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Green extraction of bioactive compounds from Azadirachta indica in aqueous glycerol and modelling and optimisation by response surface methodology


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Ahmad, S., Maqbool, A., Srivastava, A., and Gogol, S. (2019). Biological detail and therapeutic effect of Azadirachta indica (neem tree) products – a review. Evidence Based Medicine and Healthcare, 6(22), 1607–1612, doi: 10.18410/jebmh/2019/324. AhmadS. MaqboolA. SrivastavaA. GogolS. 2019 Biological detail and therapeutic effect of Azadirachta indica (neem tree) products – a review Evidence Based Medicine and Healthcare 6 22 1607 1612 10.18410/jebmh/2019/324 Open DOISearch in Google Scholar

Al-Hashemi, Z. S., and Hossain, M. A. (2016). Biological activities of different neem leaf crude extracts used locally in ayurvedic medicine. Pacific Science Review A: Natural Science and Engineering, 18(2), 128–131, doi: 10.1016/j.psra.2016.09.013. Al-HashemiZ. S. HossainM. A. 2016 Biological activities of different neem leaf crude extracts used locally in ayurvedic medicine Pacific Science Review A: Natural Science and Engineering 18 2 128 131 10.1016/j.psra.2016.09.013 Open DOISearch in Google Scholar

Anokwuru, C. P., Anyasor, G. N., Ajibaye, O., Fakoya, O., and Okebugwu, P. (2011). Effect of extraction solvents on phenolic, flavonoid and antioxidant activities of three Nigerian medicinal plants. Nature and Science, 9(7), 53–61. AnokwuruC. P. AnyasorG. N. AjibayeO. FakoyaO. OkebugwuP. 2011 Effect of extraction solvents on phenolic, flavonoid and antioxidant activities of three Nigerian medicinal plants Nature and Science 9 7 53 61 Search in Google Scholar

Apostolakis, A., Grigorakis, S., and Makris, D. P. (2014). Optimisation and comparative kinetics study of polyphenol extraction from olive leaves (Olea europaea) using heated water/glycerol mixtures. Separation and Purification Technology, 128, 89–95. ApostolakisA. GrigorakisS. MakrisD. P. 2014 Optimisation and comparative kinetics study of polyphenol extraction from olive leaves (Olea europaea) using heated water/glycerol mixtures Separation and Purification Technology 128 89 95 10.1016/j.seppur.2014.03.010Search in Google Scholar

Arivazhagan, S., Balasenthil, S., and Nagini, S. (2000). Modulatory effects of garlic and neem leaf extracts on N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)-induced oxidative stress in Wistar rats. Cell Biochemistry and Function, 18(1), 17–21, doi: 10.1002/(SICI)1099-0844(200001/03)18:1<17::AID-CBF842>3.0.CO;2-T. ArivazhaganS. BalasenthilS. NaginiS. 2000 Modulatory effects of garlic and neem leaf extracts on N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)-induced oxidative stress in Wistar rats Cell Biochemistry and Function 18 1 17 21 10.1002/(SICI)1099-0844(200001/03)18:1<17::AID-CBF842>3.0.CO;2-T Open DOISearch in Google Scholar

Ascher, K. R. S. (1993). Nonconventional insecticidal effects of pesticides available from the Neem tree, Azadirachta indica. Archives of Insect Biochemistry and Physiology, 22(3–4), 433–449, doi: 10.1002/arch.940220311. AscherK. R. S. 1993 Nonconventional insecticidal effects of pesticides available from the Neem tree, Azadirachta indica Archives of Insect Biochemistry and Physiology 22 3–4 433 449 10.1002/arch.940220311 Open DOISearch in Google Scholar

Babaoğlu, A. S., Dilek, N. M., Karakaya, M., and Unal, K. (2022). Valorization of sugar beet molasses powder by microwave and ultrasound-assisted extractions of bioactive compounds: An optimization study. Journal of Food Processing and Preservation, 46(10), e16820, doi: 10.1111/jfpp.16820. BabaoğluA. S. DilekN. M. KarakayaM. UnalK. 2022 Valorization of sugar beet molasses powder by microwave and ultrasound-assisted extractions of bioactive compounds: An optimization study Journal of Food Processing and Preservation 46 10 e16820 10.1111/jfpp.16820 Open DOISearch in Google Scholar

Bao, N., Wang, D., Fu, X., Xie, H., Gao, G., and Luo, Z. (2021). Green extraction of phenolic compounds from lotus seedpod (Receptaculum nelumbinis) assisted by ultrasound coupled with glycerol. Foods, 10(2), 239, doi: 10.3390/foods10020239. BaoN. WangD. FuX. XieH. GaoG. LuoZ. 2021 Green extraction of phenolic compounds from lotus seedpod (Receptaculum nelumbinis) assisted by ultrasound coupled with glycerol Foods 10 2 239 10.3390/foods10020239 Open DOISearch in Google Scholar

