<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_jccm-2019-0018_s_006_w2aab3b7b6b1b6b1aab1c18b1Aa"><h3>Introduction</h3><p>In an attempt to identify patients who have successfully survived a resuscitated cardiac arrest (CA), attention is drawn to resistin and S100B protein, two biomarkers that have been studied in relation to CA.</p></sec><sec id="j_jccm-2019-0018_s_007_w2aab3b7b6b1b6b1aab1c18b2Aa"><h3>Aim</h3><p>The study aimed to identify the potential cut-off serum values for resistin and S100B in patients who had CA, compared to healthy volunteers, given that, currently, none of the markers have normal and pathological reference range limits for human assay levels related to this pathology.</p></sec><sec id="j_jccm-2019-0018_s_008_w2aab3b7b6b1b6b1aab1c18b3Aa"><h3>Materials and Methods</h3><p>Forty patients, resuscitated after out-of-hospital CA and forty healthy controls, were included in the study. All patients were followed up for seventy-two hours after CA or until death. Blood samples for biomarkers were collected on admission to the ED (0-time interval) and at 6, 12, 24, 48 and 72 hours following resuscitation. Only one blood sample was collected from the controls. The serum concentrations of biomarkers were measured.</p></sec><sec id="j_jccm-2019-0018_s_009_w2aab3b7b6b1b6b1aab1c18b4Aa"><h3>Results</h3><p>For each time interval, median serum levels of resistin and S100 B were ​ significantly higher in patients with CA compared to healthy controls. The cut-of value for resistin in patients with CA, at the 12-hours versus controls, was > 8.2 ng/ml. The cut-of value for S100B in patients with CA versus controls recorded at 6 hours, was > 11.6 pg/ml.</p></sec><sec id="j_jccm-2019-0018_s_010_w2aab3b7b6b1b6b1aab1c18b5Aa"><h3>Conclusion</h3><p>Serum levels of resistin and S100B are higher among resuscitated CA patients compared to controls.</p></sec></abstract>

IntroductionIn an attempt to identify patients who have successfully survived a resuscitated cardiac arrest (CA), attention is drawn to resistin and S100B protein, two biomarkers that have been studied in relation to CA.AimThe study aimed to identify the potential cut-off serum values for resistin and S100B in patients who had CA, compared to healthy volunteers, given that, currently, none of the markers have normal and pathological reference range limits for human assay levels related to this pathology.Materials and MethodsForty patients, resuscitated after out-of-hospital CA and forty healthy controls, were included in the study. All patients were followed up for seventy-two hours after CA or until death. Blood samples for biomarkers were collected on admission to the ED (0-time interval) and at 6, 12, 24, 48 and 72 hours following resuscitation. Only one blood sample was collected from the controls. The serum concentrations of biomarkers were measured.ResultsFor each time interval, median serum levels of resistin and S100 B were ​ significantly higher in patients with CA compared to healthy controls. The cut-of value for resistin in patients with CA, at the 12-hours versus controls, was > 8.2 ng/ml. The cut-of value for S100B in patients with CA versus controls recorded at 6 hours, was > 11.6 pg/ml.ConclusionSerum levels of resistin and S100B are higher among resuscitated CA patients compared to controls.

Determination of Cut-off Serum Values for Resistin and S100B Protein in Patients Who Survived a Cardiac Arrest

The Journal of Critical Care Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

IntroductionIn an attempt to identify patients who have successfully survived a resuscitated cardiac arrest (CA), attention is drawn to resistin and S100B...

Determination of Cut-off Serum Values for Resistin and S100B Protein in Patients Who Survived a Cardiac Arrest

Article Category: Research Article

Published Online: Aug 09, 2019

Page range: 97 - 102

Received: May 18, 2019

Accepted: Jul 30, 2019

DOI: https://doi.org/10.2478/jccm-2019-0018

Keywords
resistin, S100B protein, biomarkers, cardiac arrest

© 2019 Raluca M. Tat, Adela Golea, Ştefan C. Vesa, Daniela Ionescu, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Determination of Cut-off Serum Values for Resistin and S100B Protein in Patients Who Survived a Cardiac Arrest

Article Category: Research Article

Published Online: Aug 09, 2019

Page range: 97 - 102

Received: May 18, 2019

Accepted: Jul 30, 2019

DOI: https://doi.org/10.2478/jccm-2019-0018

Keywordsresistin, S100B protein, biomarkers, cardiac arrest

© 2019 Raluca M. Tat, Adela Golea, Ştefan C. Vesa, Daniela Ionescu, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
resistin, S100B protein, biomarkers, cardiac arrest