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Spontaneous alteration of blood pH by a bicarbonate buffer system during experimental hypercalcaemia in cows

Younghye Ro
Younghye Ro
, 
Woojae Choi
Woojae Choi
, 
Leegon Hong
Leegon Hong
, 
Eunkyung Kim
Eunkyung Kim
, 
Eunhui Choe
Eunhui Choe
 and 
Danil Kim
Danil Kim
   | Oct 01, 2021
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Article Category: Review article
Published Online: Oct 01, 2021
Page range: 539 - 543
Received: Mar 17, 2021
Accepted: Sep 23, 2021
DOI: https://doi.org/10.2478/jvetres-2021-0053
Keywords
© 2021 Y. Ro et al. published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Fig 1

Changes in plasma mineral concentrations, urinary mineral excretions, and blood gas parameters in the control group (CON) and induced hypercalcaemic group (HYC)A – Ca concentration in plasma; B – Ca excretion through urine (Ca/creatine (crea)); C – Mg concentration in plasma; D – Mg excretion through urine (Mg/crea); E – blood pH; F – bicarbonate (HCO3−); G – partial pressure of carbon dioxide (pCO2); H – ionised Ca. Data are expressed as means ± standard deviation. * – significant difference compared to 0h (P < 0.05); ** – significant difference compared to 0 h (P < 0.001); a – significant difference compared to CON (P < 0.05); b – significant difference compared to CON (P < 0.001)
Changes in plasma mineral concentrations, urinary mineral excretions, and blood gas parameters in the control group (CON) and induced hypercalcaemic group (HYC)A – Ca concentration in plasma; B – Ca excretion through urine (Ca/creatine (crea)); C – Mg concentration in plasma; D – Mg excretion through urine (Mg/crea); E – blood pH; F – bicarbonate (HCO3−); G – partial pressure of carbon dioxide (pCO2); H – ionised Ca. Data are expressed as means ± standard deviation. * – significant difference compared to 0h (P < 0.05); ** – significant difference compared to 0 h (P < 0.001); a – significant difference compared to CON (P < 0.05); b – significant difference compared to CON (P < 0.001)

Results of Pearson correlation analysis of Ca concentration with pH in the induced hypercalcaemic group

Test (n) iCa Ca/crea pH HCO3− pCO2
Ca r value 0.933 0.846 0.688 0.672 0.206
(P value) 45 (<0.001)** (<0.001)** (<0.001)** (<0.001)** (0.174)
iCa r value 45 0.860 0.542 0.549 0.194
(P value) (<0.001)** (<0.001)** (<0.001)** (0.201)
Ca/crea r value 0.511 0.486 0.125
(P value) 45 (<0.001)** (<0.001)** (0.412)
pH r value 45 0.820 0.041
(P value) (<0.001)** (0.788)
HCO3- r value 0.603
(P value) 45 (<0.001)**

Results of Pearson correlation analysis of parameters in blood analyses in all individuals

Test (n) Mg Ca/crea Mg/crea iCa pH HCO3− pCO2
Ca r value 0.599 0.825 0.698 0.917 0.466 0.490 0.220
(P value) 90 (<0.001)** (<0.001)** (<0.001)** (<0.001)** (<0.001)** (<0.001)** (0.037)*
Mg r value 0.381 0.438 0.410 0.340 0.262 0.004
(P value) 90 (<0.001)** (<0.001)** (<0.001)** (0.001)* (0.013)* (0.971)
Ca/crea r value 0.891 0.857 0.370 0.382 0.161
(P value) 90 (<0.001)** (<0.001)** (<0.001)** (<0.001)** (0.131)
Mg/crea r value 0.712 0.345 0.380 0.181
(P value) 90 (<0.001)** (<0.001)** (<0.001)** (0.088)
iCa r value 0.309 0.348 0.175
(P value) 90 (0.003)* (<0.001)** (0.098)
pH r value 0.781 0.085
(P value) 90 (<0.001)** (0.424)
− HCO3 r value 0.687
(P value) 90 (<0.001)**
eISSN:
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Language:
English
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Journal Subjects:
Life Sciences, Molecular Biology, Microbiology and Virology, other, Medicine, Veterinary Medicine
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