Behr, A., Eilting, J., Irawadi, K., Leschinski, J., and Lindner, F. (2008). Improved utilisation of renewable resources: New important derivatives of glycerol. Green Chemistry, 10(1), 13–30, doi: 10.1039/B710561D. BehrA. EiltingJ. IrawadiK. LeschinskiJ. LindnerF. 2008 Improved utilisation of renewable resources: New important derivatives of glycerol Green Chemistry 10 1 13 30 10.1039/B710561D Open DOISearch in Google Scholar

Breternitz, M., Kowatzki, D., Langenauer, M., Elsner, P., and Fluhr, J. W. (2008). Placebo-controlled, double-blind, randomized, prospective study of a glycerol-based emollient on eczematous skin in atopic dermatitis: Biophysical and clinical evaluation. Skin Pharmacology and Physiology, 21(1), 39–45, doi: 10.1159/000111134. BreternitzM. KowatzkiD. LangenauerM. ElsnerP. FluhrJ. W. 2008 Placebo-controlled, double-blind, randomized, prospective study of a glycerol-based emollient on eczematous skin in atopic dermatitis: Biophysical and clinical evaluation Skin Pharmacology and Physiology 21 1 39 45 10.1159/000111134 Open DOISearch in Google Scholar

Bubalo, M. C., Vidović, S., Radojčić Redovniković, I., and Jokić, S. (2015). Green solvents for green technologies. Journal of Chemical Technology & Biotechnology, 90(9), 1631–1639, doi: 10.1002/jctb.4668. BubaloM. C. VidovićS. Radojčić RedovnikovićI. JokićS. 2015 Green solvents for green technologies Journal of Chemical Technology & Biotechnology 90 9 1631 1639 10.1002/jctb.4668 Open DOISearch in Google Scholar

Cacace, J., and Mazza, G. (2003). Optimization of extraction of anthocyanins from black currants with aqueous ethanol. Journal of Food Science, 68(1), 240–248, doi: 10.1111/j.1365-2621.2003.tb14146.x. CacaceJ. MazzaG. 2003 Optimization of extraction of anthocyanins from black currants with aqueous ethanol Journal of Food Science 68 1 240 248 10.1111/j.1365-2621.2003.tb14146.x Open DOISearch in Google Scholar

Carter, P. (1971). Spectrophotometric determination of serum iron at the submicrogram level with a new reagent (ferrozine). Analytical Biochemistry, 40(2), 450–458, doi: 10.1016/0003-2697(71)90405-2. CarterP. 1971 Spectrophotometric determination of serum iron at the submicrogram level with a new reagent (ferrozine) Analytical Biochemistry 40 2 450 458 10.1016/0003-2697(71)90405-2 5551554Open DOISearch in Google Scholar

Chaaban, H., Ioannou, I., Chebil, L., Slimane, M., Gerardin, C., Paris, C., Charbonnel, C., Chekir, L., and Ghoul, M. (2017). Effect of heat processing on thermal stability and antioxidant activity of six flavonoids. Journal of Food Processing and Preservation, 41(5), e13203, doi: 10.1111/jfpp.13203. ChaabanH. IoannouI. ChebilL. SlimaneM. GerardinC. ParisC. CharbonnelC. ChekirL. GhoulM. 2017 Effect of heat processing on thermal stability and antioxidant activity of six flavonoids Journal of Food Processing and Preservation 41 5 e13203 10.1111/jfpp.13203 Open DOISearch in Google Scholar

Chao, Y.-S., Rouhan, G., Amoroso, V. B., and Chiou, W.-L. (2014). Molecular phylogeny and biogeography of the fern genus Pteris (Pteridaceae). Annals of Botany, 114(1), 109–124, doi: 10.1093/aob/mcu086. ChaoY.-S. RouhanG. AmorosoV. B. ChiouW.-L. 2014 Molecular phylogeny and biogeography of the fern genus Pteris (Pteridaceae) Annals of Botany 114 1 109 124 10.1093/aob/mcu086 407110424908681Open DOISearch in Google Scholar

Chattopadhyay, R. R. (1998). Possible biochemical mode of anti-inflammatory action of Azadirachta indica A. Juss. in rats. Indian Journal of Experimental Biology, 36(4), 418–420. ChattopadhyayR. R. 1998 Possible biochemical mode of anti-inflammatory action of Azadirachta indica A. Juss. in rats Indian Journal of Experimental Biology 36 4 418 420 Search in Google Scholar

Chemat, F., Rombaut, N., Sicaire, A.-G., Meullemiestre, A., Fabiano-Tixier, A.-S., and Abert-Vian, M. (2017). Ultrasound assisted extraction of food and natural products. Mechanisms, techniques, combinations, protocols and applications. A review. Ultrasonics Sonochemistry, 34, 540–560, doi: 10.1016/j.ultsonch.2016.06.035. ChematF. RombautN. SicaireA.-G. MeullemiestreA. Fabiano-TixierA.-S. Abert-VianM. 2017 Ultrasound assisted extraction of food and natural products. Mechanisms, techniques, combinations, protocols and applications. A review Ultrasonics Sonochemistry 34 540 560 10.1016/j.ultsonch.2016.06.035 27773280Open DOISearch in Google Scholar

