The use of ibuprofen as an anti-seizure medication: a systematic review

No.	Author, year	Design	Samples	Intervention	Induction	Results
1.	Durankus et al., 2020	Experimental	48 male Sprague-Dawley rats	200 mg/kg and 400 mg/kg ibuprofen injection intraperitoneally 30 minutes before disease induction	Pentylenetetrazole 35 mg/kg intraperitoneally	Reduced spike percentage in EEG, Racine Convulsion Score and low first myoclonic jerk
2.	Peng et al., 2019	Experimental	60 male Sprague-Dawley rats	30 mg/kg ibuprofen injection intraperitoneally 30 minutes before disease induction	Pentylenetetrazole 35 mg/kg intraperitoneally	Reduced, number, grade, latency, shortened duration of seizures and number of small amplitude spikes and spine slow waves in EEG
3.	Liu et al., 2020	Experimental	64 male Sprague-Dawley rats	30 mg/kg ibuprofen injection intraperitoneally 30 minutes before disease nduction	Pentylenetetrazole 35 mg/kg intraperitoneally	Reduced frequency, latency and duration of seizures

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Argomenti della rivista:: Medicina, Medicina clinica, Medicina clinica, altro, Neurologia, Farmacologia, Tossicologia, Farmacia, Farmaceutica clinica