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Effect of Gender on the Radiation Sensitivity of Murine Blood Cells

Paul C. Billings

Paul C. Billings

Department of Radiation Oncology, University of Pennsylvania, Perelman School of MedicinePhiladelphia, PA, United States
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Billings, Paul C.
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Ana L. Romero-Weaver

Ana L. Romero-Weaver

Department of Radiation Oncology, University of Pennsylvania, Perelman School of MedicinePhiladelphia, PA, United States
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Romero-Weaver, Ana L.
 and 
Ann R. Kennedy

Ann R. Kennedy

Department of Radiation Oncology, University of Pennsylvania, Perelman School of MedicinePhiladelphia, PA, United States
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Kennedy, Ann R.
  
Jan 18, 2022
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Article Category: Research Article
Published Online: Jan 18, 2022
Page range: 25 - 31
DOI: https://doi.org/10.2478/gsr-2014-0002
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© 2014 Paul C. Billings et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1.

WBC (A), Lymphocytes (B), granulocytes (C) and monocytes (D) in male (●) and female (▪) mice at 0, 1, 4, 11, and 16 days following treatment with 2 Gy gamma radiation. Results are presented as mean ± SE of relative cell number (percent of control). Note that the decline in monocytes at 1 day post-irradiation was greater in females, compared with male mice (P= 0.024).
WBC (A), Lymphocytes (B), granulocytes (C) and monocytes (D) in male (●) and female (▪) mice at 0, 1, 4, 11, and 16 days following treatment with 2 Gy gamma radiation. Results are presented as mean ± SE of relative cell number (percent of control). Note that the decline in monocytes at 1 day post-irradiation was greater in females, compared with male mice (P= 0.024).

Figure 2.

Platelet counts in male (●) and female (▪) mice at 0, 1, 4, 11, and 16 days following treatment with 1 Gy (A) or 2 Gy gamma radiation (B). Results are presented as mean ± SE of Relative Cell Number (percent of control). Note that platelet counts rebound faster in male mice on day 16, compared with female mice.
Platelet counts in male (●) and female (▪) mice at 0, 1, 4, 11, and 16 days following treatment with 1 Gy (A) or 2 Gy gamma radiation (B). Results are presented as mean ± SE of Relative Cell Number (percent of control). Note that platelet counts rebound faster in male mice on day 16, compared with female mice.

Blood cell counts in non-irradiated male and female C3H/HeN mice_1

Cells & Other Parameters Male Female P-value4
AVE2 n3 AVE2 n3
    WBCs (x 103/µl) 7.6 ± 2.5 42 7.4± 2.1 41 0.68
    RBCs (x 106/µl) 7.9 ± 0.5 41 7.9 ± 0.6 41 0.87
    Hemoglobin (g/dl) 13.5 ± 0.6 41 13.7 ± 0.5 41 0.2
    Hematocrit (%) 44.2 ± 2.4 41 44 ± 1.9 41 0.64
    Platelets (x 103/µl)5 1114 ± 196 41 966 ± 202 41 0.0012
    Neutrophils (/µl) 1848 ± 1416 41 1493 ± 544 42 0.13
    Lymphocytes (/µl) 5291 ± 1569 42 5561 ± 1655 42 0.44
    Monocytes (/µl) 154 ± 127 42 145 ± 164 42 0.76
    Eosinophils (/µl) 127 ± 85 42 130 ± 87 42 0.86
    Basophils (/µl) 53 ± 71 42 55 ± 68 42 0.89
    Granulocytes (/µl)6 2029 ± 1443 41 1678 ± 594 42 0.15

Platelet counts in mice following radiation exposure_

Gender Dose (Gy) Time Post-IR AVE SD n
Male 0 1 1108 322 11
Female 0 1 1020 228 10
Male    0.5 1 1082 151 10
Female    0.5 1 1094 98 10
Male 1 1 1091 192 9
Female 1 1 1011 75 9
Male 2 1 1123 110 8
Female 2 1 1007 158 10
Male 0 4 1061 204 11
Female 0 4 905 224 11
Male    0.5 4 1000 217 10
Female    0.5 4 1092 207 9
Male 1 4 1030 204 10
Female 1 4 1088 240 8
Male 2 4 1072 198 10
Female 2 4 1034 99 10
Male 0 11 1096 212 10
Female 0 11 962 204 10
Male    0.5 11 685 279 10
Female    0.5 11 780 141 9
Male 1 11 418 133 9
Female 1 11 385 72 9
Male 2 11 334 105 8
Female 2 11 248 61 10
Male 0 16 1116 245 10
Female 0 16 1028 65 9
Male    0.5 16 1185 101 5
Female    0.5 16 1016 57 9
Male 1 16 1163 102 10
Female 1 16 834 95 10
Male 2 16 871 154 10
Female 2 16 470 159 9
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