Che Sulaiman, I. S., Basri, M., Fard Masoumi, H. R., Chee, W. J., Ashari, S. E., and Ismail, M. (2017). Effects of temperature, time, and solvent ratio on the extraction of phenolic compounds and the anti-radical activity of Clinacanthus nutans Lindau leaves by response surface methodology. Chemistry Central Journal, 11, 54, doi: 10.1186/s13065-017-0285-1 Che SulaimanI. S. BasriM. Fard MasoumiH. R. CheeW. J. AshariS. E. IsmailM. 2017 Effects of temperature, time, and solvent ratio on the extraction of phenolic compounds and the anti-radical activity of Clinacanthus nutans Lindau leaves by response surface methodology Chemistry Central Journal 11 54 10.1186/s13065-017-0285-1547128529086900Open DOISearch in Google Scholar

Clarke, C. J., Tu, W.-C., Levers, O., Bröhl, A., and Hallett, J. P. (2018). Green and sustainable solvents in chemical processes. Chemical Reviews, 118(2), 747–800, doi: 10.1021/acs.chemrev.7b00571. ClarkeC. J. TuW.-C. LeversO. BröhlA. HallettJ. P. 2018 Green and sustainable solvents in chemical processes Chemical Reviews 118 2 747 800 10.1021/acs.chemrev.7b00571 29300087Open DOISearch in Google Scholar

Czyrski, A., and Sznura, J. (2019). The application of box-behnken-design in the optimization of HPLC separation of fluoroquinolones. Scientific Reports, 9(1), 19458, doi: 10.1038/s41598-019-55761-z. CzyrskiA. SznuraJ. 2019 The application of box-behnken-design in the optimization of HPLC separation of fluoroquinolones Scientific Reports 9 1 19458 10.1038/s41598-019-55761-z 692335731857613Open DOISearch in Google Scholar

De Ancos, B., Sgroppo, S., Plaza, L., and Pilar Cano, M. (2002). Possible nutritional and health-related value promotion in orange juice preserved by high-pressure treatment. Journal of the Science of Food and Agriculture, 82(8), 790–796, doi: 10.1002/jsfa.1093. De AncosB. SgroppoS. PlazaL. Pilar CanoM. 2002 Possible nutritional and health-related value promotion in orange juice preserved by high-pressure treatment Journal of the Science of Food and Agriculture 82 8 790 796 10.1002/jsfa.1093 Open DOISearch in Google Scholar

Ekaluo, U. B., Ikpeme, E. V., Udensi, O. U., Ekerette, E. E., Usen, S. O., and Usoroh, S. F. (2015). Comparative in vitro assessment of drumstick (Moringa oleifera) and neem (Azadiracta indica) leaf extracts for antioxidant and free radical scavenging activities. Research Journal of Medicinal Plant, 9(1), 24–33, doi: 10.3923/rjmp.2015.24.33. EkaluoU. B. IkpemeE. V. UdensiO. U. EkeretteE. E. UsenS. O. UsorohS. F. 2015 Comparative in vitro assessment of drumstick (Moringa oleifera) and neem (Azadiracta indica) leaf extracts for antioxidant and free radical scavenging activities Research Journal of Medicinal Plant 9 1 24 33 10.3923/rjmp.2015.24.33 Open DOISearch in Google Scholar

Farjaminezhad, R., and Garoosi, G. (2020). Establishment of green analytical method for ultrasound-assisted extraction of azadirachtin, mevalonic acid and squalene from cell suspension culture of Azadirachta indica using response surface methodology. Industrial Crops and Products, 144, 111946, doi: 10.1016/j.indcrop.2019.111946. FarjaminezhadR. GaroosiG. 2020 Establishment of green analytical method for ultrasound-assisted extraction of azadirachtin, mevalonic acid and squalene from cell suspension culture of Azadirachta indica using response surface methodology Industrial Crops and Products 144 111946 10.1016/j.indcrop.2019.111946 Open DOISearch in Google Scholar

Gouda, S., Das, G., Sen, S. K., Shin, H. S., and Patra, J. K. (2016). Endophytes: A treasure house of bioactive compounds of medicinal importance. Frontiers in Microbiology, 7, 1538, doi: 10.3389/fmicb.2016.01538. GoudaS. DasG. SenS. K. ShinH. S. PatraJ. K. 2016 Endophytes: A treasure house of bioactive compounds of medicinal importance Frontiers in Microbiology 7 1538 10.3389/fmicb.2016.01538 504114127746767Open DOISearch in Google Scholar

Han, J. H. (Ed.) (2013). Innovations in food packaging. New York, USA: Academic Press. HanJ. H. (Ed.) 2013 Innovations in food packaging New York, USA Academic Press Search in Google Scholar

