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The use of ibuprofen as an anti-seizure medication: a systematic review

Ariel Tristan

Ariel Tristan

Department of Medicine, Faculty of Medicine, Universitas Diponegoro Semarang Indonesia
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Tristan, Ariel
, 
Noor Wijayahadi

Noor Wijayahadi

Department of Pharmacology, Faculty of Medicine, Universitas Diponegoro Semarang Indonesia
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Wijayahadi, Noor
, 
Tri Nur Kristina

Tri Nur Kristina

Department of Microbiology, Faculty of Medicine, Universitas Diponegoro Semarang Indonesia
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Kristina, Tri Nur
 and 
Santoso Jaeri

Santoso Jaeri

  • Department of Medical Biology & Biochemistry, Faculty of Medicine, Universitas Diponegoro Semarang Indonesia
  • Department of Neurology, Diponegoro National Hospital, Universitas Diponegoro Semarang Indonesia
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Jaeri, Santoso
  
May 22, 2024
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Article Category: Review paper
Published Online: May 22, 2024
Page range: 3 - 8
Received: Mar 01, 2024
Accepted: Apr 29, 2024
DOI: https://doi.org/10.2478/joepi-2024-0001
Keywords
© 2024 Ariel Tristan et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1.

PRISMA Flow Diagram.
PRISMA Flow Diagram.

Figure 2.

Summary of SYRCLE Risk of Bias Tool assessment.
Summary of SYRCLE Risk of Bias Tool assessment.

Summary of article selection results

No. Author, year Design Samples Intervention Induction Results
1. Durankus et al., 2020 Experimental 48 male Sprague-Dawley rats 200 mg/kg and 400 mg/kg ibuprofen injection intraperitoneally 30 minutes before disease induction Pentylenetetrazole 35 mg/kg intraperitoneally Reduced spike percentage in EEG, Racine Convulsion Score and low first myoclonic jerk
2. Peng et al., 2019 Experimental 60 male Sprague-Dawley rats 30 mg/kg ibuprofen injection intraperitoneally 30 minutes before disease induction Pentylenetetrazole 35 mg/kg intraperitoneally Reduced, number, grade, latency, shortened duration of seizures and number of small amplitude spikes and spine slow waves in EEG
3. Liu et al., 2020 Experimental 64 male Sprague-Dawley rats 30 mg/kg ibuprofen injection intraperitoneally 30 minutes before disease nduction Pentylenetetrazole 35 mg/kg intraperitoneally Reduced frequency, latency and duration of seizures
Language:
English
Publication timeframe:
2 times per year
Journal Subjects:
Medicine, Clinical Medicine, Clinical Medicine, other, Neurology, Pharmacology, Toxicology, Pharmacy, Clinical Pharmacy
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