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Forum of Clinical Oncology
Volume 13 (2022): Issue 3 (December 2022)
Open Access
Hydroxyurea ulcers of unusual location: a case report and review of literature
Mansilla-Polo Miguel
Mansilla-Polo Miguel
,
Navarro-Mira Miguel Ángel
Navarro-Mira Miguel Ángel
and
Botella-Estrada Rafael
Botella-Estrada Rafael
| Nov 13, 2023
Forum of Clinical Oncology
Volume 13 (2022): Issue 3 (December 2022)
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Article Category:
Research Article
Published Online:
Nov 13, 2023
Page range:
62 - 65
Received:
Mar 22, 2023
Accepted:
Aug 17, 2023
DOI:
https://doi.org/10.2478/fco-2023-0008
Keywords
Hydroxyurea
,
Ulcers
,
Side effects
,
Hematology
© 2023 Mansilla-Polo Miguel et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Figure 1:
Lesions before discontinuation of hydroxyurea. (a and b) Numerous ulcers with well-defined borders located on the dorsum of the fingers can be seen. Also, appreciate the reddish hue on the back of the interphalangeal and metacarpophalangeal joints, creating a “pseudo-Gottron” pattern, like dermatomyositis. Nail brittleness and melanonychia are seen, features that are also widely described in urea toxicity. In (c), a dermatoscopic detail of the lesions can be seen, showing ulcers with very well-defined borders, with a whitish halo surrounded by another more erythematous one on the outside. The appearance of the ulcer is crusty and dry. (d) Shows detail of involvement in the palmar aspect.
Figure 2:
Lesions after discontinuation of hydroxyurea. One month after discontinuation of therapy, the patient showed a notable improvement in the lesions (a), in the case of smaller and clinically asymptomatic ulcers. In (b), improvement is also seen at the palmar level.