Open Access

Early thrombus detection in ECMO with optimized impedance measurements: A simulative study

, ,  and   
Jul 01, 2025

Cite
Download Cover

Brodie D, Slutsky AS, and Combes A. Extracorporeal Life Support for Adults With Respiratory Failure and Related Indications: A Review. JAMA 2019 Aug; 322:557. DOI: 10.1001/jama.2019.9302 Brodie D Slutsky AS Combes A Extracorporeal Life Support for Adults With Respiratory Failure and Related Indications: A Review JAMA. 2019 Aug 322 557 10.1001/jama.2019.9302 Open DOISearch in Google Scholar

Teijeiro-Paradis R, Gannon WD, and Fan E. Complications Associated With Venovenous Extracorporeal Membrane Oxygenation—What Can Go Wrong? Critical Care Medicine 2022 Sep; 50:1809–18. DOI: 10.1097/CCM.0000000000005673 Teijeiro-Paradis R Gannon WD Fan E Complications Associated With Venovenous Extracorporeal Membrane Oxygenation—What Can Go Wrong? Critical Care Medicine 2022 Sep 50 1809 18 10.1097/CCM.0000000000005673 Open DOISearch in Google Scholar

Iannattone PA, Yang SS, Koolian M, Wong EG, and Lipes J. Incidence of Venous Thromboembolism in Adults Receiving Extracorporeal Membrane Oxygenation: A Systematic Review. ASAIO Journal 2022 Mar; 68:1523–8. DOI: 10.1097/MAT.0000000000001694 Iannattone PA Yang SS Koolian M Wong EG Lipes J Incidence of Venous Thromboembolism in Adults Receiving Extracorporeal Membrane Oxygenation: A Systematic Review ASAIO Journal 2022 Mar 68 1523 8 10.1097/MAT.0000000000001694 Open DOISearch in Google Scholar

Dornia C, Philipp A, Bauer S, Lubnow M, Müller T, Lehle K, Schmid C, Müller-Wille R, Wiggermann P, Stroszczynski C, and Schreyer AG. Analysis of Thrombotic Deposits in Extracorporeal Membrane Oxygenators by Multidetector Computed Tomography. ASAIO Journal 2014 Nov; 60:652–6. DOI: 10.1097/MAT.0000000000000133 Dornia C Philipp A Bauer S Lubnow M Müller T Lehle K Schmid C Müller-Wille R Wiggermann P Stroszczynski C Schreyer AG Analysis of Thrombotic Deposits in Extracorporeal Membrane Oxygenators by Multidetector Computed Tomography ASAIO Journal 2014 Nov 60 652 6 10.1097/MAT.0000000000000133 Open DOISearch in Google Scholar

Türkmen M, Lauwigi T, Fechter T, Gries F, Fischbach A, Gries T, Rossaint R, Bleilevens C, and Winnersbach P. Bioimpedance Analysis as Early Predictor for Clot Formation Inside a Blood-Perfused Test Chamber: Proof of Concept Using an In Vitro Test-Circuit. Biosensors 2023 Mar; 13:394. DOI: 10.3390/bios13030394 Türkmen M Lauwigi T Fechter T Gries F Fischbach A Gries T Rossaint R Bleilevens C Winnersbach P Bioimpedance Analysis as Early Predictor for Clot Formation Inside a Blood-Perfused Test Chamber: Proof of Concept Using an In Vitro Test-Circuit Biosensors 2023 Mar 13 394 10.3390/bios13030394 Open DOISearch in Google Scholar

Gelfan S and Quigley JP. Conductivity of blood during coagulation. American Journal of Physiology-Legacy Content 1930 Sep; 94:531–4. DOI: ajplegacy.1930.94.3.531 Gelfan S Quigley JP Conductivity of blood during coagulation American Journal of Physiology-Legacy Content 1930 Sep 94 531 4 ajplegacy.1930.94.3.531 Open DOISearch in Google Scholar

Noshiro M, Nebuya S, Fujimaki A, Smallwood R, and Brown B. Frequency characteristics of the electrical conductivity in normal and coagulated blood. IFMBE Proceedings. Springer Berlin Heidelberg, 2007 :70–2. DOI: 10.1007/978-3-540-73841-1_21 Noshiro M Nebuya S Fujimaki A Smallwood R Brown B Frequency characteristics of the electrical conductivity in normal and coagulated blood IFMBE Proceedings Springer Berlin Heidelberg 2007 70 2 10.1007/978-3-540-73841-1_21 Open DOISearch in Google Scholar

Sapkota A, Fuse T, Seki M, Maruyama O, Sugawara M, and Takei M. Application of electrical resistance tomography for thrombus visualization in blood. Flow Measurement and Instrumentation 2015 Dec; 46:334–40. DOI: j.flowmeasinst.2015.06.023 Sapkota A Fuse T Seki M Maruyama O Sugawara M Takei M Application of electrical resistance tomography for thrombus visualization in blood Flow Measurement and Instrumentation 2015 Dec 46 334 40 j.flowmeasinst.2015.06.023 Open DOISearch in Google Scholar

