<abstract xmlns="http://www.w3.org/1999/xhtml"><p>A 14-d study was undertaken to test the acute toxicity of a new preparation Vetom 21.77 based on the predacious fungus <italic>Duddingtonia flagrans</italic>. A total of 40 healthy 5-day-old broiler chickens (Hubbard F15, 100 ± 5 g), that had previously gone through a required 5-days adaptation to the environment, were orally dosed with the drug for 5 consecutive days at different doses, after which their health status was assessed daily up to the end of the experiment. According to the results, no substantial changes in the physiological state of the chickens were detected during the experiment. Internal organs weighing revealed no statistically significant differences between the groups, though weight coefficient values of internal organs of treated chickens slightly exceeded those of the control group. Some haematological parameters were significantly higher in the treatment group, without going beyond reference ranges. All chickens used in the experiment survived the study. The preparation has not produced any toxic effect even at a higher dose (4000 µL/kg bw/day). It is concluded that Vetom 21.77 pertains to preparations of IV toxicity class.</p></abstract>

A 14-d study was undertaken to test the acute toxicity of a new preparation Vetom 21.77 based on the predacious fungus Duddingtonia flagrans. A total of 40 healthy 5-day-old broiler chickens (Hubbard F15, 100 ± 5 g), that had previously gone through a required 5-days adaptation to the environment, were orally dosed with the drug for 5 consecutive days at different doses, after which their health status was assessed daily up to the end of the experiment. According to the results, no substantial changes in the physiological state of the chickens were detected during the experiment. Internal organs weighing revealed no statistically significant differences between the groups, though weight coefficient values of internal organs of treated chickens slightly exceeded those of the control group. Some haematological parameters were significantly higher in the treatment group, without going beyond reference ranges. All chickens used in the experiment survived the study. The preparation has not produced any toxic effect even at a higher dose (4000 µL/kg bw/day). It is concluded that Vetom 21.77 pertains to preparations of IV toxicity class.

Acute Oral Toxicity of Vetom 21.77 Based on <italic>Duddingtonia Flagrans</italic> in Broiler Chickens

Department of Pharmacology and General Pathology, Faculty of Veterinary Medicine

Macedonian Veterinary Review

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Acute Oral Toxicity of Vetom 21.77 Based on  in Broiler Chickens

A 14-d study was undertaken to test the acute toxicity of a new preparation Vetom 21.77 based on the predacious fungus Duddingtonia flagrans. A total of 40...

Acute Oral Toxicity of Vetom 21.77 Based on Duddingtonia Flagrans in Broiler Chickens

Published Online: Mar 28, 2019

Page range: 87 - 93

Received: Mar 02, 2018

Accepted: Sep 18, 2018

DOI: https://doi.org/10.2478/macvetrev-2018-0031

Keywords
Vetom 21.77, acute toxicity, Hubbard F15

© 2018 Elmira R. Rafikova, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Acute Oral Toxicity of Vetom 21.77 Based on Duddingtonia Flagrans in Broiler Chickens

Published Online: Mar 28, 2019

Page range: 87 - 93

Received: Mar 02, 2018

Accepted: Sep 18, 2018

DOI: https://doi.org/10.2478/macvetrev-2018-0031

KeywordsVetom 21.77, acute toxicity, Hubbard F15

© 2018 Elmira R. Rafikova, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
Vetom 21.77, acute toxicity, Hubbard F15