Herald, T. J., Gadgil, P., and Tilley, M. (2012). High-throughput micro plate assays for screening flavonoid content and DPPH-scavenging activity in sorghum bran and flour. Journal of the Science of Food and Agriculture, 92(11), 2326–2331, doi: 10.1002/jsfa.5633. HeraldT. J. GadgilP. TilleyM. 2012 High-throughput micro plate assays for screening flavonoid content and DPPH-scavenging activity in sorghum bran and flour Journal of the Science of Food and Agriculture 92 11 2326 2331 10.1002/jsfa.5633 22419130Open DOISearch in Google Scholar

Hossain, M. A., Al-Toubi, W. A. S., Weli, A. M., Al-Riyami, Q. A., and Al-Sabahi, J. N. (2013). Identification and characterization of chemical compounds in different crude extracts from leaves of Omani neem. Journal of Taibah University for Science, 7(4), 181–188, doi: 10.1016/j.jtusci.2013.05.003. HossainM. A. Al-ToubiW. A. S. WeliA. M. Al-RiyamiQ. A. Al-SabahiJ. N. 2013 Identification and characterization of chemical compounds in different crude extracts from leaves of Omani neem Journal of Taibah University for Science 7 4 181 188 10.1016/j.jtusci.2013.05.003 Open DOISearch in Google Scholar

Huamán-Castilla, N. L., Mariotti-Celis, M. S., Martínez-Cifuentes, M., and Pérez-Correa, J. R. (2020). Glycerol as alternative co-solvent for water extraction of polyphenols from Carménère pomace: Hot pressurized liquid extraction and computational chemistry calculations. Biomolecules, 10(3), 474, doi: 10.3390/biom10030474. Huamán-CastillaN. L. Mariotti-CelisM. S. Martínez-CifuentesM. Pérez-CorreaJ. R. 2020 Glycerol as alternative co-solvent for water extraction of polyphenols from Carménère pomace: Hot pressurized liquid extraction and computational chemistry calculations Biomolecules 10 3 474 10.3390/biom10030474 717527332244874Open DOISearch in Google Scholar

Huang, H., Belwal, T., Jiang, L., Hu, J., Limwachiranon, J., Li, L., Ren, G., Zhang, X., and Luo, Z. (2019). Valorization of lotus byproduct (Receptaculum nelumbinis) under green extraction condition. Food and Bioproducts Processing, 115, 110–117, doi: 10.1016/j.fbp.2019.03.006. HuangH. BelwalT. JiangL. HuJ. LimwachiranonJ. LiL. RenG. ZhangX. LuoZ. 2019 Valorization of lotus byproduct (Receptaculum nelumbinis) under green extraction condition Food and Bioproducts Processing 115 110 117 10.1016/j.fbp.2019.03.006 Open DOISearch in Google Scholar

Jabraili, A., Pirsa, S., Pirouzifard, M. K., and Amiri, S. (2021). Biodegradable nanocomposite film based on gluten/silica/calcium chloride: Physicochemical properties and bioactive compounds extraction capacity. Journal of Polymers and the Environment, 29(8), 2557–2571, doi: 10.1007/s10924-021-02050-4. JabrailiA. PirsaS. PirouzifardM. K. AmiriS. 2021 Biodegradable nanocomposite film based on gluten/silica/calcium chloride: Physicochemical properties and bioactive compounds extraction capacity Journal of Polymers and the Environment 29 8 2557 2571 10.1007/s10924-021-02050-4 Open DOISearch in Google Scholar

Jha, A. K., and Sit, N. (2021). Extraction of bioactive compounds from plant materials using combination of various novel methods: A review. Trends in Food Science & Technology, 119(1), 579–591, doi: 10.1016/j.tifs.2021.11.019. JhaA. K. SitN. 2021 Extraction of bioactive compounds from plant materials using combination of various novel methods: A review Trends in Food Science & Technology 119 1 579 591 10.1016/j.tifs.2021.11.019 Open DOISearch in Google Scholar

Jiskani, A., Aydar, A., and Ahmed, D. (2021). Optimization of ultrasound-assisted extraction of antioxidant compounds from Rumex hastatus with response surface methodology. Journal of Food Processing and Preservation, 45(11), e15983, doi: 10.1111/jfpp.15983. JiskaniA. AydarA. AhmedD. 2021 Optimization of ultrasound-assisted extraction of antioxidant compounds from Rumex hastatus with response surface methodology Journal of Food Processing and Preservation 45 11 e15983 10.1111/jfpp.15983 Open DOISearch in Google Scholar

Jordan, A., Hall, C. G. J., Thorp, L. R., and Sneddon, H. F. (2022). Replacement of less-preferred dipolar aprotic and ethereal solvents in synthetic organic chemistry with more sustainable alternatives. Chemical Reviews, 122(6), 6749–6794, doi: 10.1021/acs.chemrev.1c00672. JordanA. HallC. G. J. ThorpL. R. SneddonH. F. 2022 Replacement of less-preferred dipolar aprotic and ethereal solvents in synthetic organic chemistry with more sustainable alternatives Chemical Reviews 122 6 6749 6794 10.1021/acs.chemrev.1c00672 909818235201751Open DOISearch in Google Scholar

