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Xylazine regulates the release of glycine and aspartic acid in rat brain

Yi-Ming Zhang
Yi-Ming Zhang
, 
Dong-Xu Yu
Dong-Xu Yu
, 
Bai-Shuang Yin
Bai-Shuang Yin
, 
Xin-Ran Li
Xin-Ran Li
, 
Li-Na Li
Li-Na Li
, 
Ya-Nan Li
Ya-Nan Li
, 
Yu-Xin Wang
Yu-Xin Wang
, 
Yu Chen
Yu Chen
, 
Wen-Han Liu
Wen-Han Liu
 y 
Li Gao
Li Gao
   | 30 mar 2018
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Publicado en línea: 30 mar 2018
Páginas: 121 - 128
Recibido: 15 sept 2017
Aceptado: 14 feb 2018
DOI: https://doi.org/10.2478/jvetres-2018-0017
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© 2018 Y.-M. Zhang et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Fig. 1

The effect of low-dose xylazine anaesthesia on Gly neurotransmitters in rat brain. C – control group, I – induction period, A – anaesthesia period, R1 – recovery period (group R1), R2 – recovery period (group R2), R3 – recovery period ( group R3). ∗P < 0.05; ∗∗P < 0.01
The effect of low-dose xylazine anaesthesia on Gly neurotransmitters in rat brain. C – control group, I – induction period, A – anaesthesia period, R1 – recovery period (group R1), R2 – recovery period (group R2), R3 – recovery period ( group R3). ∗P < 0.05; ∗∗P < 0.01

Fig. 2

The effect of low-dose xylazine anaesthesia on Asp neurotransmitters in rat brain. C – control group, I – induction period, A – anaesthesia period, R1 – recovery period (group R1), R2 – recovery period (group R2), R3 – recovery period (group R3). ∗P < 0.05; ∗∗P < 0.01
The effect of low-dose xylazine anaesthesia on Asp neurotransmitters in rat brain. C – control group, I – induction period, A – anaesthesia period, R1 – recovery period (group R1), R2 – recovery period (group R2), R3 – recovery period (group R3). ∗P < 0.05; ∗∗P < 0.01

Fig. 3

The effect of high-dose xylazine anaesthesia on Gly neurotransmitters in rat brain. C – control group, I – induction period, A – anaesthesia period, R1 – recovery period (group R1), R2 – recovery period (group R2), R3 – recovery period (group R3). ∗P < 0.05; ∗∗P < 0.01
The effect of high-dose xylazine anaesthesia on Gly neurotransmitters in rat brain. C – control group, I – induction period, A – anaesthesia period, R1 – recovery period (group R1), R2 – recovery period (group R2), R3 – recovery period (group R3). ∗P < 0.05; ∗∗P < 0.01

Fig. 4

The effect of high-dose xylazine anaesthesia on Asp neurotransmitters in rat brain. C – control group, I – induction period, A – anaesthesia period, R1 – recovery period (group R1), R2 – recovery period ( group R2), R3 – recovery period (group R3). ∗P < 0.05; ∗∗P < 0.01
The effect of high-dose xylazine anaesthesia on Asp neurotransmitters in rat brain. C – control group, I – induction period, A – anaesthesia period, R1 – recovery period (group R1), R2 – recovery period ( group R2), R3 – recovery period (group R3). ∗P < 0.05; ∗∗P < 0.01

Fig. 5

Effects of different concentrations of xylazine on neurons secreting the neurotransmitter Gly. At 5, 10, 15, 20, 25, 30, 45, 60, 90, and 120 min xylazine was allowed to act on the neurons. (A) 15 μg/mL xylazine, (B) 25 μg/mL xylazine, (C) 35 μg/mL xylazine, (D) 45 μg/mL xylazine. ∗P < 0.05; ∗∗P < 0.01 versus control, #P < 0.05; ##P < 0.01 versus the minimum value
Effects of different concentrations of xylazine on neurons secreting the neurotransmitter Gly. At 5, 10, 15, 20, 25, 30, 45, 60, 90, and 120 min xylazine was allowed to act on the neurons. (A) 15 μg/mL xylazine, (B) 25 μg/mL xylazine, (C) 35 μg/mL xylazine, (D) 45 μg/mL xylazine. ∗P < 0.05; ∗∗P < 0.01 versus control, #P < 0.05; ##P < 0.01 versus the minimum value

Fig. 6

Effects of different concentrations of xylazine on neurons secreting the neurotransmitter Asp. At 5, 10, 15, 20, 25, 30, 45, 60, 90, and 120 min xylazine was allowed to act on the neurons. (A) 15 μg/mL xylazine, (B) 25 μg/mL xylazine, (C) 35 μg/mL xylazine, (D) 45 μg/mL xylazine. ∗P < 0.05; ∗∗P < 0.01 versus control, #P < 0.05; ##P < 0.01 versus the minimum value
Effects of different concentrations of xylazine on neurons secreting the neurotransmitter Asp. At 5, 10, 15, 20, 25, 30, 45, 60, 90, and 120 min xylazine was allowed to act on the neurons. (A) 15 μg/mL xylazine, (B) 25 μg/mL xylazine, (C) 35 μg/mL xylazine, (D) 45 μg/mL xylazine. ∗P < 0.05; ∗∗P < 0.01 versus control, #P < 0.05; ##P < 0.01 versus the minimum value
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