<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec id="j_jvetres-2021-0002_s_005"><h3>Introduction</h3>
<p>The purpose of this study was to determine the effects of vitamin C supplementation on blood oxidative stress biomarkers and antibody response to vaccination in calves.</p></sec>
<sec id="j_jvetres-2021-0002_s_006"><h3>Material and methods</h3>
<p>Thirty-four clinically healthy 2 week old Japanese Black calves were randomly assigned to two groups. Seventeen calves formed the VC group which received 1,000 mg of vitamin C daily from 2 to 8 weeks of age, and the other 17 calves of the control group did not receive supplementation. All calves received an inactivated <italic>Histophilus somni</italic> vaccine at 4 and 8 weeks of age. Blood samples were taken at 2, 4, 8 and 12 weeks of age.</p></sec>
<sec id="j_jvetres-2021-0002_s_007"><h3>Results</h3>
<p>The concentration of the serum reactive oxygen metabolites (d-ROMs), and the oxidative stress index (OSI), which is calculated from the d-ROMs and biological antioxidant potential, were significantly lower at 8 weeks of age in the VC group than in the control group (P &lt; 0.05). The antibody titres to <italic>H. somni</italic> in the VC group were significantly higher than those in the control group at 12 weeks of age after the second vaccination (P &lt; 0.05).</p></sec>
<sec id="j_jvetres-2021-0002_s_008"><h3>Conclusion</h3>
<p>Vitamin C supplementation to calves may reduce oxidative stress and enhance the antibody production after vaccination with <italic>H. somni</italic>.</p></sec></abstract>

Introduction
The purpose of this study was to determine the effects of vitamin C supplementation on blood oxidative stress biomarkers and antibody response to vaccination in calves.
Material and methods
Thirty-four clinically healthy 2 week old Japanese Black calves were randomly assigned to two groups. Seventeen calves formed the VC group which received 1,000 mg of vitamin C daily from 2 to 8 weeks of age, and the other 17 calves of the control group did not receive supplementation. All calves received an inactivated Histophilus somni vaccine at 4 and 8 weeks of age. Blood samples were taken at 2, 4, 8 and 12 weeks of age.
Results
The concentration of the serum reactive oxygen metabolites (d-ROMs), and the oxidative stress index (OSI), which is calculated from the d-ROMs and biological antioxidant potential, were significantly lower at 8 weeks of age in the VC group than in the control group (P < 0.05). The antibody titres to H. somni in the VC group were significantly higher than those in the control group at 12 weeks of age after the second vaccination (P < 0.05).
Conclusion
Vitamin C supplementation to calves may reduce oxidative stress and enhance the antibody production after vaccination with H. somni.

Effects of vitamin C supplementation on the blood oxidative stress and antibody titre against <italic>Histophilus somni</italic> vaccination in calves

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Effects of vitamin C supplementation on the blood oxidative stress and antibody titre against  vaccination in calves

Introduction
The purpose of this study was to determine the effects of vitamin C supplementation on blood oxidative stress biomarkers and antibody response to...

Effects of vitamin C supplementation on the blood oxidative stress and antibody titre against Histophilus somni vaccination in calves

Published Online: Dec 29, 2020

Page range: 73 - 78

Received: Jul 06, 2020

Accepted: Dec 07, 2020

DOI: https://doi.org/10.2478/jvetres-2021-0002

Keywords
calves, oxidative stress, vaccination, vitamin C

© 2021 K. Otomaru et al. published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Effects of vitamin C supplementation on the blood oxidative stress and antibody titre against Histophilus somni vaccination in calves

Published Online: Dec 29, 2020

Page range: 73 - 78

Received: Jul 06, 2020

Accepted: Dec 07, 2020

DOI: https://doi.org/10.2478/jvetres-2021-0002

Keywordscalves, oxidative stress, vaccination, vitamin C

© 2021 K. Otomaru et al. published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
calves, oxidative stress, vaccination, vitamin C