Karakashov, B., Grigorakis, S., Loupassaki, S., and Makris, D. P. (2015). Optimisation of polyphenol extraction from Hypericum perforatum (St. John's Wort) using aqueous glycerol and response surface methodology. Journal of Applied Research on Medicinal and Aromatic Plants, 2(1), 1–8. KarakashovB. GrigorakisS. LoupassakiS. MakrisD. P. 2015 Optimisation of polyphenol extraction from Hypericum perforatum (St. John's Wort) using aqueous glycerol and response surface methodology Journal of Applied Research on Medicinal and Aromatic Plants 2 1 1 8 10.1016/j.jarmap.2014.11.002Search in Google Scholar

Khemakhem, I., Ahmad-Qasem, M. H., Catalán, E. B., Micol, V., García-Pérez, J. V., Ayadi, M. A., and Bouaziz, M. (2017). Kinetic improvement of olive leaves' bioactive compounds extraction by using power ultrasound in a wide temperature range. Ultrasonics Sonochemistry, 34, 466–473, doi: 10.1016/j.ultsonch.2016.06.010. KhemakhemI. Ahmad-QasemM. H. CatalánE. B. MicolV. García-PérezJ. V. AyadiM. A. BouazizM. 2017 Kinetic improvement of olive leaves' bioactive compounds extraction by using power ultrasound in a wide temperature range Ultrasonics Sonochemistry 34 466 473 10.1016/j.ultsonch.2016.06.010 27773270Open DOISearch in Google Scholar

Khupse, N. D., and Kumar, A. (2009). Dramatic change in viscosities of pure ionic liquids upon addition of molecular solvents. Journal of Solution Chemistry, 38(5), 589–600. KhupseN. D. KumarA. 2009 Dramatic change in viscosities of pure ionic liquids upon addition of molecular solvents Journal of Solution Chemistry 38 5 589 600 10.1007/s10953-009-9390-7Search in Google Scholar

Kowalska, G., Baj, T., Kowalski, R., and Szymańska, J. (2021). Optimization of glycerol–water extraction of selected bioactive compounds from peppermint and common nettle. Antioxidants, 10(5), 817, doi: 10.3390/antiox10050817. KowalskaG. BajT. KowalskiR. SzymańskaJ. 2021 Optimization of glycerol–water extraction of selected bioactive compounds from peppermint and common nettle Antioxidants 10 5 817 10.3390/antiox10050817 816069634065576Open DOISearch in Google Scholar

Makris, D. P., and Lalas, S. (2020). Glycerol and glycerol-based deep eutectic mixtures as emerging green solvents for polyphenol extraction: The evidence so far. Molecules, 25(24), 5842, doi: 10.3390/molecules25245842. MakrisD. P. LalasS. 2020 Glycerol and glycerol-based deep eutectic mixtures as emerging green solvents for polyphenol extraction: The evidence so far Molecules 25 24 5842 10.3390/molecules25245842 776385933322032Open DOISearch in Google Scholar

Maran, B. A.V., Josmeh, D., Tan, J. K., Yong, Y. S., and Shah, M. D. (2021). Efficacy of the aqueous extract of Azadirachta indica against the marine parasitic leech and its phytochemical profiling. Molecules, 26(7), 1908, doi: 10.3390/molecules26071908. MaranB. A.V. JosmehD. TanJ. K. YongY. S. ShahM. D. 2021 Efficacy of the aqueous extract of Azadirachta indica against the marine parasitic leech and its phytochemical profiling Molecules 26 7 1908 10.3390/molecules26071908 803793833805254Open DOISearch in Google Scholar

Naczk, M., and Shahidi, F. (2006). Phenolics in cereals, fruits and vegetables: Occurrence, extraction and analysis. Journal of Pharmaceutical and Biomedical Analysis, 41(5), 1523–1542, doi: 10.1016/j.jpba.2006.04.002. NaczkM. ShahidiF. 2006 Phenolics in cereals, fruits and vegetables: Occurrence, extraction and analysis Journal of Pharmaceutical and Biomedical Analysis 41 5 1523 1542 10.1016/j.jpba.2006.04.002 16753277Open DOISearch in Google Scholar

Nde, D. B., and Foncha, A. C. (2020). Optimization methods for the extraction of vegetable oils: A review. Processes, 8(2), 209, doi: 10.3390/pr8020209. NdeD. B. FonchaA. C. 2020 Optimization methods for the extraction of vegetable oils: A review Processes 8 2 209 10.3390/pr8020209 Open DOISearch in Google Scholar

