1. bookVolume 62 (2018): Issue 1 (March 2018)
Journal Details
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Journal
eISSN
2453-7837
First Published
30 Mar 2016
Publication timeframe
4 times per year
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English
access type Open Access

The Role of Meningococcal Porin B in Protein-Protein Interactions with Host Cells

Published Online: 11 Apr 2018
Volume & Issue: Volume 62 (2018) - Issue 1 (March 2018)
Page range: 52 - 58
Received: 04 Dec 2017
Accepted: 26 Jan 2018
Journal Details
License
Format
Journal
eISSN
2453-7837
First Published
30 Mar 2016
Publication timeframe
4 times per year
Languages
English
Abstract

Neisseria meningitidis is a Gram-negative diplococcus responsible for bacterial meningitis and fatal sepsis. Ligand-receptor interactions are one of the main steps in the development of neuroinvasion. Porin B (PorB), neisserial outer membrane protein (ligand), binds to host receptors and triggers many cell signalling cascades allowing the meningococcus to damage the host cells or induce immune cells responses via the TLR2-dependent mechanisms. In this paper, we present a brief review of the structure and function of PorB.

Keywords

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