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Xylazine regulates the release of glycine and aspartic acid in rat brain

Yi-Ming Zhang

Yi-Ming Zhang

College of Veterinary Medicine, Northeast Agricultural UniversityHarbin, China
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Zhang, Yi-Ming
, 
Dong-Xu Yu

Dong-Xu Yu

College of Veterinary Medicine, Northeast Agricultural UniversityHarbin, China
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Yu, Dong-Xu
, 
Bai-Shuang Yin

Bai-Shuang Yin

College of Veterinary Medicine, Northeast Agricultural UniversityHarbin, China
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Yin, Bai-Shuang
, 
Xin-Ran Li

Xin-Ran Li

College of Veterinary Medicine, Northeast Agricultural UniversityHarbin, China
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Li, Xin-Ran
, 
Li-Na Li

Li-Na Li

College of Veterinary Medicine, Northeast Agricultural UniversityHarbin, China
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Li, Li-Na
, 
Ya-Nan Li

Ya-Nan Li

College of Veterinary Medicine, Northeast Agricultural UniversityHarbin, China
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Li, Ya-Nan
, 
Yu-Xin Wang

Yu-Xin Wang

College of Veterinary Medicine, Northeast Agricultural UniversityHarbin, China
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Wang, Yu-Xin
, 
Yu Chen

Yu Chen

College of Veterinary Medicine, Northeast Agricultural UniversityHarbin, China
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Chen, Yu
, 
Wen-Han Liu

Wen-Han Liu

College of Veterinary Medicine, Northeast Agricultural UniversityHarbin, China
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Liu, Wen-Han
 and 
Li Gao

Li Gao

College of Veterinary Medicine, Northeast Agricultural UniversityHarbin, China
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Gao, Li
  
Mar 30, 2018
Xylazine regulates the release of glycine and aspartic acid in rat brain's Cover Image
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Published Online: Mar 30, 2018
Page range: 121 - 128
Received: Sep 15, 2017
Accepted: Feb 14, 2018
DOI: https://doi.org/10.2478/jvetres-2018-0017
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© 2018 Y.-M. Zhang et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Fig. 1

The effect of low-dose xylazine anaesthesia on Gly neurotransmitters in rat brain. C – control group, I – induction period, A – anaesthesia period, R1 – recovery period (group R1), R2 – recovery period (group R2), R3 – recovery period ( group R3). ∗P < 0.05; ∗∗P < 0.01
The effect of low-dose xylazine anaesthesia on Gly neurotransmitters in rat brain. C – control group, I – induction period, A – anaesthesia period, R1 – recovery period (group R1), R2 – recovery period (group R2), R3 – recovery period ( group R3). ∗P < 0.05; ∗∗P < 0.01

Fig. 2

The effect of low-dose xylazine anaesthesia on Asp neurotransmitters in rat brain. C – control group, I – induction period, A – anaesthesia period, R1 – recovery period (group R1), R2 – recovery period (group R2), R3 – recovery period (group R3). ∗P < 0.05; ∗∗P < 0.01
The effect of low-dose xylazine anaesthesia on Asp neurotransmitters in rat brain. C – control group, I – induction period, A – anaesthesia period, R1 – recovery period (group R1), R2 – recovery period (group R2), R3 – recovery period (group R3). ∗P < 0.05; ∗∗P < 0.01

Fig. 3

The effect of high-dose xylazine anaesthesia on Gly neurotransmitters in rat brain. C – control group, I – induction period, A – anaesthesia period, R1 – recovery period (group R1), R2 – recovery period (group R2), R3 – recovery period (group R3). ∗P < 0.05; ∗∗P < 0.01
The effect of high-dose xylazine anaesthesia on Gly neurotransmitters in rat brain. C – control group, I – induction period, A – anaesthesia period, R1 – recovery period (group R1), R2 – recovery period (group R2), R3 – recovery period (group R3). ∗P < 0.05; ∗∗P < 0.01

Fig. 4

The effect of high-dose xylazine anaesthesia on Asp neurotransmitters in rat brain. C – control group, I – induction period, A – anaesthesia period, R1 – recovery period (group R1), R2 – recovery period ( group R2), R3 – recovery period (group R3). ∗P < 0.05; ∗∗P < 0.01
The effect of high-dose xylazine anaesthesia on Asp neurotransmitters in rat brain. C – control group, I – induction period, A – anaesthesia period, R1 – recovery period (group R1), R2 – recovery period ( group R2), R3 – recovery period (group R3). ∗P < 0.05; ∗∗P < 0.01

Fig. 5

Effects of different concentrations of xylazine on neurons secreting the neurotransmitter Gly. At 5, 10, 15, 20, 25, 30, 45, 60, 90, and 120 min xylazine was allowed to act on the neurons. (A) 15 μg/mL xylazine, (B) 25 μg/mL xylazine, (C) 35 μg/mL xylazine, (D) 45 μg/mL xylazine. ∗P < 0.05; ∗∗P < 0.01 versus control, #P < 0.05; ##P < 0.01 versus the minimum value
Effects of different concentrations of xylazine on neurons secreting the neurotransmitter Gly. At 5, 10, 15, 20, 25, 30, 45, 60, 90, and 120 min xylazine was allowed to act on the neurons. (A) 15 μg/mL xylazine, (B) 25 μg/mL xylazine, (C) 35 μg/mL xylazine, (D) 45 μg/mL xylazine. ∗P < 0.05; ∗∗P < 0.01 versus control, #P < 0.05; ##P < 0.01 versus the minimum value

Fig. 6

Effects of different concentrations of xylazine on neurons secreting the neurotransmitter Asp. At 5, 10, 15, 20, 25, 30, 45, 60, 90, and 120 min xylazine was allowed to act on the neurons. (A) 15 μg/mL xylazine, (B) 25 μg/mL xylazine, (C) 35 μg/mL xylazine, (D) 45 μg/mL xylazine. ∗P < 0.05; ∗∗P < 0.01 versus control, #P < 0.05; ##P < 0.01 versus the minimum value
Effects of different concentrations of xylazine on neurons secreting the neurotransmitter Asp. At 5, 10, 15, 20, 25, 30, 45, 60, 90, and 120 min xylazine was allowed to act on the neurons. (A) 15 μg/mL xylazine, (B) 25 μg/mL xylazine, (C) 35 μg/mL xylazine, (D) 45 μg/mL xylazine. ∗P < 0.05; ∗∗P < 0.01 versus control, #P < 0.05; ##P < 0.01 versus the minimum value
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