Chen H, Yao J, Yang L, Liu K, Chen B, Li J, and Takei M. Development of a Portable Electrical Impedance Tomography Device for Online Thrombus Detection in Extracorporeal-Circulation Equipment. IEEE Sensors Journal 2021 Feb; 21:3653–9. DOI: 10.1109/JSEN.2020.3022078 Chen H Yao J Yang L Liu K Chen B Li J Takei M Development of a Portable Electrical Impedance Tomography Device for Online Thrombus Detection in Extracorporeal-Circulation Equipment IEEE Sensors Journal 2021 Feb 21 3653 9 10.1109/JSEN.2020.3022078 Open DOISearch in Google Scholar

Hathcock JJ. Flow Effects on Coagulation and Thrombosis. Arteriosclerosis, Thrombosis, and Vascular Biology 2006 Aug; 26:1729–37. DOI: 10.1161/01.ATV.0000229658.76797.30 Hathcock JJ Flow Effects on Coagulation and Thrombosis Arteriosclerosis, Thrombosis, and Vascular Biology 2006 Aug 26 1729 37 10.1161/01.ATV.0000229658.76797.30 Open DOISearch in Google Scholar

Istuk N, Gioia AL, Benchakroun H, Lowery A, Mc-Dermott B, and O’Halloran M. Relationship Between the Conductivity of Human Blood and Blood Counts. IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology 2022 Jun; 6:184–90. DOI: 10.1109/JERM.2021.3130788 Istuk N Gioia AL Benchakroun H Lowery A Mc-Dermott B O’Halloran M Relationship Between the Conductivity of Human Blood and Blood Counts IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology 2022 Jun 6 184 90 10.1109/JERM.2021.3130788 Open DOISearch in Google Scholar

Baumgartner C, Hasgall PA, Di Gennaro F, Neufeld E, Lloyd B, Gosselin MC, Payne D, Klingenböck A, and Kuster N. IT’IS Database for Thermal and Electromagnetic Parameters of Biological Tissues, Version 4.2. 2024 Baumgartner C Hasgall PA Di Gennaro F Neufeld E Lloyd B Gosselin MC Payne D Klingenböck A Kuster N IT’IS Database for Thermal and Electromagnetic Parameters of Biological Tissues, Version 4.2 2024 Search in Google Scholar

Adler A and Lionheart WRB. Uses and abuses of EIDORS: an extensible software base for EIT. Physiological Measurement 2006 Apr; 27:S25–S42. DOI: 10 .1088/0967-3334/27/5/S03 Adler A Lionheart WRB Uses and abuses of EIDORS: an extensible software base for EIT Physiological Measurement 2006 Apr 27 S25 S42 10.1088/0967-3334/27/5/S03 Open DOISearch in Google Scholar

Onsager C, Wang C, Costakis C, Aygen C, Lang L, Lee S van der, and Grayson MA. Sensitivity Analysis for Optimizing Electrical Impedance Tomography Protocols. 2021. DOI: 10.48550/arXiv.2111.01397 Onsager C Wang C Costakis C Aygen C Lang L Lee S van der Grayson MA Sensitivity Analysis for Optimizing Electrical Impedance Tomography Protocols 2021 10.48550/arXiv.2111.01397 Open DOISearch in Google Scholar

Korte J, Lauwigi T, Herzog L, Theißen A, Suchorski K, Strudthoff LJ, Focke J, Jansen SV, Gries T, Rossaint R, Bleilevens C, and Winnersbach P. Prediction of Thrombus Formation within an Oxygenator via Bioimpedance Analysis. Biosensors 2024 Oct; 14:511. DOI: 10.3390/bios14100511 Korte J Lauwigi T Herzog L Theißen A Suchorski K Strudthoff LJ Focke J Jansen SV Gries T Rossaint R Bleilevens C Winnersbach P Prediction of Thrombus Formation within an Oxygenator via Bioimpedance Analysis Biosensors 2024 Oct 14 511 10.3390/bios14100511 Open DOISearch in Google Scholar

Smyl D and Liu D. Optimizing Electrode Positions in 2-D Electrical Impedance Tomography Using Deep Learning. IEEE Transactions on Instrumentation and Measurement 2020 Sep; 69:6030–44. DOI: 10.1109/TIM.2020.2970371 Smyl D Liu D Optimizing Electrode Positions in 2-D Electrical Impedance Tomography Using Deep Learning IEEE Transactions on Instrumentation and Measurement 2020 Sep 69 6030 44 10.1109/TIM.2020.2970371 Open DOISearch in Google Scholar

Silva D, Leonhardt S, and Antink CH. Copula-Based Data Augmentation on a Deep Learning Architecture for Cardiac Sensor Fusion. IEEE Journal of Biomedical and Health Informatics 2021 Jul; 25:2521–32. DOI: 10.1109/JBHI.2020.3040551 Silva D Leonhardt S Antink CH Copula-Based Data Augmentation on a Deep Learning Architecture for Cardiac Sensor Fusion IEEE Journal of Biomedical and Health Informatics 2021 Jul 25 2521 32 10.1109/JBHI.2020.3040551 Open DOISearch in Google Scholar

Rixen J, Blass N, Lyra S, and Leonhardt S. Comparison of Machine Learning Classifiers for the Detection of Breast Cancer in an Electrical Impedance Tomography Setup. Algorithms 2023; 16. DOI: 10.3390/a16110517 Rixen J Blass N Lyra S Leonhardt S Comparison of Machine Learning Classifiers for the Detection of Breast Cancer in an Electrical Impedance Tomography Setup Algorithms 2023 16 10.3390/a16110517 Open DOISearch in Google Scholar