 8.3725
PEGMO860–OA–SPIONs 23.1 8.3725
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Materials Sciences, Materials Sciences, other, Nanomaterials, Functional and Smart Materials, Materials Characterization and Properties
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