<abstract xmlns="http://www.w3.org/1999/xhtml"> Introduction. There is still ongoing discussion about superiority of video-assisted thoracoscopic surgery or VATS approach for performing lobectomy over conventional pulmonary lobectomy performed by open thoracotomy for the treatment of non-small cell lung cancer at an early stage. Aim of the study. This encouraged us to conduct a prospective study for evaluation and comparison of the systemic inflammatory response by using these two approaches. Materials and methods. We have conducted a prospective study for evaluation of C-reactive protein and Fibrinogen as indicators of systemic inflammatory response during early postoperative course. Surgery was prospectively randomised in two groups: 15 patients underwent VATS lobectomy and 15 patients underwent conventional open lobectomy. Blood samples were taken preoperatively, 24 and 72 hours after operation, on the day of drain removal, and 1 and 9 days after the drain removal. Results. Surgery caused systemic inflammatory response in both groups. The increase in CRP was notably higher in OL group in all measurements except preoperative (p&lt;0,05). The increase in Fibrinogen concentrations was also higher in OL group but statistical significance (p&lt;0,05) was reached only in day of drain removal. Conclusions. VATS approach caused reduced systemic inflammatory response compared with conventional open thoracotomy approach and was also associated with lesser postoperative pain as duration of chest drains and total amount of drained effusion is significantly smaller.</abstract>

Introduction. There is still ongoing discussion about superiority of video-assisted thoracoscopic surgery or VATS approach for performing lobectomy over conventional pulmonary lobectomy performed by open thoracotomy for the treatment of non-small cell lung cancer at an early stage. Aim of the study. This encouraged us to conduct a prospective study for evaluation and comparison of the systemic inflammatory response by using these two approaches. Materials and methods. We have conducted a prospective study for evaluation of C-reactive protein and Fibrinogen as indicators of systemic inflammatory response during early postoperative course. Surgery was prospectively randomised in two groups: 15 patients underwent VATS lobectomy and 15 patients underwent conventional open lobectomy. Blood samples were taken preoperatively, 24 and 72 hours after operation, on the day of drain removal, and 1 and 9 days after the drain removal. Results. Surgery caused systemic inflammatory response in both groups. The increase in CRP was notably higher in OL group in all measurements except preoperative (p<0,05). The increase in Fibrinogen concentrations was also higher in OL group but statistical significance (p<0,05) was reached only in day of drain removal. Conclusions. VATS approach caused reduced systemic inflammatory response compared with conventional open thoracotomy approach and was also associated with lesser postoperative pain as duration of chest drains and total amount of drained effusion is significantly smaller.

C-Reactive Protein and Fibrinogen as Indicators of Systemic Inflammatory Response in Patients Undergoing VATS and Conventional Pulmonary Lobectomy

Department of Thoracic Surgery, Centre of Tuberculosis and Lung Diseases, Riga East University Hospital, Upeslejas, Stopinu novads, Latvia LV-2118

Department of Thoracic Surgery, Centre of Tuberculosis and Lung Diseases, Riga East University Hospital, Latvia

Medical Faculty of Latvian University, Latvia

Acta Chirurgica Latviensis

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Introduction. There is still ongoing discussion about superiority of video-assisted thoracoscopic surgery or VATS approach for performing lobectomy over...

C-Reactive Protein and Fibrinogen as Indicators of Systemic Inflammatory Response in Patients Undergoing VATS and Conventional Pulmonary Lobectomy

Published Online: Nov 25, 2014

Page range: 14 - 17

DOI: https://doi.org/10.2478/chilat-2014-0003

© Latvian Surgeons' Association, Latvian Paediatric Surgeon Association, Rīga Stradiņš University

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.