Ogidi, O. I., Noahayebabogha, M., Eze, P. U., Okiemute, O., and Okafor, C. E. (2021). Determination of phytoconstituents and antimicrobial activities of aqueous and methanol extracts of neem (Azadirachta indica) leaves. International Journal of Pharmacognosy and Chemistry, 2(2), 60–67, doi: 10.46796/ijpc.vi.155. OgidiO. I. NoahayebaboghaM. EzeP. U. OkiemuteO. OkaforC. E. 2021 Determination of phytoconstituents and antimicrobial activities of aqueous and methanol extracts of neem (Azadirachta indica) leaves International Journal of Pharmacognosy and Chemistry 2 2 60 67 10.46796/ijpc.vi.155 Open DOISearch in Google Scholar

Oke, E. O., Adeyi, O., Okolo, B. I., Adeyi, J. A., Ayanyemi, J., Osoh, K. A., and Adegoke, T. S. (2020). Phenolic compound extraction from Nigerian Azadirachta indica leaves: Response surface and neuro-fuzzy modelling performance evaluation with Cuckoo search multi-objective optimization. Results in Engineering, 8, 100160, doi: 10.1016/j.rineng.2020.100160. OkeE. O. AdeyiO. OkoloB. I. AdeyiJ. A. AyanyemiJ. OsohK. A. AdegokeT. S. 2020 Phenolic compound extraction from Nigerian Azadirachta indica leaves: Response surface and neuro-fuzzy modelling performance evaluation with Cuckoo search multi-objective optimization Results in Engineering 8 100160 10.1016/j.rineng.2020.100160 Open DOISearch in Google Scholar

Ozgven, A., and Ozturk, D. (2022). A numerical optimization approach for removal of Astrazon Pink FG from aqueous media by Fenton oxidation. Arabian Journal for Science and Engineering, 1–22, doi: 10.1007/s13369-022-06996-y. OzgvenA. OzturkD. 2022 A numerical optimization approach for removal of Astrazon Pink FG from aqueous media by Fenton oxidation Arabian Journal for Science and Engineering 1 22 10.1007/s13369-022-06996-y Open DOISearch in Google Scholar

Pandey, G., Verma, K., and Singh, M. (2014). Evaluation of phytochemical, antibacterial and free radical scavenging properties of Azadirachta indica (neem) leaves. International Journal of Pharmacy and Pharmaceutical Sciences, 6(2), 444–447. PandeyG. VermaK. SinghM. 2014 Evaluation of phytochemical, antibacterial and free radical scavenging properties of Azadirachta indica (neem) leaves International Journal of Pharmacy and Pharmaceutical Sciences 6 2 444 447 Search in Google Scholar

Parvez, S., Wani, I. A., and Masoodi, F. A. (2022). Extraction optimization of green tea beverage (Noon Chai) for yield, polyphenols and caffeine using response surface methodology. Arabian Journal for Science and Engineering, 47(1), 227–239, doi: 10.1007/s13369-021-05918-8. ParvezS. WaniI. A. MasoodiF. A. 2022 Extraction optimization of green tea beverage (Noon Chai) for yield, polyphenols and caffeine using response surface methodology Arabian Journal for Science and Engineering 47 1 227 239 10.1007/s13369-021-05918-8 Open DOISearch in Google Scholar

Phuyal, N., Jha, P. K., Raturi, P. P., and Rajbhandary, S. (2020). Total phenolic, flavonoid contents, and antioxidant activities of fruit, seed, and bark extracts of Zanthoxylum armatum DC. The Scientific World Journal, 2020, 8780704, doi: 10.1155/2020/8780704. PhuyalN. JhaP. K. RaturiP. P. RajbhandaryS. 2020 Total phenolic, flavonoid contents, and antioxidant activities of fruit, seed, and bark extracts of Zanthoxylum armatum DC The Scientific World Journal 2020 8780704 10.1155/2020/8780704 710245332256249Open DOISearch in Google Scholar

Rao, P. S., Subramanayam, G., and Sridhar, P. R. (2019). Quercetin 3-galactoside from Azadirachta indica. Journal of Advances in Molecular Biology, 3(1), 1–8, doi: 10.22606/jamb.2019.31001. RaoP. S. SubramanayamG. SridharP. R. 2019 Quercetin 3-galactoside from Azadirachta indica Journal of Advances in Molecular Biology 3 1 1 8 10.22606/jamb.2019.31001 Open DOISearch in Google Scholar

Rupasinghe, H. V., Kathirvel, P., and Huber, G. M. (2011). Ultrasonication-assisted solvent extraction of quercetin glycosides from ‘Idared’ apple peels. Molecules, 16(12), 9783–9791, doi: 10.3390/molecules16129783. RupasingheH. V. KathirvelP. HuberG. M. 2011 Ultrasonication-assisted solvent extraction of quercetin glycosides from ‘Idared’ apple peels Molecules 16 12 9783 9791 10.3390/molecules16129783 626434822117169Open DOISearch in Google Scholar

