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Occult hepatitis B virus infection in people with haemophilia in South Africa

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Jun 10, 2025

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World Health Organization. Global hepatitis report 2024: Action for access in low-and middle-income countries. April 2024. Available from https://www.who.int/publications/i/item/9789240091672 (accessed May 2025). World Health Organization Global hepatitis report 2024: Action for access in low-and middle-income countries April 2024 Available from https://www.who.int/publications/i/item/9789240091672 (accessed May 2025). Search in Google Scholar

World Health Organization. Hepatitis B. Available from https://www.who.int/en/news-room/fact-sheets/detail/hepatitis-b (accessed May 2025). World Health Organization Hepatitis B Available from https://www.who.int/en/news-room/fact-sheets/detail/hepatitis-b (accessed May 2025). Search in Google Scholar

Zampino R, Boemio A, Sagnelli C, et al. 2015. Hepatitis B virus burden in developing countries. World J Gastroenterol 2015; 21(42):11941. doi: 10.3748/wjg.v21.i42.11941. ZampinoR BoemioA SagnelliC 2015. Hepatitis B virus burden in developing countries World J Gastroenterol 2015 21 42 11941 10.3748/wjg.v21.i42.11941 Open DOISearch in Google Scholar

Schweitzer A, Horn J, Mikolajczyk RT, et al. Estimations of worldwide prevalence of chronic hepatitis B virus infection: A systematic review of data published between 1965 and 2013. Lancet 2015; 386(10003):1546–55. doi: 10.1016/S0140-6736(15)61412-X. SchweitzerA HornJ MikolajczykRT Estimations of worldwide prevalence of chronic hepatitis B virus infection: A systematic review of data published between 1965 and 2013 Lancet 2015 386 10003 1546 55 10.1016/S0140-6736(15)61412-X Open DOISearch in Google Scholar

Kiire C. The epidemiology and prophylaxis of hepatitis B in sub-Saharan Africa: A view from tropical and subtropical Africa. Gut 1996; 38(Suppl 2): S5–12. doi: 10.1136/gut.38.suppl_2.s5. KiireC The epidemiology and prophylaxis of hepatitis B in sub-Saharan Africa: A view from tropical and subtropical Africa Gut 1996 38 Suppl 2 S5 12 10.1136/gut.38.suppl_2.s5 Open DOISearch in Google Scholar

Kew MC. Hepatitis B virus infection: The burden of disease in South Africa. Southern African Journal of Epidemiology and Infection 2008; 23(1): 4–8. doi: 10.1080/10158782.2008.11441293. KewMC Hepatitis B virus infection: The burden of disease in South Africa Southern African Journal of Epidemiology and Infection 2008 23 1 4 8 10.1080/10158782.2008.11441293 Open DOISearch in Google Scholar

Shi Y, Zheng M. Hepatitis B virus persistence and reactivation. BMJ 2020; 370: m2200. doi: https://doi.org/10.1136/bmj.m2200 ShiY ZhengM Hepatitis B virus persistence and reactivation BMJ 2020 370 m2200 doi: https://doi.org/10.1136/bmj.m2200 Search in Google Scholar

Yip TCF, Wong GLH. Current knowledge of occult hepatitis B infection and clinical implications. Semin Liver Dis 2019; 39(2): 249–60. doi: 10.1055/s-0039-1678728. YipTCF WongGLH Current knowledge of occult hepatitis B infection and clinical implications Semin Liver Dis 2019 39 2 249 60 10.1055/s-0039-1678728 Open DOISearch in Google Scholar

Raimondo G, Locarnini S, Pollicino T, et al. Update of the statements on biology and clinical impact of occult hepatitis B virus infection. J Hepatol 2019; 71(2):397–408. doi: 10.1016/j.jhep.2019.03.034 RaimondoG LocarniniS PollicinoT Update of the statements on biology and clinical impact of occult hepatitis B virus infection J Hepatol 2019 71 2 397 408 10.1016/j.jhep.2019.03.034 Open DOISearch in Google Scholar

Ocana S, Casas ML, Buhigas I, Lledo JL. Diagnostic strategy for occult hepatitis B virus infection. World J Gastroenterol 2011; 17(12):1553. doi: 10.3748/wjg.v17.i12.1553. OcanaS CasasML BuhigasI LledoJL Diagnostic strategy for occult hepatitis B virus infection World J Gastroenterol 2011 17 12 1553 10.3748/wjg.v17.i12.1553 Open DOISearch in Google Scholar

