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Assessing the potential role of neutrophil elastase as a prognostic indicator in oral squamous cell carcinoma

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Pratiksha Mahajan

Mahajan, Pratiksha

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A. Thirumal Raj

Thirumal Raj, A.

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and

Apr 05, 2020

Assessing the potential role of neutrophil elastase as a prognostic indicator in oral squamous cell carcinoma's Cover Image

Forum of Clinical Oncology

Volume 10 (2019): Issue 2 (December 2019)

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Article Category: Research Article

Published Online: Apr 05, 2020

Page range: 34 - 38

Received: Sep 10, 2018

Accepted: Mar 25, 2019

DOI: https://doi.org/10.2478/fco-2019-0004

Keywords
Leukocyte elastase, lymphatic metastasis, staining and labelling, carcinoma, squamous cell

© 2019 Pooja Jaiswal et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

NE immunostaining in OSCC. A- No NE immuno-staining (400 × magnification), B- Mild (1–25%) NE immuno-staining (400 × magnification), C- Intense (>50%) NE immuno-staining (400 × magnification).

Study characteristics_

Study groups	Average Age (in years)	Gender		Site				Staging

		Male	Female	Gingivo-buccal sulcus	Alveolus	Tongue	Buccal mucosa	III	IV
OSCC with lymph node metastasis	52.92	16	9	8	10	3	4	18	7
OSCC without lymph node metastasis	53.88	17	8	9	11	2	3	19	6

Association between staining intensity and lymph node status_

Staining Intensity	Lymph node status			p-value

	N1	N2	N3
Negative	7	0	0	0.001^*
Positive, well differentiated	4	4	3
Positive Moderately Differentiated	0	3	4

Association between staining intensity and lymph node involvement_

Staining Intensity	Lymph node involvement		p-value

	Positive	Negative
Negative	7	20	0.0005^*
+ Positive	12	2
++ Positive	6	3
+++ Positive	0	0

Language:: English

Publication timeframe:: 2 times per year
Journal Subjects:: Medicine, Clinical Medicine, Internal Medicine, Haematology, Oncology

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