Santiago, D. M., Zubia, C., Pacia, S. E., and Duque, S. M. M. (2021). Optimization of antioxidant extraction from kalumpit (Terminalia microcarpa Decne) fruits. Journal of Microbiology, Biotechnology and Food Sciences, 10(2), 301–309, doi: 10.15414/jmbfs.2020.10.2.301-309. SantiagoD. M. ZubiaC. PaciaS. E. DuqueS. M. M. 2021 Optimization of antioxidant extraction from kalumpit (Terminalia microcarpa Decne) fruits Journal of Microbiology, Biotechnology and Food Sciences 10 2 301 309 10.15414/jmbfs.2020.10.2.301-309 Open DOISearch in Google Scholar

Saroyo, H., and Arifah, I. A. N. (2021). Antioxidant activity using DPPH & FRAP method and their correlation with the levels of phenolic and flavonoid compounds from nemba plants (Azadirachta indica A. Juss). Journal of Nutraceuticals and Herbal Medicine, 3(2), 10–20, doi: 10.23917/jnhm.v3i2.15658. SaroyoH. ArifahI. A. N. 2021 Antioxidant activity using DPPH & FRAP method and their correlation with the levels of phenolic and flavonoid compounds from nemba plants (Azadirachta indica A. Juss) Journal of Nutraceuticals and Herbal Medicine 3 2 10 20 10.23917/jnhm.v3i2.15658 Open DOISearch in Google Scholar

Saxena, A., Arivaradarajan, P., Mukhopadhyay, A. K., and Nandi, S. P. (2021). Bactericidal effect of neem (Azadirachta indica) leaf extract on Helicobacter pylori. Journal of Environmental Biology, 42(6), 1591–1597, doi: 10.22438/eb/42/6/MRN-2070. SaxenaA. ArivaradarajanP. MukhopadhyayA. K. NandiS. P. 2021 Bactericidal effect of neem (Azadirachta indica) leaf extract on Helicobacter pylori Journal of Environmental Biology 42 6 1591 1597 10.22438/eb/42/6/MRN-2070 Open DOISearch in Google Scholar

Seriana, I., Akmal, M., Darusman, Wahyuni, S., Khairan, K., and Sugito. (2021). Phytochemicals characterizations of neem (Azadirachta indica A. Juss) leaves ethanolic extract: An important medicinal plant as male contraceptive candidate. Rasayan Journal of Chemistry, 14(1), 343–350, doi: 10.31788/RJC.2021.1415899. SerianaI. AkmalM. Darusman WahyuniS. KhairanK. Sugito 2021 Phytochemicals characterizations of neem (Azadirachta indica A. Juss) leaves ethanolic extract: An important medicinal plant as male contraceptive candidate Rasayan Journal of Chemistry 14 1 343 350 10.31788/RJC.2021.1415899 Open DOISearch in Google Scholar

Shahidi, F., and Zhong, Y. (2015). Measurement of antioxidant activity. Journal of Functional Foods, 18, 757–781, doi: 10.1016/j.jff.2015.01.047. ShahidiF. ZhongY. 2015 Measurement of antioxidant activity Journal of Functional Foods 18 757 781 10.1016/j.jff.2015.01.047 Open DOISearch in Google Scholar

Sharma, K., Ko, E. Y., Assefa, A. D., Ha, S., Nile, S. H., Lee, E. T., and Park, S. W. (2015). Temperature-dependent studies on the total phenolics, flavonoids, antioxidant activities, and sugar content in six onion varieties. Journal of Food and Drug Analysis, 23(2), 243–252, doi: 10.1016/j.jfda.2014.10.005. SharmaK. KoE. Y. AssefaA. D. HaS. NileS. H. LeeE. T. ParkS. W. 2015 Temperature-dependent studies on the total phenolics, flavonoids, antioxidant activities, and sugar content in six onion varieties Journal of Food and Drug Analysis 23 2 243 252 10.1016/j.jfda.2014.10.005 935177028911379Open DOISearch in Google Scholar

Shehata, M. G., Abd El Aziz, N. M., Youssef, M. M., and El-Sohaimy, S. A. (2021). Optimization conditions of ultrasound-assisted extraction of phenolic compounds from orange peels using response surface methodology. Journal of Food Processing and Preservation, 45(10), e15870, doi: 10.1111/jfpp.15870. ShehataM. G. Abd El AzizN. M. YoussefM. M. El-SohaimyS. A. 2021 Optimization conditions of ultrasound-assisted extraction of phenolic compounds from orange peels using response surface methodology Journal of Food Processing and Preservation 45 10 e15870 10.1111/jfpp.15870 Open DOISearch in Google Scholar

Shehata, E., Grigorakis, S., Loupassaki, S., and Makris, D. P. (2015). Extraction optimisation using water/glycerol for the efficient recovery of polyphenolic antioxidants from two Artemisia species. Separation and Purification Technology, 149, 462–469, doi: 10.1016/j.seppur.2015.06.017. ShehataE. GrigorakisS. LoupassakiS. MakrisD. P. 2015 Extraction optimisation using water/glycerol for the efficient recovery of polyphenolic antioxidants from two Artemisia species Separation and Purification Technology 149 462 469 10.1016/j.seppur.2015.06.017 Open DOISearch in Google Scholar