Kramvis A. Molecular characteristics and clinical relevance of African genotypes and subgenotypes of hepatitis B virus. S Afr Med J 2018; 108(8):17–21. doi: 10.7196/samj.2018.v108i8.13495. KramvisA Molecular characteristics and clinical relevance of African genotypes and subgenotypes of hepatitis B virus S Afr Med J 2018 108 8 17 21 10.7196/samj.2018.v108i8.13495 Open DOISearch in Google Scholar

Hwang EW, Cheung R. Global epidemiology of hepatitis B virus (HBV) infection. North American Journal of Medicine and Science 2011; 4(1):7–13. Available from https://najms.com/index.php/najms/article/view/499 (accessed May 2025). HwangEW CheungR Global epidemiology of hepatitis B virus (HBV) infection North American Journal of Medicine and Science 2011 4 1 7 13 Available from https://najms.com/index.php/najms/article/view/499 (accessed May 2025). Search in Google Scholar

Im YR, Jagdish R, Leith D, et al. Prevalence of occult hepatitis B virus infection in adults: A systematic review and meta-analysis. Lancet Gastroenterol Hepatol 2022; 7(10): 932–42. doi: 10.1016/S2468-1253(22)00201-1. ImYR JagdishR LeithD Prevalence of occult hepatitis B virus infection in adults: A systematic review and meta-analysis Lancet Gastroenterol Hepatol 2022 7 10 932 42 10.1016/S2468-1253(22)00201-1 Open DOISearch in Google Scholar

Weusten J, Van Drimmelen H, Vermeulen M, Lelie N. A mathematical model for estimating residual transmission risk of occult hepatitis B virus infection with different blood safety scenarios. Transfusion 2017; 57(3pt2): 841–9. doi: 10.1111/trf.14050. WeustenJ Van DrimmelenH VermeulenM LelieN A mathematical model for estimating residual transmission risk of occult hepatitis B virus infection with different blood safety scenarios Transfusion 2017 57 3pt2 841 9 10.1111/trf.14050 Open DOISearch in Google Scholar

Candotti D, Boizeau L, Laperche S. Occult hepatitis B infection and transfusion-transmission risk. Transfus Clin Biol 2017; 24(3): 189–95. doi: 10.1016/j.tracli.2017.06.014. CandottiD BoizeauL LapercheS Occult hepatitis B infection and transfusion-transmission risk Transfus Clin Biol 2017 24 3 189 95 10.1016/j.tracli.2017.06.014 Open DOISearch in Google Scholar

Makris M, Preston F, Triger D, et al. Hepatitis c antibody and chronic liver disease in haemophilia. Lancet 1990; 335(8698): 1117–9. doi: 10.1016/0140-6736(90)91124-S. MakrisM PrestonF TrigerD Hepatitis c antibody and chronic liver disease in haemophilia Lancet 1990 335 8698 1117 9 10.1016/0140-6736(90)91124-S Open DOISearch in Google Scholar

Merritt EC. Infected blood scandal: Background, impacts, interim compensation and inquiry outcomes. [cited 2024; 2024/08/05]. Available from: https://lordslibrary.parliament.uk/infected-blood-scandal-background-impacts-interim-compensation-and-inquiry-outcomes. MerrittEC Infected blood scandal: Background, impacts, interim compensation and inquiry outcomes. [cited 2024; 2024/08/05] Available from: https://lordslibrary.parliament.uk/infected-blood-scandal-background-impacts-interim-compensation-and-inquiry-outcomes. Search in Google Scholar

Teitel JM. Viral safety of haemophilia treatment products. Ann Med 2000; 32(7):485–92. doi: 10.3109/07853890009002024. TeitelJM Viral safety of haemophilia treatment products Ann Med 2000 32 7 485 92 10.3109/07853890009002024 Open DOISearch in Google Scholar

Allain JO, Belkhiri D, Vermeulen M, et al. Characterization of occult hepatitis B virus strains in South African blood donors. Hepatology 2009; 49(6): 1868–76. doi: 10.1002/hep.22879. AllainJO BelkhiriD VermeulenM Characterization of occult hepatitis B virus strains in South African blood donors Hepatology 2009 49 6 1868 76 10.1002/hep.22879 Open DOISearch in Google Scholar

Bell TG, Makondo E, Martinson NA, Kramvis A. Hepatitis B virus infection in human immunodeficiency virus infected southern African adults: Occult or overt–that is the question. PLoS One 2012; 7(10): e45750. doi: 10.1371/journal.pone.0045750. BellTG MakondoE MartinsonNA KramvisA Hepatitis B virus infection in human immunodeficiency virus infected southern African adults: Occult or overt–that is the question PLoS One 2012 7 10 e45750 10.1371/journal.pone.0045750 Open DOISearch in Google Scholar

