<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec id="j_jccm-2021-0037_s_006">
<h3>Introduction</h3>
<p>Inhaled epoprostenol (iEpo) is a pulmonary vasodilator used to treat refractory respiratory failure, including that caused by Coronavirus 2019 (COVID-19) pneumonia.</p>
</sec>
<sec id="j_jccm-2021-0037_s_007">
<h3>Aim of Study</h3>
<p>To describe the experience at three teaching hospitals using iEpo for severe respiratory failure due to COVID-19 and evaluate its efficacy in improving oxygenation.</p>
</sec>
<sec id="j_jccm-2021-0037_s_008">
<h3>Methods</h3>
<p>Fifteen patients were included who received iEpo, had confirmed COVID-19 and had an arterial blood gas measurement in the 12 hours before and 24 hours after iEpo initiation.</p>
</sec>
<sec id="j_jccm-2021-0037_s_009">
<h3>Results</h3>
<p>Eleven patients received prone ventilation before iEpo (73.3%), and six (40%) were paralyzed. The partial pressure of arterial oxygen to fraction of inspired oxygen (P/F ratio) improved from 95.7 mmHg to 118.9 mmHg (p=0.279) following iEpo initiation. In the nine patients with severe ARDS, the mean P/F ratio improved from 66.1 mmHg to 95.7 mmHg (p=0.317). Ultimately, four patients (26.7%) were extubated after an average of 9.9 days post-initiation.</p>
</sec>
<sec id="j_jccm-2021-0037_s_010">
<h3>Conclusions</h3>
<p>The findings demonstrated a trend towards improvement in oxygenation in critically ill COVID-19 patients. Although limited by the small sample size, the results of this case series portend further investigation into the role of iEpo for severe respiratory failure associated with COVID-19.</p>
</sec></abstract>

Introduction
Inhaled epoprostenol (iEpo) is a pulmonary vasodilator used to treat refractory respiratory failure, including that caused by Coronavirus 2019 (COVID-19) pneumonia.


Aim of Study
To describe the experience at three teaching hospitals using iEpo for severe respiratory failure due to COVID-19 and evaluate its efficacy in improving oxygenation.


Methods
Fifteen patients were included who received iEpo, had confirmed COVID-19 and had an arterial blood gas measurement in the 12 hours before and 24 hours after iEpo initiation.


Results
Eleven patients received prone ventilation before iEpo (73.3%), and six (40%) were paralyzed. The partial pressure of arterial oxygen to fraction of inspired oxygen (P/F ratio) improved from 95.7 mmHg to 118.9 mmHg (p=0.279) following iEpo initiation. In the nine patients with severe ARDS, the mean P/F ratio improved from 66.1 mmHg to 95.7 mmHg (p=0.317). Ultimately, four patients (26.7%) were extubated after an average of 9.9 days post-initiation.


Conclusions
The findings demonstrated a trend towards improvement in oxygenation in critically ill COVID-19 patients. Although limited by the small sample size, the results of this case series portend further investigation into the role of iEpo for severe respiratory failure associated with COVID-19.

The Use of Inhaled Epoprostenol for Acute Respiratory Distress Syndrome Secondary due to COVID-19: A Case Series

The Journal of Critical Care Medicine

This work is licensed under the Creative Commons Attribution 4.0 International License.

Introduction
Inhaled epoprostenol (iEpo) is a pulmonary vasodilator used to treat refractory respiratory failure, including that caused by Coronavirus 2019...

The Use of Inhaled Epoprostenol for Acute Respiratory Distress Syndrome Secondary due to COVID-19: A Case Series

Article Category: Case report

Published Online: Nov 17, 2021

Page range: 33 - 40

Received: Nov 24, 2020

Accepted: Sep 27, 2021

DOI: https://doi.org/10.2478/jccm-2021-0037

Keywords
epoprostenol, acute respiratory distress syndrome, severe acute respiratory syndrome, coronavirus

© 2022 Komal Imtiaz, Wade Jodeh, Dave Sudekum, Bruno DiGiovine, Jason Hecht, published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

The Use of Inhaled Epoprostenol for Acute Respiratory Distress Syndrome Secondary due to COVID-19: A Case Series

Article Category: Case report

Published Online: Nov 17, 2021

Page range: 33 - 40

Received: Nov 24, 2020

Accepted: Sep 27, 2021

DOI: https://doi.org/10.2478/jccm-2021-0037

Keywordsepoprostenol, acute respiratory distress syndrome, severe acute respiratory syndrome, coronavirus

© 2022 Komal Imtiaz, Wade Jodeh, Dave Sudekum, Bruno DiGiovine, Jason Hecht, published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
epoprostenol, acute respiratory distress syndrome, severe acute respiratory syndrome, coronavirus