Shewale, S., and Rathod, V. K. (2018). Extraction of total phenolic content from Azadirachta indica or (neem) leaves: Kinetics study. Preparative Biochemistry and Biotechnology, 48(4), 312–320, doi: 10.1080/10826068.2018.1431784. ShewaleS. RathodV. K. 2018 Extraction of total phenolic content from Azadirachta indica or (neem) leaves: Kinetics study Preparative Biochemistry and Biotechnology 48 4 312 320 10.1080/10826068.2018.1431784 29424626Open DOISearch in Google Scholar

Singh, P., Chamoli, P., Sachdev, S., Raina, K. K., and Shukla, R. K. (2020). Structural, optical and rheological behavior investigations of graphene oxide/glycerol based lyotropic liquid crystalline phases. Applied Surface Science, 509, 144710, doi: 10.1016/j.apsusc.2019.144710. SinghP. ChamoliP. SachdevS. RainaK. K. ShuklaR. K. 2020 Structural, optical and rheological behavior investigations of graphene oxide/glycerol based lyotropic liquid crystalline phases Applied Surface Science 509 144710 10.1016/j.apsusc.2019.144710 Open DOISearch in Google Scholar

Siroha, A. K., Sandhu, K. S., and Kaur, M. (2016). Physicochemical, functional and antioxidant properties of flour from pearl millet varieties grown in India. Journal of Food Measurement and Characterization, 10(2), 311–318, doi: 10.1007/s11694-016-9308-1. SirohaA. K. SandhuK. S. KaurM. 2016 Physicochemical, functional and antioxidant properties of flour from pearl millet varieties grown in India Journal of Food Measurement and Characterization 10 2 311 318 10.1007/s11694-016-9308-1 Open DOISearch in Google Scholar

Subapriya, R., and Nagini, S. (2005). Medicinal properties of neem leaves: A review. Current Medicinal Chemistry - Anti-Cancer Agents, 5(2), 149–156, doi: 10.2174/1568011053174828. SubapriyaR. NaginiS. 2005 Medicinal properties of neem leaves: A review Current Medicinal Chemistry - Anti-Cancer Agents 5 2 149 156 10.2174/1568011053174828 15777222Open DOISearch in Google Scholar

Sunarwidhi, A. L., Sudarsono, S., and Nugroho, A. E. (2014). Hypoglycemic effect of combination of Azadirachta indica A. Juss. and Gynura procumbens (Lour.) Merr. ethanolic extracts standardized by rutin and quercetin in alloxan-induced hyperglycemic rats. Advanced Pharmaceutical Bulletin, 4(Suppl 2), 613–618, doi: 10.5681/apb.2014.090. SunarwidhiA. L. SudarsonoS. NugrohoA. E. 2014 Hypoglycemic effect of combination of Azadirachta indica A. Juss. and Gynura procumbens (Lour.) Merr. ethanolic extracts standardized by rutin and quercetin in alloxan-induced hyperglycemic rats Advanced Pharmaceutical Bulletin 4 Suppl 2 613 618 10.5681/apb.2014.090 431241325671197Open DOISearch in Google Scholar

Tatke, P., Desai, S., and Gabhe, S. Y. (2014). Isolation of quercetin-3-O-β-D-glucoside from Azadirachta indica. American Journal of Phytomedicine and Clinical Therapeutics, 2(7), 870–876. TatkeP. DesaiS. GabheS. Y. 2014 Isolation of quercetin-3-O-β-D-glucoside from Azadirachta indica American Journal of Phytomedicine and Clinical Therapeutics 2 7 870 876 Search in Google Scholar

Tungmunnithum, D., Thongboonyou, A., Pholboon, A., and Yangsabai, A. (2018). Flavonoids and other phenolic compounds from medicinal plants for pharmaceutical and medical aspects: An overview. Medicines, 5(3), 93, doi: 10.3390/medicines5030093. TungmunnithumD. ThongboonyouA. PholboonA. YangsabaiA. 2018 Flavonoids and other phenolic compounds from medicinal plants for pharmaceutical and medical aspects: An overview Medicines 5 3 93 10.3390/medicines5030093 616511830149600Open DOISearch in Google Scholar

Wolfson, A., Dlugy, C., and Shotland, Y. (2007). Glycerol as a green solvent for high product yields and selectivities. Environmental Chemistry Letters, 5(2), 67–71, doi: 10.1007/s10311-006-0080-z. WolfsonA. DlugyC. ShotlandY. 2007 Glycerol as a green solvent for high product yields and selectivities Environmental Chemistry Letters 5 2 67 71 10.1007/s10311-006-0080-z Open DOISearch in Google Scholar

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