Msomi N|, Ndlovu K, Gianhari J, et al. High rate of occult hepatitis B virus infection in hemodialysis units of KwaZulu-Natal, South Africa. J Med Virol 2019; 91(10): 1797–803. doi: 10.1002/jmv.25510. MsomiN NdlovuK GianhariJ High rate of occult hepatitis B virus infection in hemodialysis units of KwaZulu-Natal, South Africa J Med Virol 2019 91 10 1797 803 10.1002/jmv.25510 Open DOISearch in Google Scholar

Javanmard D, Namaei MH, Farahmand M, et al. Molecular and serological characterization of occult hepatitis B virus infection among patients with hemophilia. J Med Virol 2019; 91(8): 1519–27. doi: 10.1002/jmv.25470. JavanmardD NamaeiMH FarahmandM Molecular and serological characterization of occult hepatitis B virus infection among patients with hemophilia J Med Virol 2019 91 8 1519 27 10.1002/jmv.25470 Open DOISearch in Google Scholar

Toyoda H, Hayashi K, Murakami Y, et al. Prevalence and clinical implications of occult hepatitis b viral infection in hemophilia patients in Japan. J Med Virol 2004; 73(2): 195–9. doi: 10.1002/jmv.20075. ToyodaH HayashiK MurakamiY Prevalence and clinical implications of occult hepatitis b viral infection in hemophilia patients in Japan J Med Virol 2004 73 2 195 9 10.1002/jmv.20075 Open DOISearch in Google Scholar

Varaklioti A, Kouramba A, Ioannidou P, Katsarou O. Occult hepatitis B virus infection in Greek patients with congenital bleeding disorders. Infect Genet Evol 2017; 54: 397–401. doi: 10.1016/j.meegid.2017.07.012. VarakliotiA KourambaA IoannidouP KatsarouO Occult hepatitis B virus infection in Greek patients with congenital bleeding disorders Infect Genet Evol 2017 54 397 401 10.1016/j.meegid.2017.07.012 Open DOISearch in Google Scholar

Windyga J, Brojer E, Gronowska A, et al. Preliminary results of HBV DNA testing of Polish haemophilia patients–lack of occult HBV infection. Haemophilia 2006; 12(4): 380–3. doi: 10.1111/j.1365-2516.2006.01293.x. WindygaJ BrojerE GronowskaA Preliminary results of HBV DNA testing of Polish haemophilia patients–lack of occult HBV infection Haemophilia 2006 12 4 380 3 10.1111/j.1365-2516.2006.01293.x Open DOISearch in Google Scholar

Spearman CW, Afihene M, Ally R, et al. Hepatitis B in sub-Saharan Africa: Strategies to achieve the 2030 elimination targets. Lancet Gastroenterol Hepatol 2017; 2(12): 900–9. doi: 10.1016/S2468-1253(17)30295-9. SpearmanCW AfiheneM AllyR Hepatitis B in sub-Saharan Africa: Strategies to achieve the 2030 elimination targets Lancet Gastroenterol Hepatol 2017 2 12 900 9 10.1016/S2468-1253(17)30295-9 Open DOISearch in Google Scholar

Vermeulen M, Swanevelder R, Van Zyl G, Lelie N, Murphy EL. An assessment of hepatitis B virus prevalence in South African young blood donors born after the implementation of the infant hepatitis B virus immunization program: Implications for transfusion safety. Transfusion 2021; 61(9): 2688–700. doi: 10.1111/trf.16559. VermeulenM SwanevelderR Van ZylG LelieN MurphyEL An assessment of hepatitis B virus prevalence in South African young blood donors born after the implementation of the infant hepatitis B virus immunization program: Implications for transfusion safety Transfusion 2021 61 9 2688 700 10.1111/trf.16559 Open DOISearch in Google Scholar

European Medicines Agency. Guideline on plasma-derived medicinal products. 21 July 2011. EMA/CHMP/BWP/706271/2010. Available from https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-plasma-derived-medicinal-products_en.pdf (accessed June 2025). European Medicines Agency Guideline on plasma-derived medicinal products 21 July 2011 EMA/CHMP/BWP/706271/2010 Available from https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-plasma-derived-medicinal-products_en.pdf (accessed June 2025). Search in Google Scholar

Samal J, Kandpal M. Vivekandandan P. Molecular mechanisms underlying occult hepatitis B virus infection. Clin Microbiol Rev 2012; 25(1): 142–63. doi: 10.1128/CMR.00018-11. SamalJ KandpalM Vivekandandan P. Molecular mechanisms underlying occult hepatitis B virus infection Clin Microbiol Rev 2012 25 1 142 63 10.1128/CMR.00018-11 Open DOISearch in Google Scholar