1. bookVolume 62 (2018): Issue 1 (March 2018)
Journal Details
First Published
30 Mar 2016
Publication timeframe
4 times per year
access type Open Access

Crossing the Blood-Brain Barrier by Neuroinvasive Pathogens

Published Online: 11 Apr 2018
Volume & Issue: Volume 62 (2018) - Issue 1 (March 2018)
Page range: 44 - 51
Received: 04 Dec 2017
Accepted: 17 Jan 2018
Journal Details
First Published
30 Mar 2016
Publication timeframe
4 times per year

The penetration of the blood-brain barrier (BBB) and invasion of the central nervous system (CNS) are important steps for all neuroinvasive pathogens. All of the ways of pathogens passing through the BBB are still unclear. Among known pathways, pathogen traversal can occur paracellularly, transcellularly or using a “Trojan horse” mechanism. The first step of translocation across the BBB is the interactions of the pathogen’s ligands with the receptors of the host brain cells. Lyme disease, the most common vector-borne disease in the temperate zones of Europe and North America, are caused by Borreliella species (former Borrelia burgdorferi sensu lato) that affects the peripheral and the CNS. In this review, we have presented various pathogen interactions with endothelial cells, which allow the disruption of the BBB so that the pathogens can pass across the BBB.


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