<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Bacterial meningitis is a devastating worldwide disease. Half of the survivors of meningitis remain with permanent neurological sequelae. The pathogenesis of meningitis is based on a complex host-pathogen interaction. <italic>Streptococcus pneumoniae</italic> is a life-threatening neuroinvasive pathogen that asymptomatically colonizes the upper respiratory tract. Adherence of pneumococci to the host epithelium is a prerequisite in the onset of streptococcal infections; such adherence is favored by the formation of bacterial pili. In this article, we will describe the pneumococcal pili and its contribution to the onset of meningitis.</p></abstract>

Bacterial meningitis is a devastating worldwide disease. Half of the survivors of meningitis remain with permanent neurological sequelae. The pathogenesis of meningitis is based on a complex host-pathogen interaction. Streptococcus pneumoniae is a life-threatening neuroinvasive pathogen that asymptomatically colonizes the upper respiratory tract. Adherence of pneumococci to the host epithelium is a prerequisite in the onset of streptococcal infections; such adherence is favored by the formation of bacterial pili. In this article, we will describe the pneumococcal pili and its contribution to the onset of meningitis.

Contribution of Pili of <italic>S. Pneumoniae</italic> in the Onset of Meningitis

Laboratory of Biomedical Microbiology and Immunology

University of Veterinary Medicine and Pharmacy

Institute of Neuroimmunology of the Slovak Academy of Science

Folia Veterinaria

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Contribution of Pili of  in the Onset of Meningitis

Bacterial meningitis is a devastating worldwide disease. Half of the survivors of meningitis remain with permanent neurological sequelae. The pathogenesis of...

Contribution of Pili of S. Pneumoniae in the Onset of Meningitis

Published Online: Apr 11, 2018

Page range: 67 - 72

Received: Dec 04, 2017

Accepted: Feb 08, 2018

DOI: https://doi.org/10.2478/fv-2018-0010

Keywords
meningitis, pili,

© 2018 Jiménez-Munguía, I. et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Contribution of Pili of S. Pneumoniae in the Onset of Meningitis

Published Online: Apr 11, 2018

Page range: 67 - 72

Received: Dec 04, 2017

Accepted: Feb 08, 2018

DOI: https://doi.org/10.2478/fv-2018-0010

Keywordsmeningitis, pili,

© 2018 Jiménez-Munguía, I. et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
meningitis, pili,