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Hydroxyurea ulcers of unusual location: a case report and review of literature

Mansilla-Polo Miguel

Mansilla-Polo Miguel

  • Dermatology Service, Hospital Universitario y Politécnico La FeValencia, Spain
  • Health Research Institute Hospital La Fe (IIS La Fe)
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Miguel, Mansilla-Polo
, 
Navarro-Mira Miguel Ángel

Navarro-Mira Miguel Ángel

  • Dermatology Service, Hospital Universitario y Politécnico La FeValencia, Spain
  • Health Research Institute Hospital La Fe (IIS La Fe)
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Miguel Ángel, Navarro-Mira
 et 
Botella-Estrada Rafael

Botella-Estrada Rafael

  • Dermatology Service, Hospital Universitario y Politécnico La FeValencia, Spain
  • Health Research Institute Hospital La Fe (IIS La Fe)
  • Faculty of Medicine, University of ValenciaValencia, Spain
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Rafael, Botella-Estrada
  
13 nov. 2023
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Catégorie d'article: Research Article
Publié en ligne: 13 nov. 2023
Pages: 62 - 65
Reçu: 22 mars 2023
Accepté: 17 août 2023
DOI: https://doi.org/10.2478/fco-2023-0008
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© 2023 Mansilla-Polo Miguel et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1:

Lesions before discontinuation of hydroxyurea. (a and b) Numerous ulcers with well-defined borders located on the dorsum of the fingers can be seen. Also, appreciate the reddish hue on the back of the interphalangeal and metacarpophalangeal joints, creating a “pseudo-Gottron” pattern, like dermatomyositis. Nail brittleness and melanonychia are seen, features that are also widely described in urea toxicity. In (c), a dermatoscopic detail of the lesions can be seen, showing ulcers with very well-defined borders, with a whitish halo surrounded by another more erythematous one on the outside. The appearance of the ulcer is crusty and dry. (d) Shows detail of involvement in the palmar aspect.
Lesions before discontinuation of hydroxyurea. (a and b) Numerous ulcers with well-defined borders located on the dorsum of the fingers can be seen. Also, appreciate the reddish hue on the back of the interphalangeal and metacarpophalangeal joints, creating a “pseudo-Gottron” pattern, like dermatomyositis. Nail brittleness and melanonychia are seen, features that are also widely described in urea toxicity. In (c), a dermatoscopic detail of the lesions can be seen, showing ulcers with very well-defined borders, with a whitish halo surrounded by another more erythematous one on the outside. The appearance of the ulcer is crusty and dry. (d) Shows detail of involvement in the palmar aspect.

Figure 2:

Lesions after discontinuation of hydroxyurea. One month after discontinuation of therapy, the patient showed a notable improvement in the lesions (a), in the case of smaller and clinically asymptomatic ulcers. In (b), improvement is also seen at the palmar level.
Lesions after discontinuation of hydroxyurea. One month after discontinuation of therapy, the patient showed a notable improvement in the lesions (a), in the case of smaller and clinically asymptomatic ulcers. In (b), improvement is also seen at the palmar level.
Langue:
Anglais
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2 fois par an
Sujets de la revue:
Médecine, Médecine clinique, Médecine interne, Hématologie, oncologie
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